... important considerations exist in assessing the effects of estrogens and progestins broadly on the serum proteome The preparations considered here are conjugated equine estrogen and medroxyprogesterone ... cardiovascular disease, and fractures, among others The addition of 2.5 mg/d medroxyprogesterone acetate to 0.625 mg/d conjugated equine estrogen may have an impact on the IGF Authors’ contributions SJP, SMH, ... of potential relevance to the less-favorable E+P effects, compared with those for E-alone, on breast cancer, and CHD Similarly the addition of medroxyprogesterone acetate may also augment the effects...