... to the wild-type complex. The mutations in the C-terminal Batemandomain of c3 (H453R and R454G), on the other hand, substantiallyreduced the fold stimulation of the complex by 200 lm AMP, and ... of which are required for its activity [8,9]. In the mammalian genome, two isoforms of the a-subunit (a1 and a2) and the b-subunit (b1 and b2), and three iso-forms of the c-subunit (c1, c2 and ... conserved fea-tures in the alignment, using a default colorcode of CLUSTALX. Above the alignment is the conservation score generated by the program. The enlargement shows details of the mutations, with...