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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"

Báo cáo y học:

Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"

... infavour of Ang-2 is present in critically ill medical patients. Ourfindings highlight the independent prognostic impact ofcirculating Ang-2 in critical illness. Ang-2 may be used as areadily available ... study is a prospective clinical investigation of theprognostic value of circulating Ang-2 as a biomarker in criti-cally ill patients. The results are that: critically ill patients arecharacterised ... thegrowing body of evidence indicating a role for Ang-2 as amediator in critically illness, the value of Ang-2 as a predictivemarker of outcome is poorly defined.The aim of this study was to investigate...
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Báo cáo Y học: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) pdf

Báo cáo Y học: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) pdf

... ectopically expressed cdk3 in association with either cyclin E or cyclin A by transienttransfection (Fig. 2A) . Kinase assays indicated that pRb-phosphorylating activity was prominently upregulated ... and B arised by incomplete tryptic cleavage of the Ser274-containing region. In fact, phosphoamino-acidanalysis of spots A and B indicated that both spots A and Bcontained phosphoserine (Fig. ... same residue is also phosphorylated by bothcdk3/cyclin A and cdk3/E in vivo (Fig. 5). Analysis of ik3-1amino-acid sequence indicates that ik3-1 has a putative ZRXL(Z and X are typically basic)...
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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc

Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc

... mechanism of actionMikhail A. Panteleev, Veronica I. Zarnitsina and Fazoil I. AtaullakhanovNational Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, RussiaWe have analyzed ... result of binding of TFPIto the enzyme–product Xa–VIIa–TF complex and this is themain pathway of inhibition of VIIa–TF during ongoingfactor X activation. Analysis of the present study supportsthis ... coagulation; extrinsic pathway; tissue fac-tor pathway inhibitor; tissue factor; mathematical model.Blood coagulation is initiated upon contact of the integralmembrane glycoprotein tissue factor...
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Báo cáo y học:

Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"

... normal distribution, and such data were analysed statistically. Statistical analysis of the data analysis was carried out using the ANOVA test. Prevalence of alleles and genotype among cases and ... Mukawa H, Tomida T, Suzuki T, Kamiya H, Matsui H, Hayakawa T. Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary ... is an emirates professor in Clinical Pathology at Alexandria University where she has been head of the department in Alexandria Medical Research Institute Teaching hospital till 2001. Her main...
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Tài liệu Báo cáo Y học: Ornithine decarboxylase-antizyme is rapidly degraded through a mechanism that requires functional ubiquitin-dependent proteolytic activity pot

Tài liệu Báo cáo Y học: Ornithine decarboxylase-antizyme is rapidly degraded through a mechanism that requires functional ubiquitin-dependent proteolytic activity pot

... usingethyl acetate/cyclohexane (2 : 3) as a solvent, withdansylated derivatives of known polyamines serving asmarkers. The individual polyamines were visualized byUV illumination.RESULTSAntizyme ... ubiquitin system forits degradation.DISCUSSIONAntizyme is a unique cellular regulatory protein that is bothregulated by polyamines and regulates polyamine metabo-lism in a feedback loop. Antizyme ... S., Matsufuji, T., Miyazaki, Y. , Murakami, Y. , Atkins,J.F., Gesteland, R.F. & Hayashi, S. (1995) Autoregulatory frame-shifting in decoding mammalian ornithine decarboxylase anti-zyme....
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Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt

Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt

... overexpressing the wild-type DAPkinase, t he DCaM-DAP kinase m utant (a c onstitutivelyactive kinase mutant), the K 4 2A- DAP kinase mutant (a catalytically inactive mutant displaying dominant negativefeatures), ... a catalytically inactive DAP kinase mutant and a constructcontaining the death domain and C-terminal tail of DAPkinase, which act in a dominant-n egative manner, rescuedcells from C2-, and ... DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cellsMutsuya Yamamoto, Takeshi Hioki, Takehisa Ishii, Sadayo Nakajima-Iijima and Shigeo Uchino*Pharmaceuticals Discovery...
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Báo cáo Y học: Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides doc

Báo cáo Y học: Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides doc

... extracellu-lar ligand-binding domain, a single transmembrane domain,an intracellular kinase homology domain (KHD) and a catalytic domain (reviewed in [1]). Soluble guanylate cyclases(sGCs) are ... composed of a and b subunits andeach monomer contains a heme binding domain, a dimeri-zation domain, and a catalytic domain [1,6]. The primarystructure of the catalytic domains of sGC and pGC arehomologous, ... inhibition of adenylate and guanylatecyclases is analogous, the two basic residues important forbinding and stabilization of P site inhibitors in the C1–C2interface of the catalytic domain of adenylate...
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Báo cáo y học:

Báo cáo y học: "Spontaneous Hemoperitoneum Caused By a Diverticulum of the Sigmoid Colon"

... bleeding was controlled by #3-0 Vycryl intracorporeal suture, and the invagination of the diverticulum was performed laparoscopically. The recovery was une-ventful, and the patient was discharged ... motility [3]. In most cases, it is asymptomatic, but major complica-tions could include diverticulitis and intraluminal hemorrhage [4, 5]. Interestingly, intraperitoneal hemorrhage of ... to invaginate the diverticulum in- stead of using diverticulectomy. We reported a case of colonic diverticulum that was successfully treated by laparoscopic suture and invagination of...
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Báo cáo y học:

Báo cáo y học: "Primary lower limb lymphedema: a focus on its functional, social and emotional impac"

... proximally extended, leading to impaired daily activity and creating a sensation of heaviness and discomfort. There was no family history of similar disorders. A conventional approach was ... medical history of primary lower limb lymphedema diagnosis by specialists and all accepted to participate in this study when they were asked. Patient’s health status was measured us-ing ... such as infection, trauma or malignancy [1]. The most common cause of secondary lymphedema worldwide is filariasis, an infestation of the lymph nodes by the parasite Wuchereria bancrofti...
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