MOLECULAR PHARMACOLOGY, REGULATION AND FUNCTION OF MAMMALIAN MELATONIN

Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line

Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line
... the siRNA sequence that is most effective in knocking down DLEC1 in HCT116 cell line We then knocked down DLEC1 in the HCT116 cell line using this siRNA 72 hours after the transfection, the cells ... that it was a candidate tumor suppressor gene The over-expression of DLEC1 in hepatocellular carcinoma (HCC) cell lines such as HepG2 and SK-Hep-1 resulted in the inhibition of cell proliferation, ... reduction in cell size and G1 cell cycle arrest (Qiu et al., 2008) In this study, we further validated the tumor suppressing properties of DLEC1 in the HCT116 cell line The cells were subjected to DLEC1...
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Báo cáo y học: "Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective" pdf

Báo cáo y học:
... [GuillainBarre syndrome: a study of 13 children] An Esp Pediatr 1993, 39:513-516 79 Horiuchi I, Kawano Y, Yamasaki K, Matsuo H, Minohara M, Nakamura T, Hashiguchi H, Ohyagi Y, Yamada T, Kira J: ... deficiency diseases II Serum IgE concentration of patients with acquired hypogammaglobulinemia, thymoma and hypogammaglobulinemia, myotonic dystrophy, intestinal lymphangiectasia and Wiskott-Aldrich ... order of frequency Pate et al Clinical and Molecular Allergy 2010, 8:3 http://www.clinicalmolecularallergy.com/content/8/1/3 indicate that IgE antibody may play a protective role in some parasitic,...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis

The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression The pRb Cell Cycle Control Pathway: Components and the Cancer Connection The retinoblastoma protein, ... over-expression of D-type cyclins, mutations rendering Cdk4 The Retinoblastoma Gene Family 185 Fig The p16INK4A -pRb and the p19ARF -p53 pathway involved in cell cycle progression and tumorigenesis Components ... will be used The Retinoblastoma Gene Family 187 The Retinoblastoma Gene Family 4.1 Rb Gene Family Members The retinoblastoma gene family comprises, besides Rb, the structurally and functionally...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... significance of histone H4 lysine 16 acetylation Active chromatin and DNase I hypersensitive sites Basic features of chromatin structure and the influence of transcription Nucleosomes are the basic building ... permissive for transcription It is generally accepted that active genes lie within broad active chromatin domains that carry a variety of modifications associated with active chromatin [18–23] Active ... lysines leads to neutralization of the positively charged nitrogen atoms that mediate contacts between histone tails and DNA, ren- Active chromatin and DNase I hypersensitive sites dering individual...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... PDZ -domain- containing (FRMPD2) [8] and Ras guanine exchange factor (RasGEF) veryKIND (v-KIND, or kinase noncatalytic C-lobe domain containing 1) [9] The KIND domain in these proteins is localized to the ... determined the structural and functional properties of the protein protein interaction between v-KIND and MAP2 We defined the binding core regions for the v-KIND–MAP2 interaction and showed that the ... both KIND1 and KIND2; DRasN, deletion of RasN; DGEF, deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 domain (B) KIND2 domain anchors v-KIND to dendrites Flag-tagged v-KIND, DKIND1, DKIND2,...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc

Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
... investigate the physiological relevance of Noxo1c expression in the testis, we examined expression of Nox1 and Noxa1 by PCR analysis and found a small but significant amount of the Nox1 and Noxa1 mRNAs ... al Expression and function of Noxo1c A B C Fig Alternative splice forms of human Noxo1 (A) The genomic organization of human NOXO1 gene Translated sequences are shown as black boxes, and untranslated ... extent of membrane localization of Noxo1b and Noxo1c The intensities of immunoreactive bands for HA-Noxo1b and HA-Noxo1c in (B) were quantified using a LAS -10 00plus (Fuji film) image analyzer and...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx

Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
... roles of plant APs References Davies, D.R (1990) The structure and function of the aspartic proteinases Annu Rev Biophys Biophys Chem 19, 189–215 Dunn, B.M (2002) Structure and mechanism of the ... prosegment and total or partial removal of the internal Ó FEBS 2004 Plant aspartic proteinases (Eur J Biochem 271) 2069 Fig Ribbon representation of the crystal structures of cardosin A (A) and prophytepsin ... representation of the structure of the PSI domain of barley prophytepsin [25] (N-terminal domain, blue; C-terminal domain, red) (C) Model structure of the PSI domain of cardosin A based on the crystal structure...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... domain of each subunit contributes to the formation of the hydrophilic pore ACh binding protein has structural and functional homology to the extracellular ligand binding domain of the nAChR, and ... development of selective drugs is the identification and pharmacological characterization of the various receptor subtypes, and the determination of their precise subunit composition and physiological function( s) ... targets the a/d interface of the mammalian muscle nAChR and is the only ligand selective for the Torpedo a/d interface [33] (Fig 2A) However, information on the activity of EI at neuronal subtypes...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf

Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... with the structure of the longer isoform CfAFP-501 using the main chain of residues Thr23fiAsn90 in isoform 337 and residues Thr54fiMet121 in CfAFP-501 (B) Overlap of isoforms 337 and 501 using the ... Ser12fiThr70 in the structure alignment (B) Overlap of the X-ray structure with the 30 °C NMR structure using the main chain of residues Ser12fiThr70 in the structure alignment (C) Overlap of X-ray structure ... in TH activity of CfAFP-501 Dynamics of insect AFPs To determine whether changes in temperature cause changes in the structure of the insect AFPs and to further characterize the TXT face of these...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt

Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
... C An et al Manduca sexta Spatzle ¨ Introduction A prominent feature of the innate immune systems of insects is the activation of serine proteinase cascade pathways in hemolymph, which function ... gene In the clade including Spatzle- 1, the branch lengths are noticeably longer and ¨ the bootstrap values are lower than in the other clades containing Spatzle- 2 to Spatzle- 6, indicating a lower ... cleavage of proSpatzle- 1A after ¨ incubation with the M sexta clip-domain serine proteinases HP6 or proPO-activating proteinase-1 (data A not shown) In the absence of b-mercaptoethanol, Spatzle- C108...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf

Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... (2 010 ) 2 611 –2627 ª 2 010 The Authors Journal compilation ª 2 010 FEBS A B Mantsyzov et al 10 11 12 13 14 15 16 17 domain of release factor eRF1 functions in stop codon recognition RNA 6, 12 36 12 47 ... = 10 8 (s )1) Dyy = 10 8 (s )1) Dzz = 10 8 (s )1) s1 = (4Dxx + Dyy + Dzz) )1 (ns) s2 = (Dxx + 4Dyy + Dzz) )1 (ns) s3 = (Dxx + Dyy + 4Dzz) )1 (ns) 0 .10 2 0 .12 5 0 .14 0 14 .86 13 .48 12 . 71 0 .10 1 0 .12 8 0 .13 9 14 .90 ... polypeptide chain factors, eukaryotic class polypeptide chain release factor (eRF1) and eukaryotic class polypeptide chain release factor (eRF3) The major functions of eRF1 include recognition of each of...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc

Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc
... Alphaproteobacteria Proteobacteria, Alphaproteobacteria Proteobacteria, Alphaproteobacteria Proteobacteria, Alphaproteobacteria Proteobacteria, Betaproteobacteria Proteobacteria, Betaproteobacteria Proteobacteria, ... Betaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria Proteobacteria, Gammaproteobacteria 2 2 2 2 ... Chromohalobacter salexigens DSM3034 Acinetobacter sp (strain ADP1) Pseudomonas fluorescens Pf5 ATCC BAA-477 Actinobacteria, Actinobacteria Proteobacteria, Alphaproteobacteria Proteobacteria, Alphaproteobacteria...
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Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx

Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx
... FEBS 1849 Biology and chemistry of b-secretase (BACE-1) C E Hunt and A J Turner BACE-1 promoter, and several studies have reported the upregulation of BACE-1 mRNA both in vitro and in vivo following ... Biology and chemistry of b-secretase (BACE-1) C E Hunt and A J Turner A B Fig Processing of APP to form Ab peptides (A) Schematic diagram of the alternative processing pathways of APP The ... Modulation of protein–protein interactions affecting localization and ⁄ or activity Modulation of lipid environment of the enzyme Immunization with BACE-1 Modulation of miRNA regulation of BACE-1...
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Báo cáo khoa học: Synthesis and function of ribosomal proteins – fading models and new perspectives pptx

Báo cáo khoa học: Synthesis and function of ribosomal proteins – fading models and new perspectives pptx
... absence of ribosomal RNA synthesis, the ribosomal proteins of HeLa cells are synthesized normally and degraded rapidly J Mol Biol 115, 31 5–3 33 90 Komili S, Farny NG, Roth FP & Silver PA (2007) Functional ... sclerosis complex (TSC) 1– TSC2, and the mammalian target of rapamycin (mTOR) C1 complex (composed of raptor, mLst8, and mTOR) The role of TSC1–TSC2 in the translation of TOP mRNAs has been recently ... models for RP deficiency are summarized in Table Conclusions In the last few years, the study of the synthesis and function of RPs has both expanded our knowledge FEBS Journal 276 (2009) 319 9–3 210...
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