The function of TOM1 l1 in bridging EGFR signaling and endocytosis
The function of TOM1 l1 in bridging EGFR signaling and endocytosis
... THE FUNCTION OF TOM1- L1 IN BRIDGING EGFR SIGNALING AND ENDOCYTOSIS LIU NINGSHENG (M.Med Southeast Univ.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY INSTITUTE OF MOLECULAR AND ... Cloning and Sequencing 2.2 Plasmid Constructs 2.2.1 HA -TOM1- L1, HA -TOM1- L1 Y460F and GFP -TOM1- L1 2.2.2 HA -TOM1- L1 SH3, HA -TOM1- L1 Y392F and HA -TOM1- L1 Y460F & SH3 2.2.3 HA -TOM1- L1- PX and HA -TOM1- L1- PX ... Mediating EGFR Endocytosis 6.1 The C-terminal Tail of TOM1- L1 Harbors a Novel Clathrin-interacting Motif 6.2 TOM1- L1 s Clathrin Binding Motif is Important for its Role in Mediating EGFR Endocytosis...
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Báo cáo khoa học: "A COMFUTATIONAL THEORY OF THE FUNCTION OF CLUE WORDS IN ARGUMENT UNDERSTANDING" potx
... consider these devices as clues, but examine the relations between the use of anaphors and clues in the next section Even w!thin the classification of connectives, there is a question of level of explicitness ... indicating a causal connection, but c) requires a kind of referent resolution as 254 structure reconstruction also allows us to comment on the the function of clue words within analysis The theory ... to note that there has been no effort to date to study the use of clue words extensively, distinguishing cases where they occur and suggesting when clues are necessary The clue theory presented...
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The Function of PsbS Protein in Plant Photosynthesis Regulation
... accordingly to the lack of most of the pigment binding sites present in the other Lhc proteins [20,47] Results from Aspinall-O'Dea and coauthors, indicating zeaxanthin binding to PsbS in vitro ... than in the npq4 mutant [9,20] This indicates that the function of PsbS in qE activation is dominant compared to that one of zeaxanthin in the presence of ∆pH Indeed, the absence of both PsbS ... native PsbS protein does not bind chlorophylls or carotenoids, differently from others Lhc proteins, which maintain full pigment binding in the same conditions [47] Alternatively, the binding of...
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Investigate the function of kinectin isoforms in endoplasmic reticulum dynamics
... brings the total known number of kinectin isoforms in mouse to 16 (Fig 1.2) The identification of total of 16 kinectin isoforms reveals the long-suspected existence of a family of kinectin isoforms ... kDa kinectin of Int4 at the leading edge of migrating cells 60 Chapter Roles of kinectin Int4 in ER dynamics during cell migration and division 63 3.1 Roles of kinectin Int4 in ER dynamics ... demonstrated the importance of kinectin isoforms with Int4 in modulating ER dynamics of interphase cells These findings would serve as a platform for more detailed studies of kinectin isoforms The opportunities...
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báo cáo sinh học:" Doubling the number of health graduates in Zambia: estimating feasibility and costs" pdf
... construction, and management of training institutions Outside of the MoH, the Cabinet Office and the Ministry of Finance control the annual budget for all ministries The Ministry of Education and the Ministry ... significant increase in health training institution graduates [5] In response, the Ministry of Health National Training Plan 2008 provided top-down targets for doubling the number of graduates during ... In increasing the size of their intakes, training institutions anticipated having to accept candidates from regions further from their school, which would present the risk of increasing the number...
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Báo cáo lâm nghiệp:"Predicting the probability of seed germination in Pinus sylvestris L. and four competitor shrub species after fire" doc
... ºC min min min min min min min 94 95 93 90 92 RESULTS Germination results of Scots pine and the four undergrowth species (table I) indicate that the four obligatory seeder species (Pinus sylvestris, ... follows Tutin et al [47] Models of germination of competitor species 77 Table I Percentage of germination of Pinus sylvestris and four shrub species after different thermal chocks and control ... species show a high germination rate after thermal shock, there is a high probability that these species produce a reduction in the Models of germination of competitor species 79 Figure Germination...
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Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot
... the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α in the presence of interleukin-1β ... the work by Yudoh and colleagues adds further experimental evidence for the suggested role of HIF-1 in protecting chondrocytes from cell death induced by pro-inflammatory cytokines Finally, Yudoh ... HIF-1 is of pivotal importance in cartilage development and homeostasis Furthermore, given the decreased oxygen levels and presence of inflammatory mediators during the course of OA, a causal role...
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Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps
... attenuated in the γδ T cell deficient mice Our findings are consistent with a role of γδ T cells in determining the magnitude of the inflammatory response to acute epithelial injury and in maintaining ... hyperresponsiveness and exhibit an attenuated inflammatory response The contribution of γδ T cells to epithelial regeneration in the intestine is not evident in the airways Competing interests The author(s) ... single exposure to chlorine We hypothesized that γδ T- cells were involved in modulating airway responses to methacholine and the repair of airway epithelium after acute chlorine gas exposure The γδ...
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Báo cáo sinh học: " The significance of controlled conditions in lentiviral vector titration and in the use of multiplicity of infection (MOI) for predicting gene transfer events" pot
... viruses, an "infectious unit" refers to the smallest amount of virus capable of producing an infection in a susceptible cell The titre of the original suspension is defined as the number of infectious ... than half of the active vectors had adsorbed to the cells To estimate the t(1/2) of the vector system used here, we pre-incubated the inoculum for increasing periods of time before applying aliquots ... volume of the preparation [1] In the field of gene therapy where viral vectors are used for gene transfer, MOI was adopted to represent the ratio of input infectious units (titrated on the target...
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the role of fgfr3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice
... The role of FGFR3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice Mona Foth Submitted in fulfilment of the requirements for the Degree of PhD ... at the signalling downstream Thirdly, we examined the role of the most common mutation in FGFR3, S249C, in the urothelium and in tumour progression and invasion by subjecting Fgfr3 mutant mice ... signalling in the early stages of non-invasive urothelial carcinoma as well as in tumour progression of established neoplasms in mice Given the wide availability of inhibitors specific to FGF signalling,...
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Báo cáo khoa học: The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor pot
... through RXR To determine whether the influence of USP ⁄ RXR on the EcR function is mediated at the level of heterodimerization between EcR and USP ⁄ RXR, we Influence of RXR on EcR function Fig Comparison ... performance of HsRXR, LmRXR and the two chimeras, Hs–LmRXR (helix 1–8 of HsRXR and 9–12 of LmRXR) and Lm-HsRXR (helix and two loops on either side of helix of LmRXR were replaced with the corresponding ... requires only nanomolar concentrations of ligands for the transactivation of genes and functions well in vivo The RXR chimeras containing most of HsRXR and helix and the loops on either side of helix...
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Báo cáo khoa học: Re-evaluation of the function of the F420dehydrogenase in electron transport ofMethanosarcina mazei potx
... activity of 45 mUặmg)1 of protein (Fig 1), whereas in the cell lysate of the parental strain the activity was 50 mUặmg)1 of protein These ndings clearly indicate that the predominant part of F420H2 ... absent in the cytoplasmic fraction of the DfpoF mutant This observation prompted investigation into the function of FpoF in more detail The corresponding gene, mm0627, was expressed in E coli and the ... reduction in cell lysates of the DfpoA-O mutant or the DfpoF mutant was in the range of mUặmg)1 of protein and hence 10-fold higher than the rate of H2 production from F420H2 in the absence of CoM-S-S-CoB...
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... DISCUSSION The findings in this study show that GR is highly expressed in epithelial cells of the male genital tract, especially in the Ó FEBS 2002 Glutathione reductase in male reproduction system ... level of expression of aldose reductase was also detected in the epithelia of the male genital tract In addition, glutathione S-transferase is present in the male reproductive system [45] Thus, the ... occur in spermatozoa during their migration through the epididymis, the oxidation of sulfhydryls is related to the acquisition of motility [4,5] During epididymial migration, sulfhydryls in the...
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Báo cáo Y học: The function of methyl-menaquinone-6 and polysul®de reductase membrane anchor (PsrC) in polysul®de respiration ofWolinella succinogenes doc
... substitution of D76 by asparagine or leucine resulted in nearly inactive mutants, whereas D76H exhibited about 10% of the wild-type activity of polysulđde respiration The hydroxyl groups of Y2 3 and Y1 59 ... encode the membrane anchor of the enzyme and to carry the site of quinol oxidation Tetrathionate reductase (Ttr) of Salmonella typhimurium is thought to catalyze the reduction of Fig The eect of the ... transfer from the dehydrogenases to polysulđde, indicating that PsrC serves speciđc functions in addition to that of the membrane anchor of Psr The activity of polysulđde respiration in the membrane...
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Chapter 2Communicating Over the Network Quangkien@gmail.com.OverviewDescribe the structure of a network, including the devices and media that are necessary for successful communications. Explain the function of protocols in network communications. Ex potx
... Overview Describe the structure of a network, including the devices and media that are necessary for successful communications Explain the function of protocols in network communications Explain ... be installed – The amount of data and the speed at which it must be transmitted – The cost of the media and installation 17 Local Area Network (LAN) Local Area Network (LAN) An individual network ... running on the intermediary network devices perform these functions: – Regenerate and retransmit data signals – Maintain information about what pathways exist through the network and internetwork...
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Từ khóa: what is the function of application protocol in any network communicationwhat is the function of english language in nigeria societywhat is the function of transport layer in osi modeldiscuss the function of english language in nigeria societyexplain the function of each layer in the osi network modelthe function of english language in nigeria societywhat is the function of layer mask in photoshopthe function of musical instrument in african traditional societyaccording to the function of vocabulary items in a sentencegive a critical analysis of the concept of self defence in public international law and international humanitarian lawthe role of capital market in nigeria economic growth and developmentwhat is the evidence for the effectiveness of physical therapy in clinical practice settings and can the findings in the research settings be generalised to clinical practiceof previous studies on the use of group work in foreign language teaching and learningbioinformatics search of atox1 consensus sequences and response elements in the promoter of genes involved in dna damage response and antioxidant defensewhat is the function of data link layer in osi modelNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP