... extended conformation Remarkably, ibuprofen, a nonsteroidal anti-inflammatory agent [12], and warfarin, an anticoagulant drug [12], are considered as stereotypical ligands for Sudlow’s site II and Sudlow’s ... HSA inhibits ibuprofen and warfarin association to the warfarin primary cleft (i.e Sudlow’s site I), corresponding to the ibuprofen secondary site [1,3,11] Then, ibuprofen and warfarin impair ... may reflect a conformational transition(s) towards a ferric HSA –haem state where slowly exchanging water molecules are far apart from the paramagnetic centre On the other hand, the lifetime of...