... mentioned The mail- coach system had its origin in the West of England, and Bristol and Bath in particular are associated with all the traditions of the initiatory stages, so that the details on ... was at the same time so cheap that the cost of conveyance was only a small item in the expenses of the Post Office The Mayor of Bath proposed the t...
... axon terminal in the sinus gland, as a result of late and progressive isomerization of the Phe3 of the CHH during the migration of the secretion vesicles along the axonal tract [39,41] The immunohistochemical ... (vitellogenesis inhibiting hormone) and CHH (crustacean hyperglycemic hormone) of the crustacean have the same precursor? Immunolocalization...
... evaluate the effects of ionic strength and Mg2+ on the activity and specificity of OGG1, we measured the apparent values of k2 and k3 under conditions of low salt (KPi only) and no Mg2+, low salt and ... Effects of ionic strength and divalent cations on the activity and specificity of Fpg and OGG1 The conditions inside a living cell differ from...
... determined with the free somatic form using inhibitor profiles (Tables and 2) validates the use of selective inhibitors as convenient tools to study the specificity of the somatic form of ACE Thus, ... were applied to the atomic position of several sets of atoms The harmonic constants were set to 100, and 0.5 kcalÆ ˚ mol)1ÆA)2 for the ions and t...
... isomers of retinol and retinal, including the 11 -cis-retinoids involved in photosensitivity Kinetic properties and its localization in many retinal cell layers support the involvement of ADH4 in the ... notably increased in the docked 11-cis-retinal, suggesting that the distinct location of the substrate in the binding pocket of ADH4 is the reason for...
... to the solvent, thus allowing for the binding of larger substituents (Fig 2A) The CH atoms of the substrate ring at positions and point towards the backbone of Leu248 and the side chain of Thr249, ... shown) The contacts between the edge of the dihydroxylated substrate ring and the active site pocket are probably involved in the determination of...
... substrate Therefore, the metal ion has a catalytic rather than just a substrate binding role Possible roles of the cation include the activation of water for the hydration reaction and ⁄ or the ... stabilization of the anion transition state In the latter case, if the substrate coordination to the metal ion is not bidentate, interaction of the...
... discrimination We anticipate that the performance of the potential will only increase with the size of the structural database and as terms are added to the model to account for protein and RNA intra-molecular ... structural data available for training Nevertheless, the distancedependent potential function already performs on par with the amber and rosetta force...
... 4¢-phosphopantothenoylcysteine synthetase CoaB (Eur J Biochem 271) 169 Fig Analysis of the enzymatic activity of His -CoaB R206Q and A276V The synthesis of 4¢-phosphopantothenoyl-CMP (–cysteine, upper part of the figure) and ... important for the second-half reaction and are part of the active-site of CoaB; these residues may be directly involved in bind...
... considers the 4541 Interaction of arginase II with substrate and manganese ions ´ V Lopez et al Table Kinetic properties of the arginase activities of wild-type and mutant variants of human arginase II ... activity of the Asn14 9Asp variant, it is clear that the interactions of arginase II with l-arginine and agmatine are greatly altere...
... NADP+ can arise If we assume the use of a commercial NADP+ containing 0.3% NAD+, as in the case of the Roche sample used in this study, then in a steady-state assay, as in the rapid-reaction ... reaction of wild-type clostridial glutamate dehydrogenase with NADP+ (A) The main panel shows the reaction of 15 lM glutamate dehydrogenase with mM...
... filled, appears to the best advantage, and then any person who has a taste for theatrical amusements, neatness and elegance, cannot fail being agreeably entertained with the appearance of the audience, ... A Concise History and Directory of the City by C Berry A CONCISE HISTORY AND DIRECTORY OF THE CITY OF NORWICH; For 1811: Containing bes...