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Mechanism of protein quality control in the cytosol in budding yeast

Mechanism of protein quality control in the cytosol in budding yeast

Mechanism of protein quality control in the cytosol in budding yeast

... conserved cytosolic quality control pathways remains to be discovered The objective of this thesis is to get a better understanding of protein quality control in cytosol and further understand the mechanism ... al., 1998) The binding induces several factors; one of them being ubiquitin expression indicating its role in the regulation of the degradation system Under normal conditions, in the cytosol, HSF1 ... but it also assist in the folding of proteins through one or several ATPase cycle of binding and release and also promote the disaggregation of proteins with the help of another chaperone family...
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Regulation of mitotic spindle biogenesis in budding yeast

Regulation of mitotic spindle biogenesis in budding yeast

... the formation of a bipolar mitotic spindle Hence, understanding the regulation of mitotic spindle biogenesis, the subject of this dissertation, is crucial for gaining insights into the chromosome ... Chapter1 Introduction All spindles are bipolar, but the structure of the spindle pole differs in different organisms The spindle pole is pivotal to the biogenesis of the mitotic spindle In mammalian ... C-terminus of ubiquitin, forming a covalent thioester bond between the terminal glycine of ubiquitin (Gly76) with a cysteine in the active-site of E1 In the second step, an ubiquitin-conjugating...
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Protein folding quality control in the endoplasmic reticulum in

Protein folding quality control in the endoplasmic reticulum in

... ubiquitinate and degrade misfolded proteins in the ER With the final destination of misfolded proteins known, another question remained Although the ERQC substrates are detected and retained in the ... calnexin/calreticulin cycle Calnexin (CNX) is a type I transmembrane protein, while calreticulin (CRT) is a luminal protein, and together these two lectins act as the first stage of the ER quality control ... CHAPTER 1: Introduction 1.1 General introduction 1.1.1 Quality control in the cell 1.1.2 The secretory pathway 1.1.3 Quality control in the ER 1.1.4 Advantages for studying quality control in yeast...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf

Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf

... Bhagwat SV, Biswas G, Anandatheerthavarada HK, Addya S, Pandak W & Avadhani NG (199 9) Dual targeting property of the N-terminal signal sequence of P450 1A1 Targeting of heterologous proteins to ... open N-terminal signal domain is critical for protein targeting to the ER (Fig 2D) In contrast to the targeting of CYP 1A1 requiring N-terminal truncation, we have shown that intact CYP2B1 and CYP2E1 ... that xenobiotic-inducible CYPs such as rat CYP 1A1 , CYP2E1 and CYP2B1, and mouse CYP 1A1 , contain chimeric noncanonical -targeting signals that are capable of targeting proteins to both the ER and...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx

Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx

... well as NO production Accordingly, we concluded that the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives ... amphiphilic structure of the polar carboxyl moiety and the hydrophobic isoprene moiety The enhancing effect of TS on LPS/IFN -induced NO production was inhibited by the coexistence of a-T, TA and TN ... the VSMC, but TS was not hydrolyzed to a-T and succinic acid [32] Accordingly, the enhancement of LPS/IFN -induced NO production is attained by TS itself rather than a derivative TS enhanced LPS-dependent...
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Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf

Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf

... with the patterns of binding of Nrl to the rhodopsin promoter (Fig 4C,D) The mRNA transcript levels of Ppp2r5c and rhodopsin in mouse retina corresponded to the observed increase in Nrl binding ... Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A Science 283, 2089–2091 16 Li X, Yost HJ, Virshup DM & Seeling JM (2001) Protein phosphatase 2A and its B56 regulatory subunit ... transcriptional activity of the NRL [23] Nrl interacts with cone-rod homeobox [24], Flt-3-interacting zinc-finger [25] and TATA box-binding protein [26] to regulate the expression of rhodopsin [27], NR2E3...
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Báo cáo khoa học: Modulation of the Arabidopsis KAT1 channel by an activator of protein kinase C in Xenopus laevis oocytes potx

Báo cáo khoa học: Modulation of the Arabidopsis KAT1 channel by an activator of protein kinase C in Xenopus laevis oocytes potx

... calcium-activated K+ channel, large-conductance Ca2+and voltage-regulated K+ channel, hyperpolarizationactivated cyclic nucleotide gated channel, ether-a-go-go and cyclic nucleotide-gated channel ... sites at the cytosolic face of KAT1 (B) Changes in the current amplitudes of the different KAT1 mutants after PMA application The characteristics of WT KAT1 in the presence and absence of PMA are ... a PKC homolog, which can be detected with the PKC antibody in Brassica juncea, is activated by PMA and inhibited by the general kinase inhibitor H-7 and the PKC-speci c inhibitor staurosporine...
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Báo cáo khoa học: Structural determinants of protein stabilization by solutes The importance of the hairpin loop in rubredoxins pdf

Báo cáo khoa học: Structural determinants of protein stabilization by solutes The importance of the hairpin loop in rubredoxins pdf

... maze of interactions and try to rationalize them is to investigate series of homologous proteins in order to unravel the structural determinants of protein stabilization by compatible solutes In ... reduced in the presence of DGP It is also interesting to note that, for the point mutants, the added stabilization follows the intrinsic stability, with the larger increases occurring in the proteins ... throughout the protein structure Stabilization by compatible solutes To obtain insight into the mode of action of compatible solutes, we examined the impact of several mutations of RdDg on the degree of...
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Báo cáo khoa học: Residues near the N-terminus of protein B control autocatalytic proteolysis and the activity of soluble methane mono-oxygenase doc

Báo cáo khoa học: Residues near the N-terminus of protein B control autocatalytic proteolysis and the activity of soluble methane mono-oxygenase doc

... SDS/PAGE and electrospray ionization (ESI)-MS Incubation of < /b> the < /b> purified protein < /b> B/ B¢ mix at 20 °C for 1–2 days enabled complete conversion of < /b> protein < /b> B to B Separation of < /b> proteins B and B by chromatofocusing ... calculated masses of < /b> proteins B, B and B ¢ On chromatofocusing the < /b> sample could be readily resolved into proteins B, B and B ¢ Immediate SDS/ PAGE analysis of < /b> the < /b> protein < /b> B fraction at this ... active protein < /b> B was then subjected to further rounds of < /b> chromatofocusing, and on each occasion the < /b> protein < /b> was resolved into B and B During these operations, the < /b> highly purified protein < /b> B was observed...
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Experiences in Quality Control in the Audit Process and Audit Quality docx

Experiences in Quality Control in the Audit Process and Audit Quality docx

... templates and auditing software • Quality Control in the Audit Process – Integrity, due care, professional behaviour – Clear responsibilities (who will the work and who will review) – Review and consultation ... review (before issuing an auditor’s report) Formation and training of quality assurance team and starting that process Certification of auditors (minimum requirement on audit manager and head of department ... our audits to international auditing standards and best practise of others SAI-s We have reviewed our audit process During the review we listed our process steps and necessary document templates...
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Cocoa Processing Methods for the Production of High Quality Cocoa in Vietnam ppt

Cocoa Processing Methods for the Production of High Quality Cocoa in Vietnam ppt

... with the Vietnamese research Institutes involved Success Alliance is also thanked for their assistance in providing information regarding the cocoa industry in Vietnam and in the establishment of ... darken in colour during drying as the majority of browning reactions will occur during this process DRYING OF COCOA Drying of cocoa is an important step in cocoa processing as some of the reactions ... get air into the fermenting cocoa and to help make the fermentation even throughout the cocoa When more air gets into the cocoa, as a result of turning, the rate of fermentation will increase...
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assess the efficiency of dental plaque control in decay teeth, gingivitis prevention for the 12 years- old pupils at some schools in the suburb of hanoi

assess the efficiency of dental plaque control in decay teeth, gingivitis prevention for the 12 years- old pupils at some schools in the suburb of hanoi

... factors relating to the decay teeth, Gingivitis, dental plaque and KAP about ODC for the 12 year -old pupils - Identified the reality of the decay teeth, gingivitis, dental plaque for the pupils - ... about the oral and dental care for the 12 years -old pupils at some secondary schools in Gia Lam, Quoc Oai District, Hanoi City in 2009 Assess the efficiency of dental plaque control in the decay teeth, ... activities in Hanoi in 2009-2010 of National Institute of Othodonto – Stomatology”, we researched the theme: Assess the efficiency of dental plaque control in decay teeth, gingivitis prevention for the...
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Quality Assurance and Quality Control in the In Vitro Fertilization Laboratory pdf

Quality Assurance and Quality Control in the In Vitro Fertilization Laboratory pdf

... IVF Laboratory There are several advantages of employing QA and QC schemes in the established IVF laboratory These include ensuring optimal laboratory performance is consistent and maintained Their ... accuracy Table Internal Quality Control Measures Used to Assess the Performance of New Equipment Installed in the Assisted Conception Quality Assurance and Quality Control in the IVF Laboratory 369 ... occasions, the water tested negative following sanitization Quality Assurance and Quality Control in the IVF Laboratory 371 Figure Temperature recordings from three incubators newly installed in the...
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Báo cáo y học:

Báo cáo y học: "Understanding uptake of continuous quality improvement in Indigenous primary health care: lessons from a multi-site case study of the Audit and Best Practice for Chronic Disease project" ppt

... article as: Gardner et al., Understanding uptake of continuous quality improvement in Indigenous primary health care: lessons from a multi-site case study of the Audit and Best Practice for Chronic ... mitigate against the successful uptake of innovations like ABCD High among these was the turnover and shortage of staff in many Indigenous primary health care services, and in remote areas the additional ... objective information to analyse and improve systems and service delivery [7] Participating services use annual quality improvement cycles (plan-do -study- act) and a set of clinical audit and system assessment...
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