Methotrexate

Methotrexate và viêm khớp dạng thấp

Methotrexate và viêm khớp dạng thấp
... Bệnh nhân mắc bệnh viêm khớp dạng thấp cần tuân thủ điều trị thầy thuốc Một số thuốc điều trị bệnh viêm khớp dạng thấp methotrexate Methotrexate thuốc chống chuyển hóa đồng dạng acid folic ức ... Việt Nam, bệnh viêm khớp dạng thấp thường gặp nhóm bệnh thấp viêm Bệnh khớp mạn tính, có đợt tiến triển kịch phát Bệnh hay gặp nữ liên quan đến lứa tuổi Mắc bệnh lâu ngày khớp bị biến dạng, làm cản ... chế dihydrofolate Ngày nay, methotrexate khuyến cáo dùng viêm khớp dạng thấp thể nặng mà không đáp ứng với điều trị cổ điển phụ thuộc corticoid Bệnh nhân lưu ý sử dụng methotrexate nên uống bổ sung...
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Báo cáo khoa học: Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells docx

Báo cáo khoa học: Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells docx
... Functional validation of IMPDH2 HT29- R cells were incubated with increasing concentrations of chemical inhibitors of IMPDH activity, benzamide riboside, tiazofurin or mycophenolic acid, in the ... Survivin is a member of the inhibitor of apoptosis protein (IAP) family [28] which directly inhibits caspase-3, -7 [29–31], and caspase-9 activities [32,33] Moreover, survivin indirectly inhibits ... Benzamide riboside, tiazofurine and mycophenolic acid are potent inhibitors of this enzymic activity and phase II ⁄ III clinical trials that have been conducted with them as anticancer drugs in...
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THÔNG ỐNG DẪN TRỨNG SAU ĐIỀU TRỊ NỘI KHOA THAI NGOÀI TỬ CUNG BẰNG METHOTREXATE ppt

THÔNG ỐNG DẪN TRỨNG SAU ĐIỀU TRỊ NỘI KHOA THAI NGOÀI TỬ CUNG BẰNG METHOTREXATE ppt
... thai, tỷ lệ thông ống dẫn trứng Về tỷ lệ thai tử cung tái phát ống dẫn trứng bảo tồn chấp nhận KẾT LUẬN Sau điều trị theo dõi từ lúc tiêu thai đến lúc mang thai lại, với ti lệ thông ống dẫn trứng ... dẫn trứng Tắc ống dẫn trứng Các trường hợp có ống dẫn trứng bị tắc chủ yếu tắc ứ dịch đoạn xa Đa số ống dẫn trứng bên đối diện bình thường (69.2%) Bảng Tình trạng có thai vòng tháng sau điều trị ... Kết liệu pháp nội khoa sánh với kết phương pháp nội soi ổ bụng bảo tồn với kỹ thuật xẻ ống dẫn trứng lấy khối thai Tỷ lệ có thai lại năm sau điều trị 21 trường hợp có thai lại tử cung chiếm tỷ...
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Báo cáo y học: "Etanercept versus etanercept plus methotrexate: a registrybased study suggesting that the combination is clinically more efficacious" pptx

Báo cáo y học:
... of pain, and the physician global assessment all revealed statistically significantly better results for the combination therapy as compared with the monotherapy after months The other Available ... significant While the STURE database is part of the AntiRheumatic Therapies in Sweden national biologicals safety registry, the present study was performed using only data collected and analysed at the ... diseasemodifying antirheumatic drug therapy and, on the other hand, combination therapy where etanercept is added to established MTX therapy This situation does not directly translate into a clinical decision-making...
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Báo cáo y học: "Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols" docx

Báo cáo y học:
... = mild synovial hypertrophy (< cell layers) with few inflammatory cells; = moderate synovial hypertrophy (< 20 cell layers) with accumulation of inflammatory cells into intrasynovial cysts; = ... preventing the development of pathology in the Tg197 transgenic murine model of RA, in which inflammatory polyarthritis is clinically detectable at weeks of age, with swelling and deformation of ... Tg197 mice The disease modifying effect of diacerein in Tg197 mice, as assessed by clinical and histopathologic analysis, was compared with that of anti -inflammatory agents (i.e dexamethasone, methotrexate, ...
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Báo cáo y học: "Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study" ppt

Báo cáo y học:
... after initiation of infliximab therapy Reduced vascularity In both lesional dermis and synovial tissue, vascularity was significantly diminished after infliximab therapy, as shown by examination of ... lesional skin and synovial biopsies (integrated optical density/mm2) before and weeks after initiation of infliximab therapy The data are expressed as mean ± standard error of the mean ICAM, intercellular ... 137:245-254 Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, Murray JS, Siahaan TJ: Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases Med...
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Báo cáo y học: "Molecular action of methotrexate in inflammatory diseases" ppt

Báo cáo y học:
... diminish inflammation in the joint is by diminishing cytokine production Numerous studies have demonstrated diminished levels of inflammatory cytokines in the serum of patients The adenosine A2A ... adenosine deaminase, an adenosine-metabolizing enzyme, suggesting that adenosine is indeed responsible for the anti -inflammatory effects of methotrexate in vivo [36] An interesting study by Silke ... is a primary or secondary effect of adenosine The recent success of anti-TNF therapy highlights the role of cytokines as important mediators of inflammatory activity Not surprisingly, methotrexate, ...
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Báo cáo y học: "Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure" potx

Báo cáo y học:
... JS: Laboratory testing in rheumatoid arthritis patients taking disease-modifying antirheumatic drugs: clinical evaluation and cost analysis Arthritis Rheum 2002, 47:181-188 Arnett FC, Edworthy SM, ... and safety of reemployed DMARDs in comparison with the application of the same DMARD in earlier years, identifying patients with a history of prior DMARD failure in a large observational data ... DMARD at our clinics In these patients, the average delay between disease onset and DMARD initiation was 3.7 years, which is in accordance with the pyramid approach of previous years For the remaining...
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Báo cáo y học: "Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis" pps

Báo cáo y học:
... similar roles in regulating inflammation in the peritoneum We examined the pharmacologic mechanism by which methotrexate diminishes inflammation in the thioglycollate-induced peritoneal inflammation ... and in vivo studies showed that methotrexate is ineffective in the presence of antagonists of adenosine or adenosine deaminase (the enzyme responsible for the deamination of adenosine to inosine) ... both A2A and A3 adenosine receptors are involved in methotrexate- mediated suppression of air pouch inflammation [17] but, as reported here, only A2A receptors are involved in methotrexate- mediated...
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Báo cáo y học: "Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression" doc

Báo cáo y học:
... anti-inflammatory effect of adenosine is mediated via A2A and the A3 adenosine receptors [8,9] The highly selective A3 adenosine receptor (A3AR) agonist IBMECA (1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-9-yl]N-methyl-β-D-ribofura-nuronamide) ... explore the mechanism underlying the efficacy of the combined treatment, we first examined the mode of action of MTX It acts as an antagonist of folic acid, subsequently inhibiting the synthesis of ... environment [19] The working hypothesis of the present study was that the increase in adenosine level may act via an autocrine pathway and induce the expression of its own receptors, in this case A3AR Indeed,...
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Báo cáo y học: "Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies" ppt

Báo cáo y học:
... cross-sectional and longitudinal study showed no abnormality in EBV viral load or EBV-specific T-cell response in patients with RA or SpA at baseline or after treatment with MTX or anti-TNF drugs In contrast ... between the Epstein-Barr virus viral load and Epstein-Barr virus- specific T-cell response Correlation between the number of IFNγproducing T cells and the Epstein-Barr virus (EBV) viral load EBV-specific ... cross-sectional study Epstein-Barr virus load in peripheral blood mononuclear cells in the cross-sectional study Epstein-Barr virus (EBV) load distribution in control individuals (n = 15), spondylarthropathy...
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Báo cáo y học: "Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study" pptx

Báo cáo y học:
... including older age and disease severity (HAQ) are associated with the presence of the MetS in patients with RA More importantly, methotrexate therapy appears to significantly decrease Table Prevalence ... commencement of the study Patient data was obtained via case note analysis and a faceto-face interview performed by a rheumatologist The dual approach facilitated the documentation of a detailed history ... against a potential anti-inflammatory mechanism of action of methotrexate In view of patient age acting as an independent predictor for the MetS, we performed a further subanalysis to examine the...
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Báo cáo y học: "Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome" potx

Báo cáo y học:
... prednisolone only, methotrexate only, sulfasalazine only, hydroxychloroquine only, tumour necrosis factor-blocking agents, combination of disease-modifying antirheumatic drugs, pack-years, smoking, ... DMARD, diseasemodifying antirheumatic drug; ESR, erythrocyte sedimentation rate; HCQ, hydroxychloroquine; MTX, methotrexate; RA, rheumatoid arthritis; SSZ, sulfasalazine; TNF, tumour necrosis factor ... deviations) in cases of normal distribution or as medians (interquartile ranges) in cases of nonnormal distribution BMI, body mass index; CRP, C-reactive protein; DAS28, disease activity score using...
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Báo cáo y học: "Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome – authors’ respons" pps

Báo cáo y học:
... Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study Arthritis Res Ther 2008, 10:R145 Page of (page ... reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60: more than just an anti-inflammatory effect? A crosssectional study Arthritis Res Ther 2009, 11:R110 ... Arthritis Research & Therapy Vol 11 No Toms et al Competing interests The authors declare that they have no competing interests Acknowledgements This work is supported by an Arthritis Research...
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báo cáo khoa học: "Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate" docx

báo cáo khoa học:
... used two colon cancer cell lines: the human HT29 and the murine DHDK12 pro-b (Pr Martin, Dijon; France) cell lines Cell lines were cultured in DMEM medium containing 10% calf serum/penicillin (50 ... difference in retroviral gene transfer improvement between DHDK12 and HT29 cell lines after cell synchronization by MTX These two colon cancer cell lines exhibit a different pattern of cell cycle ... cell synchronization may improve the efficacy of retroviral suicide gene transfer in a human and a murine colon cancer cell lines Because Page 11 of 12 the effect of cell synchronization on retroviral...
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