... et al.: A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant ... with estramustine- based combinations and the activity of combined navelbine and mitoxantrone, supporting the testing of combination therapy with estramustine, mitoxantrone, and vinorelbine in patients ... or 13-cis retinoic acid, interferon- alpha2b with paclitaxel (Arm B) Figure Progression Free Survival in patients treated with mitoxantrone, estramustine and vinorelbine (Arm A) or 13-cis retinoic...