Mobility is a key predictor of change in well being among older adults who experience falls evidence from the vancouver falls prevention clinic cohort

Mobility is a key predictor of change in well being among older adults who experience falls evidence from the vancouver falls prevention clinic cohort

Mobility is a key predictor of change in well being among older adults who experience falls  evidence from the vancouver falls prevention clinic cohort
... the data ACCEPTED MANUSCRIPT Mobility predicts wellbeing among older fallers Mobility is a key predictor of changes in wellbeing among older fallers: Evidence from the Vancouver Falls Prevention ... MANUSCRIPT Mobility predicts wellbeing among older fallers We conducted a longitudinal analysis of data from a 12-month prospective cohort study at the Vancouver 86 Falls Prevention Clinic (www.fallclinic.com) ... adults. [2] Wellbeing and quality of life are used 55 interchangeable here and are distinct from health related quality of life because they are not focused on 56 health alone Many health care issues among...
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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"

Báo cáo y học:
... study is a prospective clinical investigation of the prognostic value of circulating Ang-2 as a biomarker in critically ill patients The results are that: critically ill patients are characterised ... be statistically significant at a 10% level in the univariate analysis and subjected to multivariate Cox regression analysis: lactate, APACHE II score, SOFA score and circulating Ang-2 (Table ... al Conclusion In summary, a marked imbalance of the Ang/Tie system in favour of circulating Ang-2 is correlated with severity of illness and tissue hypoxia High Ang-2 is probably a powerful independent...
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Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours pot

Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours pot
... years has led us to consider again this point: can the succession of short hypoxia and reoxygenation phases, typical of intermittent hypoxia, also stabilize HIF- 1a and activate HIF-1? In the absence ... hypoxia in cancer S Toffoli and C Michiels Fig Effects of intermittent hypoxia and chronic hypoxia on HIF- 1a stabilization and HIF-1 target gene transcription transient hypoxia, extracellular signal-related ... or intermittent hypoxia are different Figure shows a brief comparison of HIF- 1a stabilization and HIF-1 activation under intermittent hypoxia and chronic hypoxia Tumour resistance induced by intermittent...
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Báo cáo khoa học: Myocyte enhancer factor 2 (MEF2) is a key modulator of the expression of the prothoracicotropic hormone gene in the silkworm, Bombyx mori ppt

Báo cáo khoa học: Myocyte enhancer factor 2 (MEF2) is a key modulator of the expression of the prothoracicotropic hormone gene in the silkworm, Bombyx mori ppt
... multicellular organisms [15] There are four isoforms (A D) of mammalian MEF2, and they have high homology within the 56-amino-acid MADS box at their N-termini and within an adjacent 29 -amino-acid region ... as the MEF2 domain The MADS box is essential for DNA binding and dimerization, and the MEF2 domain plays an important role in DNA binding affinity as well as an indirect role in dimerization The ... converted to grayscale and inverted into black and white images An area adjacent to the area of interest (A) and an area from an image lacking a specimen (N) were scanned as the background signals When...
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Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx

Báo cáo sinh học:
... primary blasts Haematologica 2008, 93:662-669 34 Sharma SV, Haber DA, Settleman J: Cell < /b> line-based platforms to < /b> evaluate the < /b> therapeutic efficacy of < /b> candidate anticancer agents Nat Rev Cancer < /b> ... Gautschi O, Mack PC, Davies AM, Lara PN, Gandara DR: Aurora < /b> kinase inhibitors: a < /b> new class of < /b> targeted drugs in < /b> cancer < /b> Clin Lung Cancer < /b> 2006, 8:93-98 Page 10 of < /b> 10 37 Mazzino A,< /b> Muratore-Ginanneschi ... frequencies of < /b> polyploidy Conveniently, it is < /b> standard clinical practice to < /b> perform karyotyping on hematological < /b> cancer < /b> cells and chromosome < /b> number < /b> can serve as an attractive resistance marker...
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o cáo hóa học:" High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" ppt

o cáo hóa học:
... inhibitors Conveniently, it is < /b> standard clinical practice to < /b> perform karyotyping on hematological < /b> cancer < /b> cells and chromosome < /b> number < /b> can serve as a < /b> resistance marker for patient response < /b> to < /b> GSK1070916 ... percentage of < /b> polyploidy in < /b> cell < /b> subpopulations For instance, the < /b> karyotype data for the < /b> TANOUE cell < /b> line has a < /b> chromosome < /b> modal number < /b> of < /b> 48 for the < /b> primary population of < /b> cells, but also 12% of < /b> the < /b> cell < /b> ... which potentially contributes to < /b> the < /b> sensitivity observed in < /b> these cell < /b> lines < /b> Comparison of < /b> the < /b> two response < /b> phenotypes for modal chromosome < /b> number,< /b> using a < /b> chromosome < /b> count of < /b> (3n) as the < /b> cutoff,...
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Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx

Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx
... motifs that are characteristic of RNA-binding proteins, and an alanine-rich carboxy-terminal sequence that could be involved in protein–protein interactions Interestingly, this alanine-rich sequence, ... Gld2 Rbm9 interaction (Fig 2B) However, the RRM-containing central domain of hRbm9 (amino acids 48–269) and amino acids 269–350 of hRbm9 are not able to mediate the binding These data suggest that ... XGld2 to specific mRNA The molecular mechanism underlying XRbm9-dependent translational activation is unclear and awaits further investigations The subcellular localization of mammalian Rbm9 is...
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Báo cáo khoa học: Cellulose crystallinity – a key predictor of the enzymatic hydrolysis rate pptx

Báo cáo khoa học: Cellulose crystallinity – a key predictor of the enzymatic hydrolysis rate pptx
... impact on the crystallinity of untreated Avicel Multivariate statistical analysis of X-ray data The CrI of cellulose samples was also calculated by quantifying the contribution of amorphous cellulose ... such dramatic drops in the rate Constant crystallinity and decreased rates indicate surface changes on cellulose that start rapidly after the beginning of hydrolysis Factors other than crystallinity ... intermediate degrees of conversion, the rate of the reaction decreases dramatically, and the final part of cellulose hydrolysis requires an inordinate fraction of the overall total reaction time...
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Báo cáo y học: "Sepsis is a major determinant of outcome in critically ill HIV/AIDS patients." pdf

Báo cáo y học:
... survival of critically ill HIV/AIDS patients In this study, we prospectively followed up HIV/AIDS critically ill patients to evaluate the key factors related to outcome, with emphasis on impact of ... sepsis is the main risk factor for hospital mortality in a cohort of HIV/AIDS critically ill patients Sepsis-related mortality was increased in both shortand longer-term follow-up Indeed, sepsis ... development of organ dysfunctions was analyzed as a possible contribution to hospital mortality In our study, cardiovascular and respiratory dysfunctions increased the hazards of death, especially in...
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Báo cáo y học: "he miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition" pdf

Báo cáo y học:
... GJ, Hammond SM: A microRNA polycistron as a potential human oncogene Nature 2005, 435:828-833 Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y, ... HAS2 -A HDAC4 -A HDAC4-B HDAC4-C HDAC4-D HIF1 -A HIF 1A- B IRF1 -A KHDRBS1 -A KHDRBS1-B KPNA2 -A MAP3K8 -A MAP3K8-B MAPK9 -A MYCN -A MYCN-B NCOA3 -A NCOA3-B NCOA3-C NCOA3-D NR 4A3 -A NR 4A3 -B NR 4A3 -C PCAF -A ... additional data are available with the online version of this paper Additional data file is a table listing the G1/S associated mRNAs predicted to be targets of miR-17-5p Additional data file is a figure...
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báo cáo sinh học:" Is satisfaction a direct predictor of nursing turnover? Modelling the relationship between satisfaction, expressed intention and behaviour in a longitudinal cohort study" pdf

báo cáo sinh học:
... unable to say at this stage (26 – 39%) Statistical modelling The final stage of analysis focuses on the modelling of intentions and working as a nurse The relationships between intentions expressed ... Figure Path model of job satisfaction, future intentions and nursing at 18 months and years Path model of job satisfaction, future intentions and nursing at 18 months and years Odds Ratios are shown ... job satisfaction data at and 18 months using principal component analysis with varimax rotation and Kaiser normalization to ascertain whether the eight factors (Care, Staffing, Development, Relationships,...
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Báo cáo y học: " Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury" ppt

Báo cáo y học:
... that both the absolute value of respiratory system compliance on day and the decrease in respiratory system compliance between days and of mechanical ventilation for ALI are associated with increased ... adjusted odds ratio of death for selected variables on day 1, day and the change in each variable between day and day Day Δ Day Day Day Variable OR* 95% CI P OR* 95% CI P OR* 95% CI P PaO2/FiO2 1.02 ... studies have reported an average duration of mechanical ventilation in ALI between and 16 days, suggesting that a large proportion of patients with ALI are alive and mechanically ventilated days after...
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Báo cáo khoa học: Insect cytokine, growth-blocking peptide, is a primary regulator of melanin-synthesis enzymes in armyworm larval cuticle pptx

Báo cáo khoa học: Insect cytokine, growth-blocking peptide, is a primary regulator of melanin-synthesis enzymes in armyworm larval cuticle pptx
... (L5D2), day last instar (L6D0), and day last instar (L6D1) larvae (Inset) DDC activity in integuments from the same larval stages a* , Significantly different from TH activity of L5D2 larval dorsal integument ... counter (Aloka LSC5100, Tokyo, Japan) Cloning and sequence analysis of TH cDNA Total RNA was isolated from integuments of day last instar larvae using TRIzol reagent (Gibco-BRL) according to the manufacturer’s ... (5¢-CAGCTGCCCAGAAGAACCGCGAGA TG-3¢, +11 to +36; and 5¢-GAACTCCACGGTGAACC AGT-3¢, +1286 to +1305 bp), DDC-specific primer pair (5¢-ATGGAGGCCGGAGATTTCAAAG-3¢, +1 to +22 bp; and 5¢-ACGGGCTTTAAGTATTTCATCAGGC-3¢,...
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Báo cáo khoa học: Ets-1/ Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells pdf

Báo cáo khoa học: Ets-1/ Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells pdf
... b-actin cDNA was also amplified using primers b-actin F (sense) (5¢-AGAAAATCTGGC ACCACACC-3¢) and b-actin R (antisense) (5¢-TAGCACAGCCTGGATAGCAA-3¢), and served as the internal control Melting-curve ... against Ets-1 raised against its N-terminal region and an antibody against Elk-1 raised against phosphorylated Ser383 present at the C-terminus of this protein Preincubation of nuclear proteins ... of acetyl-lleucyl-l-argininal, inhibitor of dipeptidyl aminopeptidase III by bacteria J Antibiot (Tokyo) 37, 680–681 Hazato T, Inagaki-Shimamura M, Katayama T & Yamamoto T (1982) Separation and...
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Báo cáo khoa học: A pH-dependent conformational change in EspA, a component of the Escherichia coli O157:H7 type III secretion system potx

Báo cáo khoa học: A pH-dependent conformational change in EspA, a component of the Escherichia coli O157:H7 type III secretion system potx
... Kurokawa K, Ishii K, Yokoyama K, Han CG, Ohtsubo E, Nakayama K, Murata T, Tanaka M, Tobe T, Iida T, Takami H, Honda T, Sasakawa C, Ogasawara N, Yasunaga T, Kuhara S, Shiba T, Hattori M & Shinagawa ... species, then a plot of the natural logarithm of the protein absorption at 280 nm [ln (A2 80)] vs the square of the radial distance (r2) shows a linear T Kato et al correlation between ln (A2 80) and ... even at pH 2.0 However, ANS binding experiments indicate that a conformational change occurred upon decreasing pH The characteristics of this conformational change are consistent with the formation...
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