Applied biochemistry and biotechnology mélody dutot, roxane fagon, marc hemon, patrice rat antioxidant, anti inflammatory, and anti senesce

... potent antioxidant, antiinflammatory, and pro-SIRT1 activities Such an extract, able to prevent ROS production and cytokine release and to stimulate SIRT1, is very promising in antiaging therapies ... nodosum extract has antioxidant properties when incubated at 0.1 and 0.2 % At higher concentration (0.5 %), A nodosum extract has no more antioxidant properties on our model The dual antioxidant/prooxidant ... apoptosis [7] and SIRT1 overexpression antagonizes cellular senescence [8] To maintain redox balance, organisms require a network of antioxidant systems, as well as a functioning antioxidant defense...

Algae: Anatomy, Biochemistry, and Biotechnology - Chapter 3 docx

... reduction of 3- PG to the level of carbohydrate This reaction occurs in two steps: (1) phosphorylation of 3- PG by ATP to form a 1 , 3- biphosphoglycerate (1 , 3- BPG) and (2) reduction of 1 , 3- BPG by NADPH ... Lhca1 and Lhca4 and homodimers composed of Lhca2 and Lhca3 Those dimers create a half-moon-shaped © 2006 by Taylor & Francis Group, LLC Photosynthesis 1 43 belt that docks to PsaA and PsaB and to ... Algae: Anatomy, Biochemistry, and Biotechnology 136 TABLE 3. 1 Sun Light Reﬂected by Sea Surface Angle between Sun rays and zenith Percentage of reﬂected light 08 108 208 2.1 30 8 2.1 408...

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Algae: Anatomy, Biochemistry, and Biotechnology - Chapter 5 ppt

... Conversiona 380 390 400 410 420 430 440 450 460 470 480 490 50 0 50 7 51 0 52 0 53 0 54 0 55 0 55 5 56 0 57 0 58 0 59 0 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 0.000039 0.000120 0.000396 ... 153 6.800 1669.400 1700.000 1694.900 158 9 .50 0 1378.700 11 05. 000 817.700 683.000 55 8.960 352 .920 206.040 111. 350 56 . 355 27.081 12 .52 9 5. 670 2 .54 5 1. 151 0 .53 2 0. 252 0.122 0.060 0.030 0.016 0.008 0.004 ... 679 .55 1 683.000 679 .58 5 650 .216 59 4.210 51 7.031 430.973 343 .54 9 260.223 180.9 95 119 .52 5 73.081 41.663 21. 856 11.611 5. 607 2.802 1.428 0.7 15 0. 355 0.170 0.082 0.041 0.020 0.00 058 9 0.002209 0.009290...

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Algae: Anatomy, Biochemistry, and Biotechnology - Chapter 2a doc

... is cruciate with a 4-2 - 4-2 system in the tetraflagellate Pyramimonas and Tetraselmis, a 4-2 - 0-0 system in Mantoniella squamata, due to the reduction of one of the two flagella, and to its © 2006 ... ventral root; and TSC, transversely striated connective lack of roots, a 4-3 - 0-( 7-1 2) system in Nephroselmis, and a 4-6 - 4-6 system in Mesostigma When four microtubular roots are present, as in ... zoospores and biflagellate gametes) not follow the X-2-X-2 pattern, but show a 6-4 - 6-4 arrangement in Trentepohlia sp The dorsiventrally compressed form of the flagellate cells forces the basal bodies and...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 1 potx

... High-pressure liquid chromatography (HPLC) Mass spectrometry Immunological approaches to detection of contaminants ix 97 98 10 1 10 2 10 2 10 4 10 5 10 7 10 9 11 0 11 0 11 1 11 1 11 2 11 2 11 6 11 6 11 7 11 8 12 2 ... 11 6 11 6 11 7 11 8 12 2 12 3 12 4 12 7 12 8 12 9 13 3 13 4 14 0 14 2 14 3 14 4 14 5 14 7 15 0 15 3 15 5 15 8 15 9 15 9 16 0 16 1 16 3 16 4 16 6 16 7 16 8 16 8 x CONTENTS Amino acid analysis Peptide mapping N-terminal sequencing ... reading 16 9 17 0 17 1 17 3 17 3 17 4 17 6 17 9 18 0 18 1 18 2 18 3 18 5 Chapter 18 9 The cytokines — the interferon family Cytokines Cytokine receptors Cytokines as biopharmaceuticals The interferons The biochemistry...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 2 potx

... 49, 27 7–304 Normark, B & Normark, S (20 02) Evolution and spread of antibiotic resistance J Intern Med 25 2 (2) , 91–106 Tudzynski, P et al (20 01) Biotechnology and genetics of ergot alkaloids Appl ... non-medical use and relative risks Addiction 92( 3), 26 7 27 7 PHARMACEUTICALS, BIOLOGICS AND BIOPHARMACEUTICALS 41 Kaufmann, C & Carver, P (1997) Antifungal agents in the 1990s — current status and ... biotechnology Curr Opin Biotechnol 10, 525 – 527 Walsh, G (20 00) Biopharmaceutical benchmarks Nature Biotechnol 18, 831–833 Walsh, G (20 02) Biopharmaceuticals and biotechnology medicines: an issue of...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 3 potx

... Anti-coagulants Anti-depressants Anti-diabetic agents Anti-epileptics Anti-fungal agents Anti-gout agents Anti-hypertensive agents Anti-malarials Anti-migraine agents Anti-muscarinic agents Anti-neoplastic ... number of particles per m3 of clean room air Maximum permitted number of viable microorganisms per m3 of clean room air 0.5 mm particle diameter 5.0 mm particle diameter A B C D 35 00 35 00 35 0 000 ... coli Interferon-a Interferon-g Interleukin-2 (IL-2) Granulocyte colony-stimulating factor (G-CSF) Human growth hormone (hGH) E E E E Follicle-stimulating hormone (FSH) CHO Interferon-b CHO Erythropoietin...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps

... interleukins (IL-1 to IL-15) The interferons (IFN-a, -b, -g, -t, -o) Colony stimulating factors (G-CSF, M-CSF, GM-CSF) Tumour necrosis factors (TNF-a, -b) The neurotrophins (NGF, BDNF, NT-3, NT -4 / 5) Ciliary ... IL-2–7, -9 , -1 2, G-CSF, GM-CSF, EPO, LIF, CNTF, GH Receptors for IFN-a, -b, -g , IL-10 Receptors for IL-1, IL-6, FGF, PDGF, M-CSF Receptors for EGF, insulin, insulinlike growth factor-1 (IGF-1) ... ILs, CSFs, TNF, IFN-a and IFN-g Fibroblasts can produce IL-1, IL-6, IL-8, and IL-11, CSFs, INF-b and TNF Many cytokines play a regulatory role in processes other that immunity and inflammation Neurotrophic...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 5 doc

... of 55 kDa, and is known as TNF-R 55 (also P -5 5 , TNFR1 or CD120a) The type II receptor is larger ( 75 kDa) and is known as TNF-R 75 (also P- 75, TNFR2 or CD120b) Both receptors bind both TNF-a and ... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important costimulatory roles in the maturation of the range of blood cells Its growth and differentiation-inducing effects on ... IL-1, IL-1, IL-1, IL-6, IL -5 IL-6, IL-6, IL-6, IL-10, IL-12 IL-8 IL-8, IL-11 IL-8, IL-10 The sum total of biological responses induced by the ILs is large, varied and exceedingly complex These...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 6 potx

... family They include NGF, as well as brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin 4/5 (NT-4/5) and neurotrophin -6 (NT -6 ) All are small, basic proteins sharing ... IGF-1 is a 70 amino acid polypeptide displaying three intra-chain disulphide linkages and a molecular mass of 7 .6 kDa IGF-2 (67 amino acids; 7.5 kDa) also has three disulphide linkages IGF-1 and ... via paracrine- and autocrine-based activity In the human female, IGF-1 is expressed by follicular theca cells, while IGF-2 is synthesized by granulosa cells (Chapter 8) The IGF-1 and -2 receptors...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt

... acetate C2H5-NH-Pro-Arg-Leu-D-Leu-Tyr-Ser-Trp-His-5oxo pro NH2 -Gly-Pro-Arg-Leu-D-Ala-Tyr-Ser-Try-His-5oxo pro j naphthyl NH2 -Gly-Pro-Arg-Leu-Gly-Tyr-Ser-Trp-His-5oxo pro GnRH slow clearance rate ... C2H5-NH-Pro-Arg-Leu-Ser-Tyr-Ser-Trp-His-5oxo pro j butyl Goserelin acetate NH2CO(NH)2-Pro-Arg-Leu-Ser-Tyr-Ser-Trp-His-5oxo pro j butyl Leuprorelin acetate Nafarelin acetate C2H5-NH-Pro-Arg-Leu-D-Leu-Tyr-Ser-Trp-His-5oxo ... systems and strict aseptic technique Biopharmaceuticals: Biochemistry and Biotechnology, Second Edition by Gary Walsh John Wiley & Sons Ltd: ISBN 470 84326 (ppc), ISBN 470 843 27 (pbk) 352 BIOPHARMACEUTICALS...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 8 ppsx

... as a freeze-dried powder and also contains mannitol, sodium citrate, citric acid and polysorbate 80 as excipients It exhibits a shelf-life of years when stored at 28C 88 C An integral part of the ... Blood 84 (3), 680 – 686 Collen, D (19 98) Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent Nature Med 4(3), 279– 284 Collins, R et al (1997) Drug therapy—aspirin, heparin and fibrinolytic ... immunoglobulin G (IgG) Biopharmaceuticals: Biochemistry and Biotechnology, Second Edition by Gary Walsh John Wiley & Sons Ltd: ISBN 470 84 326 (ppc), ISBN 470 84 327 (pbk) 404 BIOPHARMACEUTICALS Antisera...

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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 9 potx

... ( 199 9) Human tumor antigens for cancer vaccine development Immunol Rev 170, 85–100 Winter, G & Milstein, C ( 199 1) Man-made antibodies Nature 3 49, 293 – 299 Vaccine technology Andino, R et al ( 199 4) ... 324–3 29 Ohagan, D et al ( 199 7) Recent advances in vaccine adjuvants — the development of Mf 59 emulsion and polymeric microparticles Mol Med Today 3(2), 69 75 Perkus, M et al ( 199 5) Poxvirus-based ... hydroxylase Branched chain a-ketoacid dehydrogenase Fumarylacetoacetate hydrolase Glucose-6-phosphatase a-L-Fucosidase b-Glucuronidase a-L-Iduronidase Galactose-1-phosphate uridyl transferase...

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