... compilation ª 2010 FEBS 1819 H3K4 methyltransferases from yeast to human 136 137 138 139 140 141 142 143 144 145 146 147 S Malik and S R Bhaumik histone H3- lysine 4- specific methyltransferase Mol ... of HoxA9 [ 145 , 147 ] Further, the MLL3 ⁄ MLL4 complex coordinates H3K4 methylation with demethylation of histone H3 at K27 through its UTX subunit [49 ,133,1 34, 148 , 149 ] Furthermore, H3K4 methylation ... methylation of histones H3 and H4 with crucial roles in maintaining normal cellular functions in eukaryotes ranging from yeast to humans (Fig 1) Here, we discuss histone H3 lysine (H3K4) methylation...