... for Tissue Engineering Applications 33 3.1 Introduction As explained in chapter 1, inadequate vascularization is a major bottleneck limiting widespread clinical applications of tissue engineering, ... artificial tissue and organ replacements This is the field of tissue engineering, which has been defined as "an interdisciplinary field that applies the principles of engineering and the life ... regenerating human cells, tissues, and organs and restoring their function, while the term tissue engineering refers to the subset of regenerative medicine approaches that involve the design of tissue...