Hydrogen bonding in DNA base pairs

Báo cáo khoa học: Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA pptx

Báo cáo khoa học: Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA pptx
... damaged or inappropriate bases in DNA is base excision DNA repair (BER) [8–10] The initial step of BER involves enzymatic activities that process the N-glycosylic bonds linking the target bases and ... structurally distinct abasic sites, known as oxidized abasic sites Oxidized abasic sites include lesions at DNA strand breaks, such as 3¢-phosphoglycolate esters and abasic residues in an uninterrupted ... the excision step of long patch mammalian base excision repair J Biol Chem 274, 13741–13743 41 Bennett SE, Sung JS & Mosbaugh DW (2001) Fidelity of uracil-initiated base excision DNA repair in DNA...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc

Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... HsRad51 to examine whether these loops are actually involved in DNA binding Because aromatic residues are involved in the ssDNA binding by bacterial single stranded DNA- binding protein (SSB) and ... mutagenesis across the HsRad51 -L1 loop, and tested the interaction between the L1 loop and DNA A D B E Involvement of the L1 loop-Tyr232 residue in DNA binding The L1 loop of HsRad51 contains an aromatic ... the direct involvement of the Phe279 residue within the HsRad51 -L2 loop in DNA binding is less evident, because the F279A mutation in the L2 loop did not reduce the DNA- binding ability of HsRad51...
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Báo cáo khoa học: Short hydrogen bonds in proteins Sathyapriya Rajagopal and Saraswathi Vishveshwara pot

Báo cáo khoa học: Short hydrogen bonds in proteins Sathyapriya Rajagopal and Saraswathi Vishveshwara pot
... Short hydrogen bonds in proteins Although short hydrogen bonds have been reported in several proteins and their implication in catalysis has been discussed in detail, we noticed ... (B) The frequency of SHBs as a 1821 Short hydrogen bonds in proteins S Rajagopal and S Vishveshwara Table Overview of SHB in proteins Total number of proteins in the dataset ¼ 948; total number ... 1819–1832 ª 2005 FEBS S Rajagopal and S Vishveshwara Short hydrogen bonds in proteins copperamine oxidase, like simultaneous bend of strands (Fig 13, a), strands moving away in different directions...
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Short hydrogen bonds in proteins potx

Short hydrogen bonds in proteins potx
... Short hydrogen bonds in proteins Although short hydrogen bonds have been reported in several proteins and their implication in catalysis has been discussed in detail, we noticed ... terminus of helices in proteins J Mol Biol 322, 871–880 Manikandan K & Ramakumar S (2004) The occurrence of C– H…O hydrogen bonds in alpha-helices and helix termini in globular proteins Proteins ... Saenger W (1991) Hydrogen Bonding in Biological Structure Springer, Berlin Steiner T & Koellner G (2001) Hydrogen bonds with p acceptors in proteins: Frequencies and role in stabilising local 3D...
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A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx

A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... bridging the A and G b-strands of the I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into the role of solvent hydrogen bonds in protein unfolding, ... separating b-strands In Figure B, we define the pulling coordinate for the A and G b-strands as the distance between the first amino acid of strand A (Y9) and the last amino acid of strand ... molecular dynamics (SMD) simulations have shown that for I27 rupture of a pair of hydrogen bonds in the A and B b-strands near the amino terminus of the protein domain causes an initial extension of...
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Molecular Biotechnology-Lession 3: Basic techniques in DNA technology ppt

Molecular Biotechnology-Lession 3: Basic techniques in DNA technology ppt
... Annealing: - Denature DNA, 950C, 30s-1min - Annealing, 55-60oC, 1min  Step 3: Extension, 70-72oC, 30s-1min Go to step 2, 32 cycles  Step 4: Holding, 4oC, 0s  Primers (short DNA fragments) containing ... 30s-1min - Annealing, 55-60oC, 1min Step 3: Extension, 70-72oC, 30s-1min Go to step 2, 32 cycles  Step 4: Holding, 4oC, 0s  Exponentially amplifying a single or some piece of DNA generating thousands ... copies of DNA  Total copies = 2n where n is the number of cycles to copy DNA  So basically it is the cycles of heating and cooling (thermal cycling)  Applications of PCR  DNA cloning  DNA based...
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Báo cáo khoa học: Interaction of selenium compounds with zinc finger proteins involved in DNA repair pdf

Báo cáo khoa học: Interaction of selenium compounds with zinc finger proteins involved in DNA repair pdf
... proteins where zinc is complexed through four invariant cysteine and/or histidine residues, forming a zinc finger domain that is mostly involved in DNA binding but also in protein–protein interactions ... the coupling of zinc- binding structures (either in MT or in zinc finger proteins) by selenium compounds with the cellular redox system GSH/GSSG, reducible selenium may be regenerated within catalytic ... folding of the minimal DNAbinding domain [50]; substitution of any of its zinccomplexing cysteines (Cys105, Cys108, Cys126 and Cys129) leads to diminished DNA binding and a severe reduction in...
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Báo cáo khoa học: Histone H2A phosphorylation in DNA double-strand break repair pot

Báo cáo khoa học: Histone H2A phosphorylation in DNA double-strand break repair pot
... DNA 3233 H2A phosphorylation and DNA repair break was impaired in strains with mutations in either H2A S129 or the Mec1 and Tel1 kinases [29,30] SwrC SwrC, the third Arp4-containing complex in ... at DNA breaks, maintains checkpoint arrest, and in uences DNA repair in fission yeast Mol Cell Biol 24, 6215–6230 Madigan JP, Chotkowski HL & Glaser RL (2002) DNA double-strand break- induced phosphorylation ... the H2A or H2AX tail that were either unmodified or contained a phosphoserine residue in the SQ motif Proteins containing known phosphoserine ⁄ threonine binding motifs such as BRCT or FHA domains...
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Báo cáo hóa học: " Research Article Short Exon Detection in DNA Sequences Based on Multifeature Spectral Analysis" potx

Báo cáo hóa học:
... Journal on Advances in Signal Processing Exon1 Intron1 Exon1 Exon2 Exon2 Intron2 Exon3 Exon3 Figure 1: A eukaryotic gene and the splicing process to distinguishing exonic and intronic regions is based ... base along the DNA sequence in the exon detection process In addition, we analyze multiple input signals at the same time since they all contain the 1/3 frequency component A moving window is ... superior in short exon detection to the existing signal processing -based techniques Further increase in detection accuracy is possible if we combine the proposed method with supervised machine learning...
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Báo cáo hóa học: " Research Article A Novel Signal Processing Measure to Identify Exact and Inexact Tandem Repeat Patterns in DNA Sequences" potx

Báo cáo hóa học:
... single base repeat pattern, for instance, repeat like AAAAA in DNA sequence ACGACAAAAACAACG because the repeat pattern of period is of no interest In step (4), the energy of the input signal is decomposed ... of inexact repeats An STPT-based approach for finding tandem repeats in DNA sequence is presented in [13] Both DFT- and STPTbased techniques suffer from one major disadvantage while detecting inexact ... subspaces from to Pmax The value πW,i acts as an indicator for identifying the local periodicities of the input sequence and is said as tandem repeat coefficient And finally in step (6), we obtain a...
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Báo cáo hóa học: " Research Article A Novel Signal Processing Measure to Identify Exact and Inexact Tandem Repeat Patterns in DNA Sequences" pdf

Báo cáo hóa học:
... single base repeat pattern, for instance, repeat like AAAAA in DNA sequence ACGACAAAAACAACG because the repeat pattern of period is of no interest In step (4), the energy of the input signal is decomposed ... of inexact repeats An STPT-based approach for finding tandem repeats in DNA sequence is presented in [13] Both DFT- and STPTbased techniques suffer from one major disadvantage while detecting inexact ... subspaces from to Pmax The value πW,i acts as an indicator for identifying the local periodicities of the input sequence and is said as tandem repeat coefficient And finally in step (6), we obtain a...
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Báo cáo vật lý: "Using of HPLC Analysis for Evaluation of Residual Monomer Content in Denture Base Material and Their Effect on Mechanical Properties" pptx

Báo cáo vật lý:
... sample of PMMA for self-cure denture base material HPLC Analysis for Evaluation 132 Table 1: The results of MMA content of denture base materials compared with ISO standard Denture base material ... properties of denture base material related to the effect of level of residual monomer, and concluded that the percentage of higher levels of residual monomer effected on the tensile properties of denture ... approximately and 10–14 min, respectively 2.2.3 Determination of residual monomer in the denture base materials using HPLC HPLC was used to quantity the residual methyl methacrylate (MMA) content in the...
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Báo cáo khoa hoc:" An expression of mixed animal model means equations to account for different and variances in the base" pps

Báo cáo khoa hoc:
... valid to assume that the breeding values of the base animals have the same mean and variance, and that the genetic variance of the base generation is twice that of the Mendelian variance In a ... set up the equations corresponding to an animal model with base animals treated as fixed and an additive genetic animal model with groups and relationships, respectively Cantet and Fernando [1] ... given THEORY The usual animal model expression can be written as: where y is the vector of records; b is the vector of fixed effects; a is the random b vector of breeding values of base animals;...
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Báo cáo y học: " Usefulness of case reports to improve medical knowledge regarding trigemino-cardiac reflex in skull base surgery" doc

Báo cáo y học:
... of case reports to improve medical knowledge regarding trigemino-cardiac reflex in skull base surgery Journal of Medical Case Reports 2011 5:149 Submit your next manuscript to BioMed Central and ... considered one of the great problems in modern skull base surgery (see, for example, [14]) This example points out the outstanding importance of case reports to improve medical knowledge not only in past ... nowadays We hope that this story of success may inspire others to publish and especially to deeply analyze their special cases that deal with not yet published clinical features; this is one of...
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