... metabo-lite syndrome), including carbamazepine, phenytoin,phenobarbital, and lamotrigine. The triad of hypersensi-tivity includes fever, rash and internal organ involvementwith onset of symptoms within ... [57].Recognizing early symptoms of hepatic toxicity and dis-continuing treatment are important in optimizing recov-ery. Early symptoms of hepatic toxicity include apathy,malaise, fever, diminished ... obesity, and that pharmacologictreatment and gender are greater influences [10].Important factors influencing obesity in bipolar patientsinclude nutrient intake and physical activity. In assessingthe...