... irritant- nduced a i asthma, and reactive airway dysfunction syndrome (RADS) alone and in combination with epidemiology, diagnosis, and treatment Both primary literature and recent reviews were included ... of r compounds and mediated by a variety of mechanisms Specifically, OA can be immunologically mediated by both high- (HMW) and low- olecular- eight (LMW) substances and m w may also be non–immunologically ... history with emphasis on childhood respiratory symptoms, history of atopy, previous home and work exposures, and cigarette smoking.17,22 It is crucial to understand the patient’s current symptoms,...