... sulfur content in their N- and C-terminus, which plays an important role in interacting with hair keratin-associated proteins via disulfide bindings [6, 7] All the keratin proteins are composed ... recessively-inherited mutation in ADAM17 gene encoding TACE have been shown to cause inflammatory skin and bowel 20 Current Genetics in Dermatology disease (MIM 614328) in humans, and affected individuals ... of an N-terminal rod domain, a central rod domain, and a C-terminal tail domain Importantly, the N-terminal and the C-terminal regions of the rod domain are highly conserved in amino acid sequences,...