Rapid Clinical Pharmacology

CLINICAL PHARMACOLOGY 2003 (PART 25B)

CLINICAL PHARMACOLOGY 2003 (PART 25B)
... 17:151-183 Maxwell S 1999 Emergency management of acute myocardial infarction British Journal of Clinical Pharmacology 48: 284-298 Manhapra A, Borzak S 2000 Treatment possibilities for unstable angina ... receiving ramipril mg x 2/d, started 3-10 days after a myocardial infarction in 2006 patients with only clinical signs of heart failure.28 Indeed, in addition to these drugs, most patients should receive ... Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure Lancet 342: 821-828 Swedberg K P et al 1992 Effects of the early...
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CLINICAL PHARMACOLOGY 2003 (PART 28)

CLINICAL PHARMACOLOGY 2003 (PART 28)
... in removing salt and water that any drug can achieve is related to its site of action, and it is clinically appropriate to rank diuretics according to their natriuretic capacity, as set out below ... controlled conditions and should not be taken to represent the average fractional sodium loss during clinical use High efficacy Frusemide (furosemide) and the other (loop) diuretics can cause up to ... say, days a week • As an antihypertensive 1.25-2.5 mg is given daily; in the absence of a diuresis clinically important potassium depletion is uncommon, 533 26 K I D N E Y AND G E N I TO U R I N...
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CLINICAL PHARMACOLOGY 2003 (PART 29)

CLINICAL PHARMACOLOGY 2003 (PART 29)
... syndrome similar to vitamin K deficiency.3 Bishydroxycoumarin (dicoumarol) was introduced into clinical practice as an anticoagulant in the 1940s and other structurally related vitamin K antagonists ... due to intracranial haemorrhage Management of bleeding or over-anticoagulation is guided by the clinical state and the INR:7 • Haemorrhage threatening life or major organs In addition to blood ... 1285-1288 British Society for Haematology 1990 Guidelines on oral anticoagulants, 2nd edn Journal of Clinical Pathology 43: 177-183 (Reproduced with permission) A study of 261 patients who received...
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CLINICAL PHARMACOLOGY 2003 (PART 30)

CLINICAL PHARMACOLOGY 2003 (PART 30)
... These interactions can be clinically important Ingestion should be separated by hours Ascorbic acid increases absorption (see above) but its use (200 mg/day) is not clinically important in routine ... Medicine 341:1509-1519 Castle W B 1966 Treatment of pernicious anaemia: historical aspects Clinical Pharmacology and Therapeutics 7: 347 Ferner R E et al 1989 Drugs in donated blood Lancet 2: ... enterohepatic circulation which can be interrupted by intestinal disease and hastens the onset of clinical deficiency), and is excreted via the kidney Body stores amount to about mg (mainly in the...
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CLINICAL PHARMACOLOGY 2003 (PART 31)

CLINICAL PHARMACOLOGY 2003 (PART 31)
... lymphoblastic leukaemia Other cytotoxic agents in clinical use include procarbazine, dacarbazine, hydroxyurea (hydroxycarbamide) Chemotherapy in clinical practice DRUG USE ANDTUMOUR CELL KINETICS ... specific for chronic granulocytic leukaemia; clinical trials support its efficacy in this disease 618 • Agents that promote apoptosis are being developed for clinical use Chemoprevention of cancer ... confined to one phase of the cell cycle, e.g antimetabolite drugs) A list of drugs currently in clinical use appears in Table 30.2 Table 30.3 provides detail of toxicity of individual agents The...
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CLINICAL PHARMACOLOGY 2003 (PART 32)

CLINICAL PHARMACOLOGY 2003 (PART 32)
... ulcerhealing course is weeks Cimetidine Cimetidine was the first H2 receptor antagonist to be used in clinical practice It is rapidly absorbed from the gastrointestinal tract and its plasma t1/2 is ... the final common pathway for acid production Omeprazole was the first preparation to be used in clinical practice and esomeprazole, lansoprazole, pantoprazole and rabeprazole were subsequently ... infections as a result of prolonged hypochlorhydria There is as yet no real evidence for these being a clinical problem Proton pump inhibitors are widely used and possible adverse effects from very long...
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CLINICAL PHARMACOLOGY 2003 (PART 33)

CLINICAL PHARMACOLOGY 2003 (PART 33)
... mineral spring water, and for horse racing 640 the treatment of hepatic encephalopathy (see Chapter 33) Osmotic laxatives are frequently used to clear the colon for diagnostic procedures or surgery ... bacteria including Shigella and Salmonella spp, viruses including the Norwalk family, and parasites (particularly Giardia lamblia) have also been implicated Recognition that transmission is almost ... abdominal pain, although there is little objective evidence for their efficacy from controlled clinical trials The generation of evidence is complicated by the variable nature of IBS symptoms,...
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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 1) docx

Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 1) docx
... reading Clinical Pharmacology The world of clinical pharmacology has greatly changed since 1957 when I took up my pen, and I wish my successors well D R Laurence, Professor Emeritus of Pharmacology ... a good remedy sometimes to use nothing.' Hippocrates 460-355 B.C CLINICAL PHARMACOLOGY P N Bennett MD FRCP Reader in Clinical Pharmacology, University of Bath, and Consultant Physician, Royal ... special interest in pharmacology We try to make pharmacology understandable for those whose primary interests lie elsewhere but who recognise that they need some knowledge of pharmacology if they...
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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 35) doc

Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 35) doc
... not enough could be obtained to provide supplies for clinical trial In 1948 cortisone was made from bile acids in quantity sufficient for clinical trial, and the dramatic demonstration of its ... syndrome Lancet 357: 783-791 English J et al 1983 Diurnal variation in prednisolone kinetics Clinical Pharmacology and Therapeutics 33: 381 Freidy J F 1988 Reactions to contrast media and steroid ... the first clinical use of an adrenocortical steroid in inflammatory disease See also page 298 for an account by E C Kendall of the biochemical and pharmaceutical background to the clinical studies...
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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 36) doc

Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 36) doc
... and crystalline suspension, it is not expected that doctors or patients would vary the formulation prescribed The important thing is for the doctor to get to know well a range that will serve ... glucose uptake in the brain during episodes of hypoglycaemia that trigger a symptomatic and neuroendocrine response in patients with elevated levels of HbAlc (see Boyle et al 1995, in Guide to Further ... and other peripheral organs receive the same concentration INSULIN 35 This difference may have clinical importance and this is why some continous infusion pumps (see below) deliver insulin intraperitoneally...
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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 38) pptx

Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 38) pptx
... Lancet 345: 170-175 Relston S H 1992 Medical management of hypercalcaemia British Journal of Clinical Pharmacology 34:11-20 Seeman E 2002 Pathogenesis of bone fragility in women and men Lancet ... 25hydroxylation Advantages of alfacalcidol and dihydrotachysterol include a fast onset and short duration of clinical effect (days) which renders them suitable for rapid adjustment of plasma calcium, e.g in ... generally a plasma concentration of 3.0 mmol/1 (12 mg/100 ml) needs urgent treatment if there is also clinical evidence of toxicity (individual tolerance varies greatly) 2-3 days and continued at a...
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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 2) ppt

Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 2) ppt
... the pharmaceutical industry Principal sources of guidance 37 Ian Dodds-Smith A professor of clinical pharmacology who has made special studies of prescribing and patient information writes: 'What ... Ernst E, Thompson J 2001 Heavy metals in traditional Chinese medicines: a systematic review Clinical Pharmacology and Therapeutics 70: 497-504 Ferner R E 2000 Medication errors that have led to ... Erratic patient compliance with prescribed drug regimens: target for drug delivery I systems Clinical Pharmacology and Therapeutics 67: 331-334 Vickers A 2000 Complementary medicine British Medical...
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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 3) ppt

Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 3) ppt
... they not create dependence, (2) the patient does not increase the dose and create dependence, (3) they are not used as an unwitting source of supply to addicts To many such drugs special prescribing...
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Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 4) pptx

Tài liệu CLINICAL PHARMACOLOGY 2003 (PART 4) pptx
... Science, medicine and clinical pharmacology British Journal of Clinical Pharmacology 40:1-9 Breckenridge A1999 Clinical pharmacology and drug regulation British Journal of Clinical Pharmacology 47: ... Ethics and law in clinical pharmacology British Journal of Clinical Pharmacology 27: 715-722 Reidenberg M M 1999 Clinical pharmacology: the scientific basis of therapeutics Clinical Pharmacology and ... W 1990 Lancet 336: 1200) CLINICAL PHARMACOLOGY Grahame-Smith D G 1991 Clinical Pharmacology Roles and responsibilities in academic research British Journal of Clinical Pharmacology 32:151 Laurence...
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