Inhaled nitric oxide for treatment persistent pulmonary hypertension in the newborn

Inhaled nitric oxide for treatment persistent pulmonary hypertension in the newborn

Inhaled nitric oxide for treatment persistent pulmonary hypertension in the newborn
... multicenter study The INO/PPHN Study Group Pediatrics 1998;101(3 Pt 1):325 Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn Clinical Inhaled Nitric Oxide Research ... Barefield ES, Kattwinkel J, Dudell G, Damask M, Straube R, Rhines J, Chang CT Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, ... of the pulmonary vasculature : underdevelopment, maldevelopment, and maladaptation 1.9/ 1000 live births NITRIC OXIDE Does Inhaled NO effect in PPHN ? Nitric oxide for respiratory failure in infants...
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Báo cáo y học: "Inhaled nitric oxide in persistent pulmonary hypertension of the newborn refractory to high-frequency ventilatio" ppsx

Báo cáo y học:
... phosphodiesterase inhibitor (dipyridamole) [16] Study of the mechanism of INO dependency may give insight into new therapies that augment the pulmonary vasodilatory effect of INO and the activity of the endogenous ... of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn Pediatrics 1996, 98:706–713 12 The Neonatal Inhaled Nitric Oxide Study (NINOS) Group: Inhaled nitric oxide ... trial of inhaled nitric oxide and high-frequency ventilation in severe persistent pulmonary hypertension of the newborn Pediatr Res 1996, 139:252A The NINOS Study Group: Inhaled nitric oxide...
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Báo cáo y học: "Hyaluronan modulates accumulation of hypoxiainducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model" potx

Báo cáo y học:
... Hyaluronan modulates accumulation of hypoxia -inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model Arthritis ... mirrors much of the pathology of RA, including hyperplasia of the synovial tissues, inflammatory infiltration of the joints, and destruction of bone and cartilage in the synovial joint [23] The present ... infiltration in the synovium and accumulation of HIF-1a, iNOS, and MMP3 were suppressed after intra-articular administration of HA at the early phase of adjuvant-induced inflammation The extent of...
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Báo cáo y học: "Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary result" ppt

Báo cáo y học:
... compliance and airway resistance, and the response of these parameters to inhaled NO Our preliminary results demonstrated that cell-free hemoglobin-induced pulmonary hypertension and decreased lung ... selectively reverses pulmonary hypertension and decreased lung compliance induced by cell-free hemoglobin blood substitutes Acknowledgements The authors thank Tatsuo Uchida for statistical analysis and ... can selectively reverse the pulmonary hypertension and decreased lung compliance induced by cell-free hemoglobin This suggests that its is possible to effectively control potentially deleterious...
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Báo cáo y học: " Equipment review: Pulmonary uptake and modes of administration of inhaled nitric oxide in mechanically-ventilated patients" ppt

Báo cáo y học:
... into the inspiratory limb; iy = sequential administration into the Y- piece; ci = continuous administration into the inspiratory limb; cy = continuous administration into the Y piece Published ... pulmonary diffusing capacity with nitric oxide and carbon monoxide Eur Respir J 1989, 2:56-63 doi:10.1186/cc118 Cite this article as: Puybasset and Rouby: Equipment review: Pulmonary uptake and modes ... inspiratory NO concentration As shown in Fig 7, any change in the patient’s inspiratory drive resulting in variations in tidal volume, inspiratory flow and duration induced fluctuation in inspiratory...
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Báo cáo y học: " Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?" doc

Báo cáo y học:
... oxygenation, but it may also provide potent anti-inflammatory effects [23] Here we report a case of severe traumatic brain injury with dramatically elevated intracranial pressure in the setting of ... efforts at combating inflammation The use of INO in this report was for emergent and compassionate use in the setting of critically elevated intracranial pressure accompanied by ARDS, hypoxemia, ... inspiratory and plateau pressures, and oxygenation, in an effort to increase the PaO2 to an acceptable level (a goal of PaO2 100 mm Hg) In view of the fact that maximized ventilator settings, adequate...
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Báo cáo khoa học: A pathway through interferon-c is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells pot

Báo cáo khoa học: A pathway through interferon-c is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells pot
... morphological criteria The murine macrophage cell line RAW264.7, originally from the American Type Culture Collection (Manassas, VA, USA) and maintained in our laboratory, was also used For cell ... antibody pairs A 96-well EIA/RIA plate (Corning Inc.), coated with a coating antibody and masked with skim milk, was incubated with test samples and standard solutions A biotin-labeled detecting antibody ... production in murine macrophage cell line culture, but a minor pathway in peritoneal cell culture The indirect pathway, through IFN-c, was indicated to play the major role in the peritoneal cell...
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Báo cáo y học: "Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study" ppt

Báo cáo y học:
... Comparative changes in (a) mean pulmonary artery pressure (∆MPAP) and (b) pulmonary vascular resistance index (∆PVRI) induced by increasing inspiratory intratracheal concentrations of inhaled ... hemodynamic and respiratory paramaters were measured at the same ventilator settings as in phase Statistical analysis Cardiorespiratory parameters at control were compared between groups using a ... hemodynamic and respiratory parameters in the presence or absence of septic shock were analysed using a two-way analysis of variance for one within and one grouping factor, ie factor `group (absence...
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Báo cáo y học: "Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis" pps

Báo cáo y học:
... neuronal serotonin (5-HT) reuptake, but also trigger indoleamine release has sparked renewed interest for the serotonin hypothesis’ of PH In our laboratory, we recently tested the hypothesis that the ... encoded by a single gene [14] These facts initially led to the hypothesis that fenfluramine-like medications may elevate circulating 5-HT levels [15,16], which in turn may increase pulmonary artery ... possibility that fenfluramine and other anorexigens might increase the risk of primary PH by interacting directly with 5-HTT Interestingly, drugs known or suspected to increase the risk of primary PH...
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Báo cáo y học: "What is the role of surfactant and inhaled nitric oxide in lung transplantation" pps

Báo cáo y học:
... solution the hypothesis that this combination prevents intrapulmonary shunt more effectively than does either intervention alone, and that it reduces inactivation of surfactant substitutes In summary, ... death and infection of the donor lung, reduced surfactant function is aggravated by preservation of the graft, ischaemia and reperfusion Therefore, substitution of surfactant may bridge the patient ... justification is there for the use of these approaches in lung transplantation? A body of evidence has been established that indicates that surfactant function after lung transplantation is reduced in all...
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Báo cáo y học: "Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease" ppt

Báo cáo y học:
... behind this study was based on the findings that angiotensin converting enzyme and angiotensin II are both involved in the pulmonary vascular remodelling associated with hypoxic pulmonary hypertension ... 23(89):57-72 Yu PN, Lovejoy FW Jr, Joos HA, Nye RE Jr, McCann WS: Studies of pulmonary hypertension I Pulmonary circulatory dynamics in patients with pulmonary emphysema at rest J Clin Invest 1953, ... variable findings have been reported [14-17,34,35] The only reported study using losartan in pulmonary hypertension secondary to COPD was also in the acute setting [14] Oral dosing with losartan...
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Báo cáo khoa học: "Inhaled nitric oxide: another weapon in our armamentarium in the battle against acute hypoxic respiratory failure in preterm infants" pptx

Báo cáo khoa học:
... the present study suggests that iNO may influence clinical outcomes as well This should be a consideration in our armamentarium in the battle against AHRF The recognition that AHRF is often the ... [2] Acute hypoxic respiratory failure (AHRF) encompasses acute respiratory distress syndrome and acute lung injury and remains a significant cause of death in the intensive care unit With the ... of bleeding time have been demonstrated in neonates [14,15] In the present study there was no evidence of increased intraventricular hemorrhage in the iNO group The mechanism by which NO inhibits...
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Báo cáo y học: "Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury" docx

Báo cáo y học:
... 0.05 between baseline and before INO Endotoxin also caused a rapid release of inflammatory mediators and vasoactive substances Prostanoids, LTB4, ET-1, nitrates and cytokines increased in the ... levels of the proinflammatory cytokine IL-8 followed the endotoxin evolution in blood Endothelin-1 and inhaled nitric oxide The ET-1 in plasma rose rapidly and markedly already after hour and paralleled ... compare physiological and biochemical events to try to elucidate the mechanisms of response and nonresponse to INO in an endotoxin-induced animal lung injury model Materials and methods Animals After...
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Báo cáo y học: "Bench-to-bedside review: Inhaled nitric oxide therapy in adults" pot

Báo cáo y học:
... R, Ullrich R: Inhaled nitric oxide therapy in adults: European expert recommendations Intensive Care Med 2005, 31:1029-1041 Griffiths MJ, Evans TW: Inhaled nitric oxide therapy in adults N Engl ... survey of the use of inhaled nitric oxide in the ICU Working Group on Inhaled NO in the ICU of the European Society of Intensive Care Medicine Intensive Care Med 1998, 24:864-877 George I, Xydas ... Conference (definitions); ALI, acute lung injury; ARDS, acute respiratory distress syndrome; CXR, chest x-ray; FiO2, fraction of inspired oxygen; ICU, intensive care unit; iNO, inhaled nitric oxide; ...
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Composite controlled release system of nitric oxide for cardiovascular tissue engineering application

Composite controlled release system of nitric oxide for cardiovascular tissue engineering application
... COMPOSITE CONTROLLED RELEASE SYSTEM OF NITRIC OXIDE FOR CARDIOVASCULAR TISSUE ENGINEERING APPLICATION ZHANG QINYUAN B.Eng (Hons), National University of Singapore A THESIS SUBMITTED FOR THE ... illustration of the proposed composite controlled release system of NO is depicted in Figure 1-1 There are three main parts in the composite system: supportive film, NO donor, and host of NO donor ... components Therefore, choices of appropriate materials and techniques with fewer limitations are crucial for the development of composite vascular grafts 2.4 Nitric Oxide Nitric oxide (NO) is a...
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