... his innovationhowever. Decades passed, and as statistical concepts began to seep into medical conscious-ness,itseemsthatthenotionofrandomizationalsobegantocomeintobeing .In 1905, in the main insane ... the rst in psychiatry involving lithium in 195 2and the antipsychotic chlorpromazine in 1954. is is the standard history, and it is cor-rectinthesensethatFisherandHillwereclearlythersttoformallydeveloptheconceptSection ... double-blinding is the usual means of handling measurement bias.Randomization is the best means of addressing confounding bias, and blinding the meansfor measurement bias. While blinding is important,...