... Inhibition of tissue- factor- factor VIIa-catalysed factor X activation by factor Xa -tissue factor pathway inhibitor J Biol Chem 274, 28225–28232 22 Tikhonov, A. N., Vasil’eva, A. V & Sveshnikov, A. G (1985) ... extrinsic pathway factor Xa formation by tissue factor pathway inhibitor J Biol Chem 273, 4378–4386 Kuharsky, A. L & Fogelson, A. L (2001) Surface-mediated control of blood coagulation: the role of binding ... factor X activation in the absence of factor Xa at the initiation point of the reaction Yet this mechanism based on the hypothesis of the interaction between TFPI and Xa–VIIa–TF cannot explain...