Smooth muscle

Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: a coupled oscillator-based mechanism in smooth muscle ppt

Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: a coupled oscillator-based mechanism in smooth muscle ppt
... by Ca2+ waves, a significant form of signaling in living organisms [20–22] Ca2+ waves are considered to be generated by the release of Ca2+ from a dominant store, triggering Ca2+- induced Ca2+ ... 32 Lakatta EG, Vinogradova T, Lyashkov A, Sirenko S, Zhu W, Ruknudin A & Maltsev VA (2006) The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation ... coupling, in that store-generated changes in [Ca2+] c are required to activate inward membrane current, with the resulting membrane depolarization activating or advancing the phase of other Ca2+stores...
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Tài liệu Báo cáo khoa học: Thermal unfolding of smooth muscle and nonmuscle tropomyosin a-homodimers with alternatively spliced exons docx

Tài liệu Báo cáo khoa học: Thermal unfolding of smooth muscle and nonmuscle tropomyosin a-homodimers with alternatively spliced exons docx
... structure of smooth muscle a-Tm and the two fibroblast isoforms Tm5a and Tm5b with constitutive exons are shown in white, smooth muscle exons in light grey, and nonmuscle exons in dark grey found in nonmuscle ... comparison of Tm5a with smTm allows study of the effects of replacement of muscle exons 1a and 2a by nonmuscle exon 1b, and comparison of Tm5a with Tm5b allows the effects of exchange of exon to ... Studies of thermal unfolding of Tm may provide valuable information on the structure of Tm both free Thermal unfolding of nonmuscle tropomyosin in solution and bound to actin Thermal unfolding of...
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Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx

Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx
... preponderant role of p38 in the regulation of gene expression at the level of mRNA stability The p38 MAP kinase is now known to stabilize a wide range of mRNAs including those encoding TNF-a, interferon ... organization of the actin cytoskeleton and the superinduction of the CTGF/ CCN2 gene Rho-like GTPases play a pivotal role in orchestrating changes in the actin cytoskeleton in response to various ... activation of the CTGF/CCN2 gene although RhoA GTPase- independent required an intact cytoskeleton, and, at least in part, the upstream activation of PtdIns 3 -kinase Inhibition of PtdIns 3 -kinase reduced...
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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf

Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
... cyclin D1 gene promoter We studied the mechanism(s) underlying the inhibition of cyclin D1 gene expression by EPA and DHA by examining the effects of n-3 and n-6 PUFAs incorporation on cyclin D1 promoter ... control of SMC proliferation 4466 S Bousserouel et al (Eur J Biochem 271) Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAs Induction of cyclin D1 is one of the ... concentrations of cyclin D1, Rb and Egr-1, in order to determine how the incorporation of EPA and DHA modulate SMC proliferation This article describes the differing effects of n-3 and n-6 PUFAs...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx

Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives ... amphiphilic structure of the polar carboxyl moiety and the hydrophobic isoprene moiety The enhancing effect of TS on LPS/IFN -induced NO production was inhibited by the coexistence of a-T, TA and TN ... the VSMC, but TS was not hydrolyzed to a-T and succinic acid [32] Accordingly, the enhancement of LPS/IFN -induced NO production is attained by TS itself rather than a derivative TS enhanced LPS-dependent...
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Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx

Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx
... mechanisms of smooth muscle cell loss in vascular amyloidosis Our studies show that homocysteine, a risk factor for certain cardiovascular diseases, can increase susceptibility of VSMC to Ab toxicity ... solution [48] The aggregation of Ab is thought to be significant in Alzheimer pathogenesis since it correlates with neuronal toxicity in vitro [41–43] This may apply to myotoxicity as Wisniewski ... peptides, this toxicity is exacerbated This effect of homocysteine and Ab has also been shown in primary cortical neurons [66] and in neuroblastoma cells [67] This indicates that homocysteine may induce...
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Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt

Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt
... preparation Of particular importance is the finding that exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38 In other words, the presence of CD38 is mandatory for the ... facilitates the spontaneous release of ATP, probably because of in ux of cADPR through CD38 and subsequent activation of intracellular ryanodine-sensitive cADPR receptors The EFS-evoked release of ATP, ... significant increase in the spontaneous overflow of ATP in CD38+ ⁄ + mice In CD38) ⁄ ) mice, spontaneous overflow of ATP was not increased in the presence of cADPR (P > 0.05) LU, luminescence units:...
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Báo cáo khoa học: Heme oxygenase-1 ⁄p21WAF1 mediates peroxisome proliferator-activated receptor-c signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells pot

Báo cáo khoa học: Heme oxygenase-1 ⁄p21WAF1 mediates peroxisome proliferator-activated receptor-c signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells pot
... PASMC proliferation Proliferation of PASMCs is a hallmark of pathogenesis of pulmonary hypertension [1,4] However, the mechanisms responsible for inhibition of PASMC proliferation by activation of ... Role of p21WAF1 in HO-1-mediated suppression of proliferation of PASMCs Recent studies have revealed that an antiproliferative effect of HO-1 on non-PASMC pulmonary vascular smooth muscle cells ... stimulates HO-1 expression in pulmonary artery smooth muscle cells (PASMCs) (vascular smooth muscle cells showing some differences from systemic vascular smooth muscle cells) If so, whether and how...
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Báo cáo khoa học: Endogenous mono-ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of c-fos expression potx

Báo cáo khoa học: Endogenous mono-ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of c-fos expression potx
... MAP kinase, Rho mediates growth factor-dependent activation of c-fos via the serum response factor (SRF) [30] Protein kinase C-related kinase (PRK1), also termed protein kinase N (PKN), and PRK2 ... the proliferation of human and rat vascular smooth- muscle cells Biochem J 283, 403–408 Saward, L & Zahradka, P (1997) Coronary artery smooth muscle in culture: migration of heterogeneous cell ... not connected to SMC migration MIBG prevents induction of c-fos gene expression by mitogens Increased c-fos gene activity is a hallmark of mitogen stimulation, and RT-PCR of total RNA was therefore...
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Báo cáo Y học: Cloning and characterization of novel snake venom proteins that block smooth muscle contraction pptx

Báo cáo Y học: Cloning and characterization of novel snake venom proteins that block smooth muscle contraction pptx
... hydrochloride, and mM EDTA in a volume of 0.5 mL Three microliters of 4-vinylpyridine were then added, and alkylation was allowed to proceed for h at room temperature The S-pyridylethylated proteins ... and cloning of tigrin and ablomin During the isolation process of a prothrombin activator from the Duvernoy’s gland of Yamakagashi snake (R tigrinus tigrinus), we identified a large quantity of ... sequences of triflin and latisemin are homologous to that of ablomin (83.7 and 61.5%, respectively) Like ablomin, these proteins were capable of blocking contraction of the artery induced by high K+ (Fig...
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Báo cáo khoa học: Synergistic co-operation of signal transducer and activator of transcription 5B with activator protein 1 in angiotensin II-induced angiotensinogen gene activation in vascular smooth muscle cells potx

Báo cáo khoa học: Synergistic co-operation of signal transducer and activator of transcription 5B with activator protein 1 in angiotensin II-induced angiotensinogen gene activation in vascular smooth muscle cells potx
... Janus kinase ⁄ signal transducer and activator of transcription signaling pathway mediate the regulation of systemic and tissue localized renin -angiotensin system Mol Endocrinol 18 , 10 33 10 41 11 Xu ... studies indicate that transcription activation by STATs requires activated AP -1 [11 13 ] AP -1 is a complex composed of the Fos and Jun proteins [14 16 ] In general, Fos and Jun family proteins function ... role of angiotensinogen Endocr Rev 18 , 662–677 Mascareno E, Dhar M & Siddiqui MA (19 98) Signal transduction and activator of transcription (STAT) protein- dependent activation of angiotensinogen...
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báo cáo hóa học:" Birth weight and characteristics of endothelial and smooth muscle cell cultures from human umbilical cord vessels" docx

báo cáo hóa học:
... vascular cell types obtained from human umbilical cords (UCs) Cell proliferation kinetics of vascular cell types obtained from human umbilical cords (UCs) Human umbilical artery and vein endothelial ... of exponentially growing and confluent human umbilical artery endothelial cell cultures Proliferation fraction of exponentially growing and confluent human umbilical artery endothelial cell cultures ... (2.8 and 2.1%, respectively) Discussion Simultaneous growth of endothelial and smooth muscle cells from the UC arteries and veins of children born at term showed that artery endothelial cell cultures...
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báo cáo hóa học: " Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular smooth muscle cells" docx

báo cáo hóa học:
... parenchyma, another prominent site of extracellular Aβ deposition is within and along primarily small and medium-sized arteries and arterioles of the cerebral cortex and leptomeninges and in the cerebral ... neuroinflammation and cellular pathology within the cerebral vessel wall, we determined the effects of dexamethasone and two nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen and indomethacin, ... of smooth muscle cell α actin, a consequence that was essentially prevented in the presence of dexamethasone (Figure 6) In contrast, neither indomethacin nor ibuprofen was capable of preventing...
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Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability doc

Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability doc
... Jiang et al., Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability Journal of Biomedical Science 2010, 17:6 Page 12 of 12 ... the rate of cell migration, but to a lesser extent (0.417 ± 0.01 of the control cells) The motility of D1234 transfected cells (0.65 ± 0.028) was higher than the cells transfected with all other ... 1-d,e) Effect of phosphomimetic mutation of CaD on the motility of A7r5 cells To determine the effect of phosphomimetic mutation of CaD on the motility of A7r5 cells, we have performed Boyden chamber...
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Báo cáo y học: "Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells" doc

Báo cáo y học:
... SOCs in pulmonary artery myocytes is regulated by PKG and PKA The guanylate cyclase-cyclic GMP-protein kinase G signaling pathway plays a pivotal role in several physiological processes including ... surrounding tissue and cut into mm segments Preparation of isolated pulmonary artery myocytes Pulmonary artery smooth muscle cells (PASMCs) from rat intralobar pulmonary arteries were enzymatically ... molecules are involved in these protein kinase pathways Conclusions In summary, this study presents evidence that protein kinases play an important role in regulating SOCs in smooth muscles derived...
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