Effect of secondary structure on biological activities of antimicrobial peptides

Toxicology and pharmacology investigation of 2 phenylaminophenylacetic acid derived NSAIDs implication of chemical structure on biological outcomes

Toxicology and pharmacology investigation of 2 phenylaminophenylacetic acid derived NSAIDs implication of chemical structure on biological outcomes
... 23 2. 2.1 Extraction of diclofenac (3) from Voltaren tablets 24 2. 2 .2 Synthesis of compounds 1, and 25 2. 2 .2. 1 Synthesis of 2- iodophenyl-N, N-dimethylacetamide (25 ) 25 2. 2 .2. 2 General ... Statement of purpose 19 Chapter Design and Synthesis of 2- Phenylaminophenylacetic Acid Derived Compounds 22 2. 1 Introduction 22 2. 2 Experimental methods 23 2. 2.1 ... 72 4 .2. 2.1 Cell harvesting and lysis 72 4 .2. 2 .2 SDS-PAGE and Transfer 72 4 .2. 2.3 Detection 73 4 .2. 3 Cell-based COX-1 inhibition assay 73 4 .2. 4 Cell-based COX-2...
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Báo cáo y học: "The effect of antimicrobial resistance on patient outcomes: importance of proper evaluation of appropriate therapy" pps

Báo cáo y học:
... divorced from consideration of the effect of the therapy received In addition to assessing delay in institution of therapy, analysis of the effect of appropriateness of therapy must take into account ... but clinically problematic, the effect on mortality of delay in receiving truly appropriate therapy, and the potential impact of this delay on the results of the multivariable analysis, remain ... therapy considered appropriate according to the study definitions (79% by 24 hours and 87% by 48 hours) We therefore have only limited ability to determine the impact of resistance on mortality insofar...
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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 1

Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 1
... bilayer 14 1 CHAPTER CONCLUSION AND OUTLOOK 8 .1 Conclusion 8.2 Outlook 18 4 18 4 18 9 Bibliography 19 2 14 1 14 1 14 5 14 5 14 5 14 6 14 8 15 1 15 3 15 5 15 5 15 8 16 3 16 8 17 0 17 0 17 1 17 6 18 2 iv Summary Antimicrobial ... antimicrobial peptides 75 78 78 79 84 84 84 87 89 90 90 92 94 95 95 97 99 10 0 10 1 10 1 10 2 10 5 10 5 11 3 11 9 12 3 12 8 13 1 13 1 13 2 13 2 13 6 iii CHAPTER INTERACTION BETWEEN ANTIMICROBIAL PEPTIDES AND LIPID ... insert into the membrane core The hydrophobic part of the antimicrobial peptides interacts with the hydrophobic alkyl chains of the lipids and the hydrophilic part of the antimicrobial peptides...
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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 3

Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 3
... 7 .3 Results and discussion 7 .3. 1 Isotherm studies of V4 interacting with POPG and POPC 7 .3. 1.1 Isotherms of lipid monolayers The surface pressure (π) and molecular area (A) isotherms for POPG and ... difference between the POPG and POPC isotherms, indicative of the negligible effect of electrostatic interaction 145 Fig 7.1 Isotherms of POPG and POPC monolayers 7 .3. 1.2 Isotherms of mixed lipid/ V4 monolayers ... penetration process 169 7 .3. 3 AFM studies of antimicrobial peptides interacting with lipid monolayers 7 .3. 3.1 AFM images of pure lipid monolayers The morphology of pure POPG, POPC and DPPG monolayers...
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Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 2

Investigation of the interaction of antimicrobial peptides with lipids and lipid membranes 2
... fitting The second particle exhibited an F2 of 4 .2 % and an increase in the fluorescence yield compared to TMR of Q2/Q1 of 3 .21 90 Fig 5.5 Comparison of ACFs of V4-TMR and the complexes of V4-TMR with ... 0.6 and 1.7 ms, similar to the expected diffusion time of lipid SUVs However, F2 and N2 differed markedly depending on the lipid used In the group of lipids with unsaturated lipid tails, the ... 1.73 ± 0 .28 0 .27 0 ± 0.004 V4-TMR :lipid A 11 .2 ± 1.3 0.095 ± 0.009 52. 5 c 1.89 ± 0.17 43.5 ± 4.3 2. 52 ± 0 .28 0.050 ± 0.009 V4-TMR:PC 4.3 ± 0 .2 0.058 ± 0.0 02 52. 5 c 1.87 ± 2. 59 4 .2 ± 1 .2 3 .21 ± 0.37...
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Tài liệu Báo cáo " The effect of cobalt substitution on structure and magnetic properties of nickel ferrite " pptx

Tài liệu Báo cáo
... addition of Co2+ ion content, which may be attributed to the ionic radii of constituent ions causing increase in lattice parameter and the densities of pure cobalt ferrite (5.29 g/cm3) and pure nickel ... temperature.These plots show that an increase in Co2+ doping yields monotonic increase in the saturation magnetization of Niferrite which may be due to the substitution of Ni2+ ions by Co2+ on the octahedral ... to the contribution of magnetocrystalline anisotropy of material, the second one is given by shape anisotropy of crystalline particles (domains) and the third one is orginated from the action of...
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Tài liệu Báo cáo khoa học: Salt-induced formation of the A-state of ferricytochrome c – effect of the anion charge on protein structure docx

Tài liệu Báo cáo khoa học: Salt-induced formation of the A-state of ferricytochrome c – effect of the anion charge on protein structure docx
... the anion protein interactions in A-state stabilization Competition among anions To better define the effect produced by monovalent anions on the sulfate-induced A-state of cytochrome c, we monitored ... environment of the sulfate-induced A-state of cytochrome c, as observed from changes induced in the 416 nm Cotton effect (sulfate concentration: 50 mM) The effect of sulfate (.) concentration on the ... eukaryotic c class cytochromes [27]; anions exert a strong influence on the lysine residues of cytochrome c, and significantly affect the structure and the functional properties of the protein, as the conserved...
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Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt

Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
... presence of EDTA The rough S minnesota LPS increased the initial fast phase of the reaction, but decreased the rate of the slow phase of oxidation in the presence of EDTA A comparison of rough and smooth ... reported that the oxidation of the a chains of Hb A0 was 10 times faster than that of the beta chains and that the oxidation of the beta chains was not influenced by pH The biphasic reaction was shown ... rough and smooth S minnesota was solely due to a sharp increase in the initial rate (Fig 5) A comparison of the effects of the rough and smooth LPSs of E coli and S minnesota on the oxidation of...
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Báo cáo khoa học: Effect of valine 106 on structure–function relation of cytosolic human thymidine kinase Kinetic properties and oligomerization pattern of nine substitution mutants of V106 ppt

Báo cáo khoa học: Effect of valine 106 on structure–function relation of cytosolic human thymidine kinase Kinetic properties and oligomerization pattern of nine substitution mutants of V106 ppt
... following nine mutations: V106A, V106G, V106H, V106I, V106K, V106L, V106M, V106Q and V106T We then characterized the enzymatic properties of the mutant enzymes The apparent native sizes of the –ATP ... of dTMP formation and thymidine concentration Open symbols, +ATP forms; closed symbols, –ATP forms (A) Dimeric enzymes: V106WT, V106A, V106I and V106T; (B) tetrameric enzymes: V106G, V106H, V106K, ... enzymes, containing V106G, V106H, V106K, V106L and V106Q, have properties similar to V106M, i.e in both the absence and presence of ATP they have low K0.5 values for thymidine, % 0.3–1.2 lM, and Hill...
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Báo cáo Y học: Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII pot

Báo cáo Y học: Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII pot
... the effect Mutations of yeast RNase H2 and archaeal RNase HII of a disease-causing mutation on the activity, stability, and structure of human RNase H2 and the role of the glycine residue fully ... or interactions with other proteins might be perturbed in human cells Alternatively, the mutations in the accessory proteins may not have the same consequences in the yeast enzyme as they in the ... the substrate binding affinity Binding analyses using BIAcore system To examine whether the mutation of Gly10 to Leu or Pro affects the substrate binding affinity of the protein, the interactions...
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effect of processing parameters on pore structure and thickness of anodic

effect of processing parameters on pore structure and thickness of anodic
... equilibrium of oxidation and chemical dissolution The dynamic equilibrium of the oxide formation (highly dependent on the acid concentration and availability of oxygen ions) and dissolution (relatively ... molecules once pass into one end (inner) of the pore would only come out from the other end (outer) of the pore without diffusing out from the middle of the pore- tunnel The relationship of membrane thickness ... acid concentration Concentration of the acids also influenced the pore size in a way that higher acid concentration increased the rate of oxidation than dissolution thereby decreasing the pore...
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Báo cáo khoa học: The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the Vibrio cholerae ToxR protein pot

Báo cáo khoa học: The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the Vibrio cholerae ToxR protein pot
... surface and the consequent effect on the structure of the protein Towards achieving this goal we studied the effect of ZnO NPs on the structure of ToxRp, alone and in the presence of denaturing ... changes of the ToxRp protein of V cholerae Based on the thermodynamic parameters of binding one can speculate on the nature of the interaction between ToxRp and ZnO NPs, and 4190 the consequent effect ... al Effect of ZnO NPs on ToxRp Fig Far-UV CD spectra of ToxRp in the presence of varying concentrations of KCl in the absence and presence of ZnO NPs (Fig S3) indicated that the effect of NPs on...
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Báo cáo khoa học: Effect of mutations in the b5–b7 loop on the structure and properties of human small heat shock protein HSP22 (HspB8, H11) pptx

Báo cáo khoa học: Effect of mutations in the b5–b7 loop on the structure and properties of human small heat shock protein HSP22 (HspB8, H11) pptx
... Ao and At are the intensities of the band of intact protein at the beginning of trypsinolysis and at the fixed time of trypsinolysis) against the time of incubation (Fig 8D) The apparent rate constants ... are same as given in (A) Point mutations of the b5–b7 loop of human HSP22 their secondary structure and on superposition of the mammalian protein sequence on the 3D structure of already crystallized ... to provide new information on the structure of sHsp and to shed new light on their role in the development of human congenital diseases Point mutations of the b5–b7 loop of human HSP22 Results...
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Báo cáo Y học: The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme pdf

Báo cáo Y học: The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme pdf
... representing the strongest effect on the 11bhydroxylation activity of all single mutants investigated here When both mutations were introduced into CYP11B2, the 11b-hydroxylation capacity was additionally ... strongly improve the substrate conversion in relation to the CYP11B2 wild-type protein (Fig 3) By replacing the amino acids in positions 112 and 147 of CYP11B2 with those found in mouse, rat and ... residues of CYP11B2 implicated in the regulation of individual reaction steps Swapping the amino acid at position 147 from CYP11B2 to CYP11B1, led to a stronger increase in the hydroxylation at the...
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Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx

Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx
... xCTBP/xALDH1 There are many reports of the inhibitory effects of thyroid hormones upon the activity of several dehydrogenases: pig heart malic dehydrogenase [34], beef liver glutamic dehydrogenase ... flavopiridol-binding protein FEBS Lett 454, 100–104 22 Yamauchi, K & Tata, J.R (2001) Characterization of Xenopus cytosolic thyroid- hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity Chem ... heart malate dehydrogenase [37], horse and human alcohol dehydrogenases [38–40] and human aldehyde dehydrogenases [31] These observations raise the possibility of the presence of a dehydrogenasespecific...
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