Pharmacokinetics and pharmacogenetics of mycophenolic acid in asian renal transplant patients in singapore

Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients

... objective of identifying the pharmacokinetic profile of total and free mycophenolic acid (MPA), and mycophenolic acid glucuronide (MPAG) and pharmacodynamic profile of MPA in mycophenolate mofetil ... groups of multiple doing reported in literatures 16 Pharmacokinetic parameters of mycophenolic acid in different transplant groups of multiple doing reported in literatures 20 Pharmacokinetic ... PHARMACOKINETIC AND PHARMACODYNAMIC STUDIES OF MYCOPHENOLIC ACID IN RENAL TRANSPLANT RECIPIENTS NWAY NWAY AYE (B Pharm., Institute of Pharmacy, Yangon, Myanmar)...

PROCEDURES ON IMPORTATION AND REGISTRATION OF A CAR IN SINGAPORE doc

... IMPORTATION AND REGISTRATION OF NEW AND USED CARS IN SINGAPORE Vehicle Registration All motor vehicles in Singapore must be registered with the Land Transport Authority (LTA) Importation of ... will incur a corresponding registration surcharge of between S$5,000 and S$20,000 Details of CEV bandings are as follows: Band A1 A2 A3 A4 B C1 C2 C3 C4 CEV BANDINGS FOR CAR Carbon emission Rebate ... standards as Singapore (at the time of its registration as a new car in Singapore) Fuel Economy Labelling Scheme (FELS) All cars and light goods vehicles are required to have CO2 (in g/km) and...

Incidence and survival of childhood cancers in singapore, 1968 1997 a population based study

... increased incidence of childhood primary malignant brain tumors occurring in the mid-1980s In this study, instead of assuming and testing a ‘linear model’ of the increasing trends of incidence rate ... the incidence and survival rates of childhood cancers from 1968 to 1997 in Singapore, and identify the trends of incidence and survival over the three decades 25 Chapter Materials and Methods Study ... trends in incidence and mortality rates of neuroblastoma in Osaka, Japan, from before and after a nationwide mass-screening program in 1985 They used Great Britain as a control because there was...

Báo cáo khoa học: Fatty acid composition of chylomicron remnant-like particles inﬂuences their uptake and induction of lipid accumulation in macrophages pot

... obtained In summary, this study shows that the fatty acid composition of chylomicron remnants in uences their uptake and induction of lipid accumulation in macrophages, with those enriched in ... fatty acid composition of chylomicron remnants affects their uptake by macrophages and induction of excessive lipid accumulation in the cells In this study, we have investigated the effects of ... THP-1 to investigate the uptake of chylomicron remnants and their induction of lipid accumulation in the cells [4,5,7,19,20] As chylomicron remnants uncontaminated with lipoproteins of a similar...

Báo cáo khoa học: " Pharmacokinetics and bioavailability of doxycycline in ostriches (Struthio camelus) at two different dose rates" potx

... gniretsinimda erofeb h 21 rof dlehhtiw saw dooF ebut hcamots a hguorht yllaro nevig saw dna ,ylevitcepser ,noitartsinimda MI dna VI rof elcsum ciretnahcortoili dna niev laihcarb thgir eht ni deretsinimda ... ngised latnemirepxE mutibil da doof eerf-lairetcabitna dna retaw ot ssecca nevig erew sehcirtso ehT nep metsys nepo detalosi na ni desuoh erew slamina ehT gurd eht gniretsinimda erofeb sngis lacinilc ... ytilibaliavaoib dna scitenikocamrahP .seiceps lamina rehto morf deniatbo erew nosirapmoc rof desu sCIM eht ,eroferehT sehcirtso ni smsinagroorcim elbitpecsus rof sCIM enilcycyxod eht no stroper on era...

Báo cáo khoa học: " Pharmacokinetics and biodistribution of Erufosine in nude mice implications for combination with radiotherapy" pot

... cell lines Our results constitute the basis for the design of preclinical investigations with Erufosine alone and in combination with radiotherapy in murine tumor models, in particular in nude mice ... Together with our earlier investigations on the increased cytotoxic efficacy of ionizing radiation in combination with Erufosine in glioblastoma cell lines in vitro, the ability of Erufosine to ... APC with antineoplastic activity, e.g Miltefosine, Perifosine, and Erufosine, induce apoptosis in tumor cells in vitro Depending on the cell type, the induction of apoptosis involves ligand-independent...

Báo cáo y học: "Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors" pps

... observed in of patients with RCC in this study confirmed the efficacy of everolimus in Chinese patients with RCC, consistent with experience from the larger phase III study in RCC [11] At the time of ... al.: Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors Journal of Hematology & Oncology 2011 4:3 ... phase I study was recommended by the China State Food and Drug Administration to evaluate PK, safety, and antitumor activity of oral everolimus and 10 mg/day in Chinese patients with advanced solid...

The situation of increasing serum uric acid, related factors and efficacy of dietary intake in over 30 year of age subjects in rural area of thai binh province

... EDUCATION AND TRAINING MINISTRY OF HEALTH NATIONAL INSTITUTE OF HYGIENE AND EPIDEMIOLOGY *************** PHAM THI DUNG THE SITUATION OF INCREASING SERUM URIC ACID, RELATED FACTORS AND EFFICACY OF DIETARY ... DISCUSSION 4.1 The increase in serum uric acid among people 30 years and older in rural communities in Thaibinh This study was conducted in a rural area of northern delta region in the context as the World ... serum uric acid levels in China, results showed that the rate of increase in serum uric acid was 21.6% in male and in female was 8.6% The risk of increased serum uric acid begins at age of 30 for...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays

... analytes, containing 1, and 10 nM of icariin, icaritin and desmethylicaritin; 5, 30 and 60 nM of icariside I and 71 icariside II, respectively and internal standard in pooled rat sera, were placed ... using lipofectamine Sixteen hours posttransfection, the cells were washed, trypsinized and split at ratio of in 10, in 100 and in 1000 into selective cell culture media containing 100 μg/mL of hygromycin ... fetal bovine serum and 10 μg/mL insulin in a humidified atmosphere of 5% carbon dioxide in air at 37°C 53 2.3 ERα and ERβ cell- based bioassays 2.3.1 Establishment of ERα and ERβ stable cells (from...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 2

... bioactivity of androgenic compounds in sera (Fig 26 F) 120 Figure 26 : Estrogenicity in serum following ingestion of estradiol valerate or Epimedium decoction Following baseline blood sampling (—▲—), ... (1.00-1. 12) 0.043 E2V 21 16 1.67 (1.58-1.77) ...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 4

... that of genistein and kaempferol (Maggiolini et al., 20 04; Leung et al., 20 04) The presence of serum reduced ERα binding of quercetin in MCF-7 cells, with relative binding affinities for genistein, ... effectiveness in sera of the decoction when administered orally Ingestion of a defined Epimedium decoction resulted in a 6% increase in ERα AUC effect over baseline in the subjects The increase in Epimedium ... group on ring B to interact with Glu-353 and Arg3 94 and another similar interaction involving the hydroxyl group on ring A with His-5 24 In contrast, for the case of icaritin, the interaction with...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 5

... ascertain whether the ingestion of estrogenic prenylflavonoids from Epimedium for the purpose of maintaining bone health can increase risk of ERα-positive breast cancer Interestingly, icaritin, ... and sulfatase Non-linear pharmacokinetics and prolonged effects for up to 72 h following administration of a single dose of Epimedium extract were also observed Coupled processes of enteric and ... endometrium and breast, the next step is to develop and validate a panel of such cell- based bioassays Even within the same cell line, differences exist in the ability of different compounds to induce estrogen- regulated...

Study of pharmacokinetics of prenylflavonoids and dynamics of estrogen action in sera following ingestion of epimedium using validated, ultra sensitive cell based bioassays 6

... P., Lee, L., Li, J and Yong, E.L 2009 Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract ... Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects Eur J Clin Nutr 61 (4):472-7 Klinge, C.M 2000 Estrogen receptor interaction ... of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats Mol Pharm 4 (6) : 865 -72 Mueller, S.O 2002 Overview of in vitro tools to assess the estrogenic and...

Clinical pharmacokinetics of tacrolimus in asian liver transplant patients

... 123 24 Final population PK model of Tac in Asian adult and paediatric liver transplant patients and its parameters 125 25 Final population PK model of Tac in Asian liver transplant patients ... relationships in Asian liver transplant patients between the PK of Tac and arthropometric characteristics of the patients, as well as the clinical conditions of the patients Using these models, in conjunction ... population PK of Tac in the local Asian adult and paediatric liver transplant recipients In the first study, the population pharmacokinetics (PK) of intravenous and oral Tac was determined in 20 Asian...

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