16168 drugs

16168 drugs

16168 drugs
... harmful effects of drugs TASK WRITING Write a composition about this topic of drugs Imagine you are talking to your children about drugs How would you prevent your children of taking drugs? (50-60 ... Introduction: Introduce the topic and the purpose of it - Development: Show your ideas about taking drugs - Conclusion: Summarize the main ideas Remember using the tenses seen in class (simple and...
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Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"

 Báo cáo y học:
... cytotoxic drugs by increasing the sensitivity of the tumors to these agents Indeed, it has been shown that PARP-1 inhibitors not only significantly enhance the anti-tumor efficacy of the alkylating ... mice are viable and healthy [32], and inhibitors that are specific for PARP-1 are relatively non-toxic and not directly damage DNA, PARP-1 inhibitors might be both safe and effective for BRCA1/2-associated ... in DNA These SSBs result in formation of double strand breaks (DSBs) when they meet replication forks (B) In the presence of wild type BRCA1 and BRCA2, DSBs can be efficiently repaired by RAD51...
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Detection of Antiviral Drugs Oseltamivir Phosphate and Oseltamivir Carboxylate in Neya River, Osaka, Japan

Detection of Antiviral Drugs Oseltamivir Phosphate and Oseltamivir Carboxylate in Neya River, Osaka, Japan
... owing to H1N1 influenza pandemic and drastic increase in antiviral drugs consumption It is therefore worthy to monitor the drugs in surface waters in the winter season to get more insight of ... location of the sampling sites with the map of Japan inset The Neya River is located in Osaka Prefecture of Japan as shown in the figure Details of the sampling stations and dates are illustrated in ... Osaka, and the significance of these drugs during the period of seasonal influenza and H1N1 influenza pandemic (September 2009 to February 2010) MATERIALS AND METHODS Chemicals and Reagents Oseltamivir...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 17)

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 17)
... sampling until injection to GC, and from the standard solution to a test specimen) In principle, the sampling, extraction and GC analysis should be made at low temperature, in a gastight state and ... transformation in rats J Pharm Sci 74:780–782 10) Kielbasa WB, Bauer JA, Fung HL (1999) Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations J Chromatogr ... concentration of an alkyl nitrite on the horizontal axis and peak area on the vertical axis The concentration of the analyte in a specimen is calculated using the calibration curve i Assessment and some...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 67)

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 67)
... GC/MS analysis for DAEMS in serum (a) a total ion chromatogram (TIC) and a mass chromatogram; (b) an EI mass spectrum of DAEMS; (c) a CI mass spectrum of DAEMS Poisoning case, and toxic and fatal ... GC/MS analysis for EMPA in serum (a) a TIC and mass chromatograms; (b) an EI mass spectrum of the t-BDMS derivative of EMPA; (c) a CI mass spectrum of the same derivative of EMPA data of animals According ... concentrations of DAEMS are spiked into blank serum specimens containing a fixed amount of DAEMO (IS) each and extracted as described before Since the base peaks of DAEMS and DAEMO (IS) equally appear...
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Color Atlas of Pharmacology (Part 14): Drugs used in Hyperlipoproteinemias

Color Atlas of Pharmacology (Part 14): Drugs used in Hyperlipoproteinemias
... cholesterol-lowering drugs Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 156 Drugs used in Hyperlipoproteinemias liver meets its increased ... ingestion an unpleasant experience The statins, lovastatin (L), simvastatin (S), pravastatin (P), fluvastatin (F), cerivastatin, and atorvastatin, inhibit HMG CoA reductase The active group of ... production of urine may cease (anuria) By means of diuretics an attempt is made to maintain urinary flow Use of either osmotic or loop diuretics is indicated Massive use of diuretics entails a hazard of...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 20)

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 20)
... 188 Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimensa Reagents and their preparation • • • Extraction and purification of cannabinoids [3]: Cannabis sativa L is ... construct a calibration curve with cannabinoid concentration on the horizontal axis and with peak area ratio of a cannabinoid to IS on the vertical axis GC analysis of cannabinoids in plant specimens ... side-chain hydroxylated ∆6-tetrahydrocannabinol metabolites Acta Pharm Suec 16:21–33 9) Yamamoto I, Watanabe K, Narimatsu S et al (1990) A GC-MS method for determination of ∆9-tetrahydrocannabinol-11-oic...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)
... Main metabolic pathways of morphine, heroin and codeine The thick and thin arrows show the main and minor metabolic pathways, respectively ⊡ Figure 3.1 196 Morphine and its analogues GC and ... Qualitative analysis is made by the comparison of the retention time of a peak of a specimen with that of the authentic standard and also by the confirmation of the absence of such a peak in a ... morphine, codeine and tetrahydropapaveroline in Parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine therapy: a possible biosynthetic pathway of morphine from L-3,4-dihydroxyphenylalanine...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 70)

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 70)
... normal cyanosis headache, dyspnea, tachypnea, tachycardia and hypertension mental derangement, listlessness and metabolic acidosis coma, convulsive attack and hypotension death A poisoning case ... centrifugation at 3,000 rpm for min, 1- or 4- L of the upper layer is injected into GC Various known amounts of nitrate and a fixed amount of IS are added to blank specimens and processed in the same way ... of the oxidation of nitrite into nitrate and the same extractions as those for nitrate A calibration curve for nitrite using blank specimens and IS is also prepared for quantitation in the same...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 71 and End)

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 71 and End)
... amanitin 473, 477, 479 amido-type local anesthetic 385 1-amino-4-phenylbutane 173 2-amino-6-hydroxymethyl8-hydroxyquinazoline 482 aminomethyl phosphonic acid 546 7-aminonitrazepam 19 5-aminoquinoline ... alminoprofen 325, 330, 332 alprazolam 284, 285, 290 alternative specimens Amanita neoovoidea 480 Amanita pantherina 469 Amanita phalloides 469 Amanita verna 469, 474 Amanita virosa 469, 473 amanitin ... N-chloromethylphthalimide 327 N-de-ethyl-LSD 228 n-decane 165 n-heptane 165 n-hexane 165 N-methyl- 1-( 3,4-methylenedioxyphenyl )-2 -butanamine 229 N-methyl- 1-( 3,4-methylenedioxyphenyl )-3 -butanamine 233 N-methyl-bis(trifluoroacetamide)...
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Color Atlas of Pharmacology (Part 17): Drugs Acting on Motor Systems

Color Atlas of Pharmacology (Part 17): Drugs Acting on Motor Systems
... terms and conditions of license Drugs Acting on Motor Systems Acetylcholine Succinylcholine Depolarization ACh Depolarization Succinylcholine Propagation of action potential (AP) Contraction 187 ... depend on hepatic or renal elimination Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license Drugs Acting on Motor Systems ... antagonist A Antiparkinsonian drugs Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 190 Drugs Acting on Motor Systems Antiepileptics...
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Color Atlas of Pharmacology (Part 18): Drugs for the Suppression of Pain

Color Atlas of Pharmacology (Part 18): Drugs for the Suppression of Pain
... the duration of the effect depends on the rate of enzyme resynthesis Furthermore, salicylate may contribute to the effect ASA irritates the gastric mucosa (direct acid effect and inhibition of ... secretion PG promote the production of gastric mucus and reduce the formation of gastric acid (p 160) Menstruation PGF2! is believed to be responsible for the ischemic necrosis of the endometrium ... inhibit both isozymes The search for COX-2-selective agents (Celecoxib, Rofecoxib) is intensifying because, in theory, these ought to be tolerated better Lüllmann, Color Atlas of Pharmacology © 2000...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 22)

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 22)
... shows mass spectra of the authentic cocaine, EME and BE after derivatization Setting up of cutoff values are very common in USA and Europe as a part of QC (quality control) and QA (quality assurance) ... Significance and problems of doping tests and toxin analysis Nipponrinsho 57:361–363 (in Japanese) 10) Sander R, Ryser MA, Lamoreaux TC et al (1985) An epidemic of cocaine associated deaths in Utah ... and death In addition, the ratios of cocaine to BE in blood and in the brain, and the brain-to-blood ratios of cocaine and BE were compared with those described in literature [11]; such comparison...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 23)

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 23)
... concentration in the horizontal axis and peak area ratio of pentazocine to IS in the vertical axis The peak area ratio of a test specimen is applied to the calibration curve to obtain its pentazocine ... bring its pH to about A 10-mL volume of ethanol and 10 mL distilled water are passed through a Sep-Pak C18 cartridge using a 10-mL volume glass syringe to activate the cartridge at a flow rate ... (17) 285 (9) Poisoning case, and toxic and fatal concentrations A 17-year-old female [11] ingested about 100 tablets of pentazocine (total amount estimated, 2.5 g) and fell into unconsciousness...
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Color Atlas of Pharmacology (Part 20): General Anesthetic Drugs

Color Atlas of Pharmacology (Part 20): General Anesthetic Drugs
... Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 218 General Anesthetic Drugs Inhalational Anesthetics The mechanism of action of ... structural relative of isoflurane, but has low lipophilicity that permits rapid induction and recovery as well as good control of anesthetic depth Lüllmann, Color Atlas of Pharmacology © 2000 ... of distribution A Termination of drug effect by redistribution Sodium thiopental Sodium methohexital Ketamine Propofol Etomidate Midazolam B Intravenous anesthetics Lüllmann, Color Atlas of Pharmacology...
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