... bred in a barrier facility (John P Robarts Barrier Facility, London, Ontario, Canada) and maintained at a conventional animal housing facility (Animal Care and Veterinary Services, University of ... within the candidate endogenous arthritogenic antigens CII and hAG, and the exogenous antigen HBsAg; determine whether a correlation exists between peptide–DR4 affinity and T-cell activation; and ... binding score for a peptide’s affinity Binding scores of more than are predicted to have a high affinity for DR4 Using this predictive model, we analyzed human CII, the first globular domain and...