Development and validation of a generic assay to detect compounds acting via an aggregation based mechanism
Development and validation of a generic assay to detect compounds acting via an aggregation based mechanism
... Plate reader-mostly fluorescence, luminescence and absorbance Reporting format “Representative” data; statistical analysis of manually curated dataset Automated analysis of all data using statistical ... establish viability of application Furthermore, a generic assay that could be applied to any HTS campaign to eliminate inhibitors acting via an aggregation- based mechanism would be of great benefit ... signal means of the positive and negative controls) with small standard deviations Z-factors can never be greater than A value between 0.5 and is aspired for in HTS settings A Z-factor between and...
- 86
- 1,146
- 0
Báo cáo y học: " Development and validation of a complementary map to enhance the existing 1998 to 2008 Abbreviated Injury Scale map" doc
... from the dictionary map This is referred to as the complementary map Validation of the combined map formed by amalgamating the complementary map with the current dictionary map This combined map ... referred to as the ‘enhanced map The performance of the enhanced map was evaluated against the performance of the dictionary map alone by using double-coded AIS data In addition, the value of free ... AIS98 data mapped forwards to AIS08 equivalents using the dictionary map; • EMap08 - AIS98 data mapped forwards to AIS08 equivalents using the enhanced map (that is, both the dictionary and complementary...
- 13
- 688
- 0
Báo cáo hóa học: " Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood" pptx
... biomarkers, and they participated in the data analyses AAH developed the customized Spotfire tool used for data analyses and reviewed statistical analyses YG participated in the assessment and ... assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood Journal of Translational Medicine 2010, 8:51 Page 13 of 13 ... this basic approach (ex vivo stimulation of whole blood) to develop pharmacodynamic biomarker assays for a candidate therapeutic antibody, Ab-01 Ab-01, a human antibody generated by phage display,...
- 13
- 528
- 0
Báo cáo y học: "Development and Validation of a HPV-32 Specific PCR Assay" pps
... additional 78 HPV-32 positive samples were identified that were negative by the dot blot assay The HPV-32 type specific PCR assay has a sensitivity of 95.8% and a specificity of 87.8% with a kappa of ... sensitivity, thus a HPV-32 type specific PCR assay was developed and optimized Sensitivity, specificity, and reproducibility are critical to the development of any new assay The sensitivity of the HPV-32 ... current assays In addition, this assay is highly reproducible and is less labor-intensive This makes the assay ideal to assess the natural history of HPV32 in the oral cavity Materials and methods...
- 7
- 424
- 0
Báo cáo khoa học: "Development and Validation of a HPV-32 Specific PCR Assay" ppsx
... dot blot assay The HPV-32 type specific PCR assay has a sensitivity of 95.8% and a specificity of 87.8% with a kappa of 0.32 ± 0.029 as compared to the HPV-32 dot blot assay When analyzed according ... Extracted the clinical samples and tested them via the PGMY and HPV-32 dot blot assay JEC: Developed and validated the HPV-32 dot blot assay used at the comparison assay for the HPV-32 specific PCR ... amplicons were detected and visualized as described above The primer sequences for the HPV-32 specific PCR were 5' GTG GCC GCC TAG TGA CAA C 3' (HPV-32 Det For) and 5' GAT GCC CAA CAG CCA AAA...
- 7
- 352
- 0
Báo cáo y học: "andidemia on presentation to the hospital: development and validation of a risk score" pptx
... presentation on admission as candidate variables, which is likely to be a strength of our paper because many large-scale databases tend to only have the results of administrative coding and lack actual ... Cox, and Linda Hyde are employees of Cardinal Health Authors' contributions AFS contributed to study concept and design, analysis and interpretation of data, drafting the manuscript, critical revision ... or material support and study supervision RSJ contributed to study concept and design, acquisition of data, analysis and interpretation of data, drafting the manuscript, critical revision of the...
- 10
- 394
- 0
báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc
... designed and managed the valuation survey, analysed and reported on the valuation data and contributed to the writing of the manuscript All authors read and approved the final manuscript Acknowledgements ... state Validation of the preference based CAMPHOR scale A majority (87.8%) of the 91 participants in the CAMPHOR validation survey were in New York Heart Association (NYHA) classes II and III The ... group for use in the UK valuation of the EQ-5D For health states that a respondent regards as better than being dead, they are asked to imagine two scenarios: 1) live in a state for 10 years (t) and...
- 8
- 590
- 0
báo cáo hóa học: " Development and validation of a French patient-based health-related quality of life instrument in kidney transplant: the ReTransQoL" pot
... data management, analyzed and interpreted the data, drafted the manuscript; EJ participated in the design of the study, collected the data and performed the statistical analysis BD and VM: participated ... regarding the psychosocial and physical impact of kidney transplantation [4,5] Kidney transplantation is the therapy of choice for endstage renal failure when focusing on survival transplantation ... data management and the English translation of the draft References Spiker BN: Quality of life and phamarcoeconomics in clinical trials 2nd edition Philadelphia, NY: Lippincott-Raven; 1996 Ganz...
- 12
- 520
- 0
Báo cáo hóa học: " Development and validation of a Greek language version of the Manchester Foot Pain and Disability Index" docx
... Figure Greek language version of the Manchester Foot Pain and Disability Index Greek language version of the Manchester Foot Pain and Disability Index Page of (page number not for citation purposes) ... reported foot pain were asked to indicate the location of the pain on eight diagrams of the feet The participants then completed the Greek language version of the MFPDI A total score for the MFPDI was ... evaluation of the Manchester Foot Pain and Disability Index Rheumatology 2006, 45:863-867 Garrow AP, Silman AJ, Macfarlane GJ: The Cheshire Foot Pain and Disability Survey: a population survey assessing...
- 9
- 481
- 0
báo cáo hóa học:" Development and evaluation of a clinical algorithm to monitor patients on antiretrovirals in resource-limited settings using adherence, clinical and CD4 cell count criteria" ppt
... (VF) in TwoUgandans on ART at the Infectious Diseases Institute in Two clinical algorithms to monitor for viral failure (VF) in 496 Ugandans on ART at the Infectious Diseases Institute in Kampala, ... cross-sectional study of 496 Ugandans established on NNRTI-based ART We evaluated combinations of adherence, clinical and laboratory variables to determine viral failure Study setting This study was ... NN, Onwujekwe DI, Audu RA, Araoyinbo ID, Onyewuche JI, Salu OB, Adedoyin JA, Musa AZ: Management of HIV-1 infection with a combination of nevirapine, stavudine, and lamivudine: a preliminary...
- 10
- 533
- 0
báo cáo hóa học:" Development and validation of a psychosocial screening instrument for cancer" potx
... of validity Finally, raw means and standard deviations are provided for each cancer type and each gender group (Table 4) This presentational approach appeared more parsimonious and provided a ... initial data for a 3-month time period rather than setting a particular sample size as a target; the rationale for this decision was to allow us later determination what percentage of the total ... Hospital anxiety and Distress Scale PSCAN Psychosocial Screen for Cancer 18 HRQoL Health-Related Quality of Life 19 SNSA Social Network and Support Assessment Additional material Additional File...
- 7
- 463
- 0
báo cáo hóa học:" The positive mental health instrument: development and validation of a culturally relevant scale in a multi-ethnic asian population" pdf
... Institute of Mental Health and the Domain Specific Review Board of the National Healthcare Group, Singapore Ethical approval covered all aspects of the study including design, sample size and selection, ... all components of PMH scale would have negative correlation with the GAD-7, SDS and PHQ-8 scales All statistical significance was set at a p value of less than 0.05 Vaingankar et al Health and ... mental health training, education and public awareness An additional implication of using this instrument in a research setting will be to measure and observe changes to positive mental health among...
- 18
- 487
- 0
báo cáo hóa học:" Validation of the Self-Management Ability Scale (SMAS) and development and validation of a shorter scale (SMAS-S) among older patients shortly after hospitalisation" doc
... Validation of the Self-Management Ability Scale (SMAS) and development and validation of a shorter scale (SMAS-S) among older patients shortly after hospitalisation Jane M Cramm*, Mathilde ... Preparation of the paper; acquisition of subjects and data; final approval of the version to be published NS: Preparation of the paper; analyses and interpretation of data; final approval of the version ... interpretation of data; final approval of the version to be published MS: Preparation of the paper; analyses and interpretation of data; final approval of the version to be published PV: Preparation of...
- 24
- 305
- 1
báo cáo khoa học:" Development and validation of a questionnaire on ‘Satisfaction with dermatological treatment of hand eczema’ (DermaSat)" potx
... doi:10.1186/1477-7525-8-127 Cite this article as: Ruiz et al.: Development and validation of a questionnaire on ‘Satisfaction with dermatological treatment of hand eczema’ (DermaSat) Health and Quality of Life Outcomes ... medical care Additional material Additional file 1: Spanish version of the DermaSat questionnaire Original Spanish version of the DermaSat questionnaire measuring satisfaction with treatment of hands, ... satisfaction Val Health 2005, 8(Suppl 1):S2-S5 18 Atkinson MJ, Sinha A, Hass SL, et al: Validation of a general measure of treatment satisfaction-the Treatment Satisfaction Questionnaire for Medication...
- 16
- 439
- 0
báo cáo khoa học:" Development and validation of a short version of the Assessment of Chronic Illness Care (ACIC) in Dutch Disease Management Programs" doc
... Cite this article as: Cramm et al.: Development and validation of a short version of the Assessment of Chronic Illness Care (ACIC) in Dutch Disease Management Programs Health and Quality of Life ... selfreport ACIC data from the initiators of the 22 projects enrolled in the national programme on disease management of chronic diseases” and (ii) self-report ACIC data from all professionals of all ... expressed in the paper are those of the authors 19 Authors’ contributions AN drafting the design for data gathering JC, AN and AT were involved in acquisition of subjects and data JC, AN and MS...
- 10
- 392
- 0
Từ khóa: a reporter assay to detect transfer and targeting of mirnas in stem cell breast cancer co culturesdevelopment and use of a risk reference frameworkkrishnamurti 1991 the landfall and structure of a tropical cyclone the sensitivity of model predictions to soil moisture parameterizations boundary layer meteorolory 55 345 380along with the development and upgrade of hybrid rice technology the market for hybrid rice seed increased 111 fold from 0 14 million ha in 1976 to 15 4 million ha in 2000 hybrid rice would not have been succes8 find the radius and center of a circle to fit within a page elementdevelopment deployment and usability of a point of care decision support system for chronic disease management using the recently approved hl7 decision support service standardthe rise and fall of a right to asylumii any filings on behalf of owners and operators of a nox budget unit or nox budget source shall be signed by the nox authorized account representative any filing on behalf of persons with an ownership interest with respect to nox allowances in ageneral ideas and development the definition of a microstatemen s help seeking development and evaluation of the barriers to help seeking scalevirtual and augmented reality a new approach to aid users of myoelectric prostheses4 aberrations of normal development and involution andi a concept of benign breast disorders based on pathogenesispractical experiences post assay development and validationto work with award holders on the development and implementation of their evaluation plansnatural mould and soil of a gardenBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP