... Cytologically, centromeres of mitotic and meiotic chromosomes appear as sites of avid cohesion, and may, in fact, direct the formation and maintenance of a centromere-proximal domain of cohesin and other ... nondisjunction and loss [17,19–24] SCC at or near the centromere clearly opposes the MT-dependent pulling forces exerted by the spindle prior to the onset of anaphase, and therefore helps to prevent ... review in further detail the nature of centromeric chromatin and SCC and the relationship between them THE NATURE OF CENTROMERIC CHROMATIN Centromeres are defined genetically by phenotypic or molecular...