... 2 Colby College Molecular Mechanics Tutorial Introduction September 2008 Thomas W Shattuck Department of Chemistry Colby College Waterville, Maine 04901 Please, ... maintain storerooms filled with hundreds of thousands of compounds and develop combinatorial libraries (groups of compounds) of hundreds of thousands more It is often necessary to store and retrieve ... example, the Gibb's Free Energy of solution of hydrophobic molecules1, of binding of crown ethers to polar organics2, and the binding of NADP and NADPH to dihydrofolate reductase3 have been studied...