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FIRST TOTAL SYNTHESIS OF 11 TELLURA STEROIDS

Tandem isomerization reaction of alkyne  total synthesis of alpha yohimbine

Tandem isomerization reaction of alkyne total synthesis of alpha yohimbine

... TANDEM ISOMERIZATION REACTION OF ALKYNES: TOTAL SYNTHESIS OF ALPHA- YOHIMBINE FENGWEI 2012 TANDEM ISOMERIZATION REACTIONS OF ALKYNES: TOTAL SYNTHESIS OF ALPHA- YOHIMBINE FENG WEI ... Enantioselective isomerization of alkynes to allenes Scheme 3.1.1 Total synthesis of alpha- yohimbine, route1 Scheme 3.1.2 Total synthesis of alpha- yohimbine, route Scheme 3.1.3 Total synthesis of alpha- yohimbine, ... - 45 Chapter Total synthesis of alpha- yohimbine via intramolecular-Diels-Alder reaction 3.1 Introduction to the synthesis of alpha- yohimbine 48 3.2 Tandem- isomerization intramolecular-Diels-Alder...
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Total synthesis of the potent antibiotic platensimycin

Total synthesis of the potent antibiotic platensimycin

... high-yielding synthesis of the aromatic unit (1-151) of 284 platensimycin Scheme 5.9 Preparation of the C6-methoxy analog (5-60) of (-)- 286 platensimycin Scheme 5.10 Completion of the total synthesis of ... between the benzoic acid and the four critical amino acid residues 1.4 Biosynthesis of Platensimycin By understanding the biosynthetic pathways leading to the biosynthesis of platensimycin, the Merck ... TOTAL SYNTHESIS OF THE POTENT ANTIBIOTIC PLATENSIMYCIN EEY TZE CHIANG STANLEY (B.Sc.(Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMISTRY...
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Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 1 4

Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 1 4

... δ 15 9 .42 , 15 8 .10 , 15 5.06, 15 5.03, 15 4 .19 , 15 3.80, 15 3.25, 15 1.98, 12 9.50, 12 9.03, 12 8.39, 12 8 .12 , 12 4. 42, 12 3.22, 12 2.83, 12 1. 34, 12 1.29, 12 0.66, 11 1 .49 , 11 1.23, 11 1. 01, 11 0.55, 10 6 .10 , 10 4. 92, ... 16 1.5, 16 1 .4, 16 1.3, 15 9.8, 15 9.7, 15 9.7, 15 9.6, 15 8.7, 15 8.2, 15 7.3, 15 3.7, 14 4. 7, 12 3.9, 12 3.9, 12 3.6, 12 3.3, 12 1.2, 12 0.8, 12 0.7, 11 9.5, 11 7 .4, 11 7.2, 11 7.2, 11 5.9, 10 6.0, 10 5.6, 10 4. 4, 10 0 .4, 10 0 .1, ... 15 0.66, 13 0.96, 12 8.29, 12 7 .16 , 12 5. 54, 12 2.82, 12 2.68, 12 2.03, 12 1.57, 12 1 .11 , 11 8.32, 11 1.66, 11 1.39, 11 0.90, 11 0 . 14 , 10 9.55, 10 6. 74, 10 4. 95, 10 3.72, 52. 64, 47 .66, 34. 66, 29.93, 11 .77, 11 .76;...
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Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 5

Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 5

... O OTs 5- 10 C43H36O9S2 760.9 OBn OTs O FT-IR Data 3 25 O OH OBn 5- 11 C29H24O5 452 .5 OH O 326 Appendix O O O OBn 5- 12 C29H24O5 452 .5 O FT-IR Data 327 O O O 5- 13 C44H32O8 688.7 O O O O O 328 Appendix ... Data 337 HO O 5- 28 C14H16O3 232.3 O 338 Appendix HO O 5- 33 C14H16O3 232.3 OH FT-IR Data 339 AcO O O 5- 32 C16H18O4 274.3 340 Appendix AcO O OAc 5- 35 C18H20O5 316.3 FT-IR Data 341 AcO O 5- 38 C18H20O6 ... 3 -56 C30H34O7S2Si 59 8.8 O TES FT-IR Data 333 HO OH 3 -57 C16H22O3Si 290.4 O TES 334 Appendix HO O 3- 35 C16H22O3Si 290.4 O TES FT-IR Data 3 35 HO O 3-34 C10H7IO3 302.1 O I 336 Appendix FT-IR Data...
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Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 6

Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 6

... Low-Resolution-Mass Data HO O 5-33 C14H16O3 232.3 OH 373 AcO O O 5-32 C16H18O4 274.3 374 Appendix Low-Resolution-Mass Data AcO O OAc 5-35 C18H20O5 3 16. 3 375 AcO O 5-38 C18H20O6 332.3 OAc O 3 76 Appendix ... Low-Resolution-Mass Data 353 OH O 5-2 C18H14O3 278.3 O 354 Appendix Low-Resolution-Mass Data 355 O 5-4 C36H24O4 520 .6 O O O O O 5 -6 C36H24O4 520 .6 O O 3 56 Appendix Low-Resolution-Mass Data I OH 5-8 ... Low-Resolution-Mass Data 361 O O O 5-13 C44H32O8 68 8.7 O O O O O 362 Appendix Low-Resolution-Mass Data OTs 5-18 C20H17IO6S2 544.4 TsO I 363 TsO OTs OBn 5-19 C53H44O13S4 1017.2 OTs OTs 364 Appendix Low-Resolution-Mass...
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Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 7

Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 7

... 232.1099 412 Appendix O AcO O 5-32 C16H18O4 274 .1205 High-Resolution-Mass Data 413 O AcO OAc 5-35 C18H20O5 316.1311 414 Appendix O O AcO OAc 5-38 C18H20O6 332.1260 High-Resolution-Mass Data 415 O ... High-Resolution-Mass Data 391 O O O O 5-4 C36H24O4 520.1 675 392 Appendix O O O O 5-6 C36H24O4 520.1 675 High-Resolution-Mass Data 393 O I OH 5-8 C8H7IO2 261.9491 394 Appendix O I OTs 5-9 C15H13IO4S 415.9 579 ... 380 Appendix O HO I OH 3-11 C8H7IO3 277 .9440 High-Resolution-Mass Data 381 O TsO I OTs 3-2 C22H19IO7S2 585.96 17 382 Appendix OBn 3-3 C13H12O 184.0888 TsO O OTs 3-24 C57H48O15S4 1100.1 876 OBn...
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Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 8

Affinity guided isolation, structure elucidation and total synthesis of laetirobin a and its analogue synthesis for therapeutic development 8

... Programme (PhD student under the supervision of Dr Martin Lear) • Affinity- Guided Isolation, Structure Elucidation and Total Synthesis of Laetirobin A and Its Analogue Synthesis for Therapeutic Development ... theta = 27. 48 99 .8 % Absorption correction Sadabs, (Sheldrick 2001) Max and transmission 0. 988 8 and 0.9456 Refinement method Full-matrix least-squares on F2 Data / restraints / parameters 24 58 ... cooperation with the Roche Diagnostics Department of Rare Reagents Hoechst AG, Frankfurt, Germany 1992 - 1995 Today part of the Sanofi-Aventis group Chemical Technician Apprenticeship and Qualification...
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Stereochemical assignment and total synthesis of an antimalarial lipopeptide

Stereochemical assignment and total synthesis of an antimalarial lipopeptide

... STEREOCHEMICAL ASSIGNMENT AND TOTAL SYNTHESIS OF AN ANTIMALARIAL LIPOPEPTIDE SHIBAJI KUMAR GHOSH (M.Sc, UNIVERSITY OF CALCUTTA) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... Ghosh, Martin J Lear; Stereochemical Assignment and Total Synthesis of an Anti-malarial Lipopeptide , The 6th Mathematics and Physical Science Graduate Congress, University of Malaya, Malaysia ... Ghosh, Brinda Somanadhan, Mark S Butler, Martin J Lear; “Amino Acid Stereochemical Assignment and Total Synthesis of A Natural Anti-malarial Peptide”, 239th ACS National Meeting, San Francisco, CA,...
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Synthetic studies towards total synthesis of bielschowskysin 1

Synthetic studies towards total synthesis of bielschowskysin 1

... lophotoxin and 11 pukalide   x   Scheme 1. 9 Marshall’s synthesis of the furan moiety of rubifolide 11 Scheme 1. 10 Marshall’s synthesis of furan moiety from an alkynone β-ketoester 11 Scheme 1. 11 Paquette’s ... Characterisation 1. 1.2 Biological Activity 1. 1.2 .1 Antimalarial Agents and Continuing Needs 1. 1.3 Proposed Biosynthesis 1. 1.4 Related Diterpene Natural Products 1. 1.5 Relevant Synthetic Efforts 1. 1.5 .1 Butenolide ...   iv   1. 1.5.2 Furan Construction 10 1. 1.5.3 Macrocycle Construction 12 1. 1.6 Sulikowski’s Synthetic Study 14 1. 2 Approaches toward Related Diterpenes 1. 2 .1 Leo Paquette Approach 15 1. 2.2 Marshall...
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Synthetic studies towards total synthesis of bielschowskysin 2

Synthetic studies towards total synthesis of bielschowskysin 2

... natural products, we have begun studies towards the total synthesis of Our approach is to mimic the biosynthesis of by the [2+ 2] photo-cycloaddition of allenyl -2( 5H)furanone 157 under high stereocontrol ... stereocontrol to form the tricyclic core27 (Figure 2. 1) Figure 2. 1: Proposed model study of the tricyclic core of bielschowskysin 2. 2 Model Study: [2+ 2] Cycloaddition of Allene-Butenolide As an intramolecular ... Et2O BuOOH 93 O 94 H2 C 1-bromo -2- butyne C CH 95 (COCl) 2, DMSO CH Cl2 , Et3 N, -78 °C HO DIBAL-H O AgNO3 , acetone SnCl2 , NaI, DMPU H 3CO2 C H 3CO2 C 96 97 CBr , PPh3 OHC O Et 3N, CH 2Cl2 O...
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Part 1 total synthesis and biological evaluation of antillatoxin and fragments part II synthetic studies towards the total synthesis of cytochalasans and tuberostemonine

Part 1 total synthesis and biological evaluation of antillatoxin and fragments part II synthetic studies towards the total synthesis of cytochalasans and tuberostemonine

... PART I TOTAL SYNTHESIS AND BIOLOGICAL EVALUATION OF ANTILLATOXIN AND FRAGMENTS PART II SYNTHETIC STUDIES TOWARDS THE TOTAL SYNTHESIS OF CYTOCHALASANS AND TUBEROSTEMONINE APPENDIX ... Biological Evaluation of Antillatoxin and Fragments 1. 1 Historical Background 1. 2 Previous Synthetic Studies 1. 3 Our Retrosynthetic Analysis of Antillatoxin 11 1. 4 Results and Discussion 15 1. 5 ... 1. 5 Biological Evaluation of Antillatoxin and Fragments Using Zebrafish Embryo 30 1. 6 Conclusion 44 1. 7 Experimental 45 Part II Chapter 2: Synthetic Studies Towards the Total Synthesis of Cytochalasans...
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The total synthesis of c1 azacycloalkyl hexahyroccannabinoids  the total synthesis of 3 oxaadamantyl hexahydrocannabinoids  the synthesis of bicyclic 3 adamantyl cannabinoids

The total synthesis of c1 azacycloalkyl hexahyroccannabinoids the total synthesis of 3 oxaadamantyl hexahydrocannabinoids the synthesis of bicyclic 3 adamantyl cannabinoids

... 63 Chapter THE TOTAL SYNTHESIS OF 3- OXAADAMANTYL 9-HYDROXY HEXAHYDROCANNABINOIDS 98 3. 1 Introduction 99 3. 2 Total Synthesis of 3- Oxaadamantyl 9-Hydroxy Hexahydrocannabinoids ... group of Professor Makriyannis Chapter The synthesis of two series of cannabinoids: the bicyclic 3- adamantyl cannabinoids and the 3' -functionalized 3- oxaadamantyl 9-hydroxymethyl hexahydrocannabinoids ... 9-HYDROXYMETHYL HEXAHYDROCANNABINOIDS 134 4.1 Synthesis of Bicyclic 3- Adamantyl Cannabinoids 135 4.2 Synthesis of 3- Oxaadamantyl 9-Hydroxymethyl Hexahydrocannabinoids 142 4 .3 Receptor Binding...
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báo cáo khoa học:

báo cáo khoa học: "Note Selection for increased and decreased total number of young born in the first three parities in mice" doc

... Two of these divergently selected for large (L and small (L-) reproduction rate, the selection ) + criterion being the total number of young born alive in the first three parities (TNY-3) The third ... reduced following selection for first litter size a Selection for increased TNY-3 resulted in a moderate response in 1st litter size to the C and L- lines was maintained for the 2nd and 3rd litter ... selected for first litter size showed AKKER decrease in the size of the 2nd, 3rd and following litters below the control line That result was attributed to an effect of overloading in the uterus...
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