... demonstrated that the regulation of CD59 by statins in hypoxia was inhibited by mevalonate and geranylgeraniol, confirming a role for inhibition of HMG-CoA reductase and geranylgeranylation, respectively ... anti-inflammatory action of statins in RA The combined effects of DAF, at the level of C3 and C5 convertases, and of CD59 inhibiting the terminal attack complex has the potential to exert antiinflammatory ... that cycles of hypoxia and reoxygenation within the synovium may also exacerbate complement activation In situ analysis has demonstrated abundant local synthesis of C3, C3aR, C5aR and C5b-9 at...