Role of bcl 2 in metabolic and redox regulation via its effects on cytochrome c oxidase and mitochondrial functions in tumor cells
Role of bcl 2 in metabolic and redox regulation via its effects on cytochrome c oxidase and mitochondrial functions in tumor cells
... treated CEM /Bcl- 2 cells Indeed, if MnSOD was engaged in blunting mitochondrial O2- increase in antimycin-treated CEM /Bcl- 2 cells due to increased activity in the context of Bcl- 2 overexpression, ... a conformational change in Bcl- 2, exposing its BH3 domain, converting Bcl- 2 from anti-apoptotic to pro-apoptotic (Lin, Kolluri et al 20 04) 1.6 Non-canonical role of Bcl- 2 in redox regulation: ... increases in COX activity and oxygen consumption This observation corresponded to the maintenance of mitochondrial O2- levels in the Bcl- 2 cells while the levels in nonoverexpressing cells continue...
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Báo cáo khoa học: "Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis" docx
... Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis 281 Table Bcl-2 immunoreactivity in cell phenotypes of the spinal cords of normal and EAE rats ... Tae-Kyun Shin Fig Immunostaining for Bcl-2 (A, B) in EAE Intense Bcl-2 immunoreactivity is found in neurons and glial cells in the spinal cords of normal rats (A) In EAE, intense Bcl-2 immunoreactivity ... Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis 283 10 11 12 13 14 15 Mice overexpressing Bcl-2 in their neurons are resistant to myelin oligodendrocyte...
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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... bone fracture healing J Bone Miner Res 2002, 17:963-976 Einhorn TA Do inhibitors of cyclooxygenase-2 impair bone healing? J Bone Miner Res 2002, 17:977-978 Zhang X, Schwarz EM, Young DA, Puzas ... activity of a glucocorticoid-regulated inflammatory cyclooxygenase Proc Natl Acad Sci USA 1992, 89:4888-4892 Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflammatory therapy Am J ... selectivity of this group of compounds might allow inflammation to be inhibited with minimal effects on certain homeostatic mechanisms, their role in bone metabolism and repair remains unclear Review of...
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Báo cáo y học: "Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells" pot
... scanned and digital images of proteins were analyzed Calpain activity Calpain activity was measured as described by Tompa et al [26] Cells were washed with and scraped in ml of icecold PBS, and ... activation in a therapeutically useful manner In any case, the results here indicate that COX-2 is degraded by calpain, and that PIN1 regulates its expression via effects on calpain activity in MAEC ... partial reduction of calpain activity may be due to the incomplete (85%) suppression of PIN1 by the shRNA [6] PIN1 may also function as a modulator of calpain activity and not as an absolute requirement...
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Báo cáo y học: "Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome" ppsx
... potent COX-2 inhibitor, etodolac, attenuated cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome This is the first report indicating the modulating role of COX-2 in ... important to clarify the potential mechanisms of chronic productive cough in patients suffering from sinobronchial syndrome to improve their symptoms more early COX is the key enzyme in the pathway of ... clearly showed the beneficial effect of two-week treatment with etodolac for cough reflex sensitivity to inhaled capsaicin So we can consider that COX-2 plays some roles in controlling cough reflex...
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ELUCIDATING THE ROLE OF BNIP 2 IN ZEBRAFISH EARLY DEVELOPMENT
... 28 2. 1 Fish Spawning and Maintenance 28 2. 2 Molecular Biology Techniques 28 2. 2.1 RT-PCR Molecular Cloning 28 2. 2 .2 Polymerase Chain Reaction (PCR) 29 2. 2.3 Agarose Gel Electrophoresis 29 2. 2.4 ... prior finding of possibly interacting proteins of BNIP- 2 led to the formation of research questions: Does the physical interaction of BNIP- 2 with these proteins mean that BNIP- 2 operates in the ... activity of the gene to study the effect of gain -of- or loss-offunction of the gene 20 As have been mentioned, based on earlier findings of BNIP- 2, we hypothesised that BNIP- 2 is involved in GTPase-mediated...
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Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome docx
... Rhee SG (20 01) Inactivation of human FEBS Journal 27 5 (20 08) 29 42 29 55 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 29 53 Cysteinyl-based modification of the 20 S proteasome 10 11 12 13 14 15 ... investigating whether that common feature is related to their easy entry into the latent 20 S particle Cysteinyl-based modification of the 20 S proteasome According to our data, Grx2 is ubiquitinated ... preparations obtained FEBS Journal 27 5 (20 08) 29 42 29 55 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 29 43 Cysteinyl-based modification of the 20 S proteasome G M Silva et al from cells grown in glycerol...
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Báo cáo khoa học: The role of residue Thr249 in modulating the catalytic efficiency and substrate specificity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1 ppt
... to the solvent, thus allowing for the binding of larger substituents (Fig 2A) The CH atoms of the substrate ring at positions and point towards the backbone of Leu248 and the side chain of Thr249, ... shown) The contacts between the edge of the dihydroxylated substrate ring and the active site pocket are probably involved in the determination of substrate specificity Inspection of the substrate ... surrounding the binding pocket The two complexes were very similar In both structures, the largest contacts were found between the plane of the substrate ring and the plane of the imidazole ring of residue...
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Báo cáo sinh học: "Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells" pptx
... Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells Journal of Translational ... DNR-insensitive CD34+ AML cell lines (KG1a and Kasumi-1) and in CD34+ primary AML samples We showed that curcumin selectively induced apoptosis in KG1a and Kasumi1 cell lines, as well as in primary CD34+ ... numbers of cells for apoptosis assay by flow cytometry As shown in Figure 7D, E, curcumin induced significant apoptosis in CD34+ AML cells, but minimal apoptosis in normal CD34+ hematopoietic...
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Báo cáo sinh học: "Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft" pot
... efficacy of the bcl-2 ASO G3139 on mice bearing human melanoma in combination chemotherapy, in order to identify an innovative approach for antisense delivery to tumors and to increase the response of ... those areas where aggressive surgery is not feasible, such as head and neck melanoma Adjuvant therapies of metastatic melanoma have been unrewarding with a median survival of to 7.5 months and a ... Natali PG, Leonetti C: Antitumor efficacy of bcl-2 and c-myc antisense oligonucleotides in combination with cisplatin in human melanoma xenografts: relevance of administration sequence Clinical...
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báo cáo hóa học:" Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft" ppt
... tumors and to increase the response of melanoma to therapy The rationale for the use of G3139 is based on the relevant role of bcl-2 in melanoma cell survival and on the increased sensitivity of ... whether electroporation could increase the efficacy of the bcl-2 ASO G3139 on mice bearing human melanoma in combination chemotherapy, in order to identify an innovative approach for antisense delivery ... those areas where aggressive surgery is not feasible, such as head and neck melanoma Adjuvant therapies of metastatic melanoma have been unrewarding with a median survival of to 7.5 months and a...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... article as: Hughes-Fulford and Li: The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization Journal of Orthopaedic Surgery and Research 2011 6:8 Submit ... Figure FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing ... maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc Fgf-2, ...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... article as: Hughes-Fulford and Li: The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization Journal of Orthopaedic Surgery and Research 2011 6:8 Submit ... Figure FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing ... maintained the mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc Fgf-2, ...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... cytokines than the ContDCs, at 24, 48 h of incubation time (Fig 2) However, the taxol concentration used was critical for the level of cytokine production; μg/ml of taxol induced only marginal ... by that of the β-actin band, and the ratio at h was set at 100% (B) Fig NF-κB involvement in the taxol- induced effects on dendritic cells (DCs) The mobilization of NF-κB p65 molecules in DCs was ... may further confirm their role of taxol- treated DCs Although the expression of Bax was increased in TaxolDCs, the expression of Bax occurred later than that of Bcl-xL, which implies that the pro-apoptotic...
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Từ khóa: pfc importance of bcl 2 in preventing apoptosisan example for the role of chemokine receptors in tumor progression and metastasiscrosstalk between vegf and bcl 2 in tumor progression and angiogenesisthe role of ros signaling in tumor progressionrole of pmn mdscs in tumor progressionthe role of cyclooxygenase 2 epidermal growth factor receptor and aromatase in malignant mesothrole of il 7 in immune reconstitution after haart or haart plus il 2 and preclinical assessment of its therapeutic potentialthe role of the courts in patent law and policythe motivating role of positive feedback in sport and physical educationrole of chemical engineer in oil and gas industrythe role of capital market in industrial growth and developmentthe role of capital market in industrial growth and development in nigeriarole of oxidative stress in cadmium toxicity and carcinogenesisthe role of the kidney in type 2 diabetesdefinition and role of activation energy in a chemical reactionchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM