The Detective and the Author: City of Glass

Tài liệu The King''''s Post Being a volume of historical facts relating to the Posts, Mail Coaches, Coach Roads, and Railway Mail Services of and connected with the Ancient City of Bristol from 1580 to the present time pdf

Tài liệu The King''''s Post Being a volume of historical facts relating to the Posts, Mail Coaches, Coach Roads, and Railway Mail Services of and connected with the Ancient City of Bristol from 1580 to the present time pdf

... mentioned The mail- coach system had its origin in the West of England, and Bristol and Bath in particular are associated with all the traditions of the initiatory stages, so that the details on ... was at the same time so cheap that the cost of conveyance was only a small item in the expenses of the Post Office The Mayor of Bath proposed the t...
Ngày tải lên : 17/02/2014, 02:20
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Tài liệu Báo cáo khoa học: Molecular and cellular specificity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx

Tài liệu Báo cáo khoa học: Molecular and cellular specificity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx

... axon terminal in the sinus gland, as a result of late and progressive isomerization of the Phe3 of the CHH during the migration of the secretion vesicles along the axonal tract [39,41] The immunohistochemical ... (vitellogenesis inhibiting hormone) and CHH (crustacean hyperglycemic hormone) of the crustacean have the same precursor? Immunolocalization...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf

Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf

... evaluate the effects of ionic strength and Mg2+ on the activity and specificity of OGG1, we measured the apparent values of k2 and k3 under conditions of low salt (KPi only) and no Mg2+, low salt and ... Effects of ionic strength and divalent cations on the activity and specificity of Fpg and OGG1 The conditions inside a living cell differ from...
Ngày tải lên : 18/02/2014, 18:20
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Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx

Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx

... determined with the free somatic form using inhibitor profiles (Tables and 2) validates the use of selective inhibitors as convenient tools to study the specificity of the somatic form of ACE Thus, ... were applied to the atomic position of several sets of atoms The harmonic constants were set to 100, and 0.5 kcalÆ ˚ mol)1ÆA)2 for the ions and t...
Ngày tải lên : 16/03/2014, 13:20
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Báo cáo khoa học: The specificity of alcohol dehydrogenase with cis-retinoids Activity with 11-cis-retinol and localization in retina docx

Báo cáo khoa học: The specificity of alcohol dehydrogenase with cis-retinoids Activity with 11-cis-retinol and localization in retina docx

... isomers of retinol and retinal, including the 11 -cis-retinoids involved in photosensitivity Kinetic properties and its localization in many retinal cell layers support the involvement of ADH4 in the ... notably increased in the docked 11-cis-retinal, suggesting that the distinct location of the substrate in the binding pocket of ADH4 is the reason for...
Ngày tải lên : 23/03/2014, 12:20
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Báo cáo khoa học: The role of residue Thr249 in modulating the catalytic efficiency and substrate specificity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1 ppt

Báo cáo khoa học: The role of residue Thr249 in modulating the catalytic efficiency and substrate specificity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1 ppt

... to the solvent, thus allowing for the binding of larger substituents (Fig 2A) The CH atoms of the substrate ring at positions and point towards the backbone of Leu248 and the side chain of Thr249, ... shown) The contacts between the edge of the dihydroxylated substrate ring and the active site pocket are probably involved in the determination of...
Ngày tải lên : 30/03/2014, 10:20
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Báo cáo khoa học: Determination of the metal ion dependence and substrate specificity of a hydratase involved in the degradation pathway of biphenyl/chlorobiphenyl pot

Báo cáo khoa học: Determination of the metal ion dependence and substrate specificity of a hydratase involved in the degradation pathway of biphenyl/chlorobiphenyl pot

... substrate Therefore, the metal ion has a catalytic rather than just a substrate binding role Possible roles of the cation include the activation of water for the hydration reaction and ⁄ or the ... stabilization of the anion transition state In the latter case, if the substrate coordination to the metal ion is not bidentate, interaction of the...
Ngày tải lên : 30/03/2014, 15:20
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Báo cáo khoa học: Substrate and inhibitor specificity of Mycobacterium avium dihydrofolate reductase pptx

Báo cáo khoa học: Substrate and inhibitor specificity of Mycobacterium avium dihydrofolate reductase pptx

... (1983) Directed mutagenesis of dihydrofolate reductase Science 222, 782–788 Hartman PG (1993) Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors J Chemother 5, 369–376 ... Barrow WW (1998) Susceptibilities of Mycobacterium tuberculosis and Mycobacterium avium complex to lipophilic deazapteridine derivatives, inhibitors of dihydrofolate...
Ngày tải lên : 16/03/2014, 10:20
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Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins ppt

Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins ppt

... discrimination We anticipate that the performance of the potential will only increase with the size of the structural database and as terms are added to the model to account for protein and RNA intra-molecular ... structural data available for training Nevertheless, the distancedependent potential function already performs on par with the amber and rosetta force...
Ngày tải lên : 18/02/2014, 16:20
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Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx

Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx

... 4¢-phosphopantothenoylcysteine synthetase CoaB (Eur J Biochem 271) 169 Fig Analysis of the enzymatic activity of His -CoaB R206Q and A276V The synthesis of 4¢-phosphopantothenoyl-CMP (–cysteine, upper part of the figure) and ... important for the second-half reaction and are part of the active-site of CoaB; these residues may be directly involved in bind...
Ngày tải lên : 19/02/2014, 12:20
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Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx

Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx

... considers the 4541 Interaction of arginase II with substrate and manganese ions ´ V Lopez et al Table Kinetic properties of the arginase activities of wild-type and mutant variants of human arginase II ... activity of the Asn14 9Asp variant, it is clear that the interactions of arginase II with l-arginine and agmatine are greatly altere...
Ngày tải lên : 20/02/2014, 02:21
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Báo cáo khoa họcRe-engineering the discrimination between the oxidized coenzymes NAD+ and NADP+ in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme docx

Báo cáo khoa họcRe-engineering the discrimination between the oxidized coenzymes NAD+ and NADP+ in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme docx

... NADP+ can arise If we assume the use of a commercial NADP+ containing 0.3% NAD+, as in the case of the Roche sample used in this study, then in a steady-state assay, as in the rapid-reaction ... reaction of wild-type clostridial glutamate dehydrogenase with NADP+ (A) The main panel shows the reaction of 15 lM glutamate dehydrogenase with mM...
Ngày tải lên : 06/03/2014, 00:20
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A Concise History and Directory of the City of Norwich for 1811 pptx

A Concise History and Directory of the City of Norwich for 1811 pptx

... filled, appears to the best advantage, and then any person who has a taste for theatrical amusements, neatness and elegance, cannot fail being agreeably entertained with the appearance of the audience, ... A Concise History and Directory of the City by C Berry A CONCISE HISTORY AND DIRECTORY OF THE CITY OF NORWICH; For 1811: Containing bes...

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