... signaling pathway (b) Quantification of the effects of different siRNAs targeting the PtdIns(3,4,5)P3-mTOR pathway and rapamycin (RAPA) on transferrin uptake Means ± standard error of the mean ... uptake is under the control of the PtdIns(3,4,5)P3-mTOR signaling pathway Identification of the mTOR pathway as primary signaling module controlling transferrin uptake The PI3K-mTOR pathway controls ... of the players, as well as of the direction of the effects, a signature of a particular signaling pathway In addition to signature proteins of the PtdIns(3,4,5)P3-mTOR pathway, the other hits...