... augments T CR-CD3-mediated activation ofprotein tyrosine kinase p72syk, resulting in incresed tyrosinephosphorylation of adapter proteins, Shc and Cbl. Int. Immunol.10, 833–845.57. Aguirre Ghiso, ... In these protein–protein interactions, t he tetraspanin a ntigens h ave beenproposed to play a costimulatory role [10,22]. Because o fthese protein interactions, tetraspanin antigens can in uenceintracellular ... tetraspanin a n tigens, with at least six different proteinspresent in a specific cell type, suggesting that they form atetraspanin complex composed of different subunits, a sdetected in Burkitt...