... by DAS 1.0 (Anhui, China) program. Bioavailability (BA) is a measurement of the rate and extent of a therapeutically active drug that reaches the systemic circulation and is available at the ... vivo evaluation of safety and ecacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials. 30:2329–39. Tsuchihashi, M., Harashima, H., Kiwada, H. (1999). Development of a pharmacokinetic/pharmacodynamic ... where AUC is the area under the curve. Statistical analysis All data are presented as a mean value with its stand- ard deviation indicated (mean ± SD). Statistical analysis was conducted...