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Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx
... half-time for binding to the Characterization of the binding of PCSK9 to intact cells Fig Nonlinear regression and Scatchard analyses of binding- inhibition data (A) Inhibition of [125I]TC-PCSK9 (2.5 ... binding to HepG2 cells To determine whether the kinetics of binding of PCSK9 to HepG2 cells can be described as a simple bimolecular reaction, the kinetics of [125I]TC-PCSK9 and [125I]TC-PCSK9-D374Y ... [125I]TC-PCSK9 binding by unlabeled wild -type PCSK9 (C) Inhibition of [125I]TCPCSK9-D374Y (1 lgÆmL)1) binding to HepG2 cells (9. 2 9. 8 · 105) by increasing concentrations of unlabeled PCSK9-D374Y Error...
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Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf
... Matteı et al ¨ Membrane targeting and pore formation by the T3SS Host membrane Translocon Needle A Bacterium B C D Translocators Fig Schematic diagram illustrating needle and translocon formation, ... formation of the Pop translocon on the eukaryotic membrane, toxins produced in the bacterial cytoplasm release their cognate chaperones and are injected through the translocon pore and into the target ... Structural analysis of a prototypical ATPase from the type III secretion system Nat Struct Mol Biol 14, 131–137 Membrane targeting and pore formation by the T3SS 38 Imada K, Minamino T, Tahara A &...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx

Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... seen in the putative T-box DNA-binding domain of t-bet, the STAT protein interaction domain, STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger ... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context of a longer peptide motif within a ... expression of these genes within humans and mice, of T-bet within Ginbuna crucian carp [27] and STAT6 in mandarin fish [28] have shown similar widespread expression In the case of STAT6, highest...
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Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx
... Roles of prostaglandin D2 in adipogenesis in vivo Y Fujitani et al indicate that overexpression of H-PGDS increases insulin sensitivity in vivo Adipocyte differentiation ex vivo Finally, we examined ... of WT mice Serum levels of triglyceride, glucose, leptin and insulin, and insulin sensitivity, in TG mice After weeks of normal or HF diet, serum levels of triglyceride, glucose, leptin and insulin ... ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide synthase-1, and hematopoietic prostaglandin D2 synthase and increased IgE-dependent prostaglandin D2...
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Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt
... (Y1 , Y2 , Y4 , Y5 and y6 ) that vary in their binding profiles and in their distribution in the central nervous system and periphery Y1 , Y2 and Y5 are the best characterized NPY receptors, and the ... debatable whether the effect of Y1 results only from local production of NPY Thus, further studies are needed to fully assess the direct role of NPY and Y1 in bone remodeling The NPY Y2 Y1 crosstalk ... injury Fat tissue Hypothalamus NPY Leptin Y2 Circulating NPY Sympathic nervous system NPY NPY Y1 Y2 NPY Osteoblasts Fig NPY regulatory network NPY exerts its actions through both central and peripheral...
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Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx

Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx
... 490– 500 Wolthers KR & Scrutton NS (2007) Protein interactions in the human methionine synthase methionine synthase reductase complex and implications for the mechanism of enzyme reactivation ... of MS During primary turnover, the homocysteine-binding domain (dotted barrel) and the CH3-H4-folate binding-domain (black barrel) form discrete complexes with the cobalamin- binding domain (dark ... show that specific protein protein interactions between hMS and MSR (over and above the need to catalyse the reductive chemistry) are required to promote the insertion of the cobalamin into hMS...
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Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs pdf

Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs pdf
... (2008) A novel plant protein disulfide isomerase family homologous to animal P5 – molecular cloning and characterization as a functional protein for folding of soybean seed-storage proteins FEBS J ... both luminal proteins Generally, PDI family proteins play important roles in folding and quality control of nascent polypeptides [25] In soybean cotyledon, large amounts of seed storage proteins ... formed mixed disulfide complexes with an unidentified protein in the ER Mammalian PDI family protein ERp44 forms transient intermolecular bonds with substrate proteins or with the disulfide donor...
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Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt

Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
... H Shimano Physiology and pathophysiology of the SREBP family SREBP- 1c and lipogenesis The SREBP family consists of three isoforms: SREBP1 a, SREBP- 1c, and SREBP- 2 Each isoform has a different ... Physiology and pathophysiology of the SREBP family H Shimano at G1 [19] In particular, p21 is a direct target of SREBP [20] The role of SREBP- 1a in the regulation of cell growth and the cell cycle ... (2009) 616–621 ª 2008 The Author Journal compilation ª 2008 FEBS 619 Physiology and pathophysiology of the SREBP family 10 11 12 13 14 15 16 620 H Shimano conformation of SCAP, the SREBP escort protein...
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Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins pptx

Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins pptx
... 2008 The Authors Journal compilation ª 2008 FEBS 6061 DSPs and the cytoskeleton C Vale and L M Botana Diarrheic shellfish toxins and cell adhesion The adherence of cells to each other and to the ... dinophysistoxins and analogs) affect Ser ⁄ Thr protein phosphatases and their effects on cell adhesion and cytoskeletal dynamics, the disruption of which is linked to loss of cell polarity, and ... study the effect of toxins on neuronal function Similar alterations in the actin cytoskeleton were produced by OA and DTX1 in the human cell lines HEp-2 and Caco-2, derived from larynx and colon...
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Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: a new view of palytoxin toxicity ppt

Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: a new view of palytoxin toxicity ppt
... believed that the role of this system was mainly structural, providing the support needed to maintain the shape and organization of the cell and the scaffolding for the actions of catalytic molecules ... C Louzao et al Distortion of the Na+ pump At the cellular level, a broad range of studies have indicated that the Na+ pump or Na+ ⁄ K+-ATPase is the higher-affinity cellular receptor for palytoxin ... clupeotoxism) and respiratory intoxications Palytoxin enters the food chain and accumulates mainly in fishes such as sardines, 6068 herrings and anchovies from tropical seas, causing neurological and gastrointestinal...
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Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin pptx

Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin pptx
... monomeric actin and actin severing because of the rapid depolymerization that they induce [31,34] However, jasplakinolides induce actin polymerization, stabilizing actin filaments and actin nucleation ... between the PTX-bound actin monomer and the lower lateral actin monomer within the filament, thereby capping the barbed end without inducing filament severing, even though, on the basis of the previous ... supports the idea that lactone ring integrity is essential for the action of PTXs; oxidation on C43 decrease the toxicity of the molecule, and oxidation on C34 does not affect the potency of PTXs Unusual...
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Tài liệu Báo cáo khoa học: Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni pdf

Tài liệu Báo cáo khoa học: Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni pdf
... 2007 FEBS 4087 SmSmad1B, a BMP -R-Smad ortholog from S mansoni J M Carlo et al enhanced the interaction of SmSmad2 and SmSmad4 and resulted in the formation of a stable and functional Smad complex ... degree of homology with BMP-related R-Smads (Smads 1, and ⁄ 9) from different species Smad5 orthologs from the domestic dog (Canis familiaris), the common chimpanzee (Pan troglodytes) and the ... schistosomes, and that a second type I receptor capable of transmitting BMP-related signals may be present in the genome of S mansoni Herein, we report the isolation of a new member of the S mansoni R-Smad...
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Tài liệu Báo cáo khoa học: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory doc

Tài liệu Báo cáo khoa học: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory doc
... Crystal structure of E53QbsSHMT and its complexes Table Data collection statistics of E53QbsSHMT and its complexes Values in parantheses correspond to highest resolution bin Ligand(s) used None Gly ... belonged to the P21212 space group and contained one monomer in the asymmetric unit Cell dimensions and details of data collection are shown in Table Expression and purification of bsSHMT and E53QbsSHMT ... the enzyme conformation previously exposed to glycine and FTHF is different from that before exposure and that E53QbsSHMT exhibits enzyme memory The slow conformational change seen in the E53QbsSHMT...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf

Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... (0.04) (0 .19 ) (0.09) 19 83 2493 14 86 18 85 10 30 16 30 13 45 10 38 19 60 805 514 (406) (13 74) (780) ( 710 ) ( 613 ) (809) (740) (542) (10 47) (752) (277) 19 64 15 61 1008 15 96 905 12 97 11 42 468 14 03 276 206 ... S1 Bar graph of R1, R2 and {1H} 15 N NOE values along the sequence of the TTF1 HD at 11 .7 T and 286 K 448 Fig S2 Plot of J(0.87xN)–J(0) correlation from 15 N relaxation measurements of the TTF -1 ... dynamics of the HD recognition helix upon DNA binding [11 ] 436 In the following, we present a 15 N-NMR relaxation study of the rat TTF -1 HD to address the backbone dynamics in solution 15 N-NMR...
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