Posttranscriptional regulation of erythropoiesis by RNA binding proteins and microRNAs

... Primary miRNAs are transcribed and processed by Drosha and DGCR8 to form pre-miRNAs pre-miRNAs are transported out of nucleus by RAN-GTP and Exportin-5 and further processed by Dicer and loaded ... are shown32 5.6 microRNAs in erythropoiesis microRNAs are a class of small non-coding RNAs involved in the regulation of many biological processes through the downregulation of multiple target ... POSTTRANSCRIPTIONAL REGULATON OF ERYTHROPOIESIS BY RNA- BINDING PROTEINS AND MICRORNAS LINGBO ZHANG (M.S., Tsinghua University; B.E., Tianjin University) A THESIS SUBMITTED FOR THE DEGREE OF...

Báo cáo y học: "Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response" ppt

... is in accordance with the highly increased cytokine and chemokine secretion induced by poly(I:C) and emphasizes the strong proinflammatory impact of the TLR3 ligand poly(I:C) for SAEC Regulation ... expression of other TLRs and proteins involved in TLR signaling in SAEC In addition, we demonstrate that the expression of TLRs and their signaling proteins in SAEC is strongly regulated by type-1 and ... release of inflammatory mediators The family of Toll-like receptors (TLR) plays a key role in pathogen recognition and induction and regulation of the innate and adaptive immune response Airway epithelial...

Regulation of sla2p by activity in endocytosis and actin organization by the ark1 prk1 family of kinases

... phosphorylation by Prk1p and possibly Ark1p kinase These kinases constitute a unique family of actin regulating kinase whose substrates include many components of actin machinery as well as endocytic and ... depolymerization Actin bundling proteins such as Sac6p and Abp140p can be found coating the actin cables, and bind actin filaments together to form a cable The exact mechanism and the regulation of their ... structures: actin patches at cell cortex, actin cables running along the long axis of the cell, and the acto-myosin ring at the bud neck (Moseley and Goode, 2006) Since then, the interest in yeast...

Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the speciﬁcity and relative binding energy of RNA-binding proteins ppt

... discrimination We anticipate that the performance of the potential will only increase with the size of the structural database and as terms are added to the model to account for protein and RNA intra-molecular ... structural data available for training Nevertheless, the distancedependent potential function already performs on par with the amber and rosetta force ﬁelds in decoy discrimination tests The impact of ... less favorable statistics (fewer structures of protein–RNA complexes) We anticipate that the increasing availability of protein– RNA structures, together with the availability of data on speciﬁcity, ...

Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx

... shown) Inhibition of pneumococcal murein hydrolases by bicyclic amines As shown above, tropic esters of bicyclic amines were selected and characterized by biophysical methods as strong ligands ... that the bicyclic amines are also able to bind to the active site of Pce Effect of choline analogs on cell growth and viability Fig Effect of choline and analogs on the activity of cell wall ... by CD Fig Spectroscopic analysis of ligand binding to C-LytA (A) Conformational changes induced by ligands on C-LytA monitored by near-UV CD with no ligand added (—) and upon addition of ligands:...

Báo cáo Y học: Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction ppt

... anchoring by E coli PBPs 4, 5, and 6b (Eur J Biochem 269 ) 5827 Fig Helical wheel representations of protein segments The C-terminal sequences of PBP4, PBP5, PBP6 and PBP6b, and the primary sequence of ... 0 .65 0.23 Ó FEBS 2002 Membrane anchoring by E coli PBPs 4, 5, and 6b (Eur J Biochem 269 ) 5823 The peptides P4 and P5 (Table 1) were supplied by PEPSYN, University of Liverpool, UK, produced by ... phase ﬂuidity and a decrease in liquid crystalline phase ﬂuidity (C) Here, we analyzed the C-terminal sequences of PBP4, PBP5, PBP6 and PBP6b to identify candidates with the potential to form oblique...

Báo cáo y học: "Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins" ppsx

... Defining potentially conserved RNA regulons of homologous zinc-finger RNA- binding proteins Genome Biology 2011 12:R3 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... intron of ZNF9 cause myotonic dystrophy type (DM2) DM2 is characterized by heterogeneous, multi-systemic symptoms, including myotonia [29] The disease is thought to be caused by RNA gain -of- function ... coordinated by RBPs In the future, this approach may be used to decipher the structure and plasticity of RNA regulons met by RBPs in a wide range of species, following reactions of internal and external...

báo cáo khoa học: " The Puf family of RNA-binding proteins in plants: phylogeny, structural modeling, activity and subcellular localization" potx

... analysis of the amino acids located in the amino-terminal extensions that lie outside of the PUM-HD in AtPum proteins A comparison of the percentage of amino acid identity and similarity for the amino ... resulting in an amino acid triplet that matches that of Puf repeats and in the conserved proteins Interestingly, this CRQ triplet is also found in repeat in some fungal and protozoan Puf proteins ... 1000 nM and 2000 nM samples, indicating that the low affinity binding of the AtPum-HD to the RNA resulted in a dissociation of the complex during electrophoresis Thus, the instability of the complex...

Báo cáo y học: " Regulation of primate lentiviral RNA dimerization by structural entrapment" ppt

... hours of culture [52], the majority of their genomic RNAs may have been matured by slow-acting dimerization site(s), which may explain why most of their SL1 mutations were phenotypically silent ... entrapment may have twin roles in the regulation of lentiviral leader RNA dimerization since promoting SL1 presentation by increasing its folding stability (Table 3) may favor the formation of SL1 ... SL1-mediated tight dimerization of three primate lentiviral RNAs can be regulated by a specific short-range (stem B) interaction and by a long-range interaction involving the 3' end of the leader RNA through...

Báo cáo y học: " Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication" potx

... box proteins may have roles in maintaining HIV latency If this reasoning is correct, then the selective targeting of such DEAD box factors might offer another means of ending HIV latency and ... activity were also up regulated during this period, including the methylated mRNA cap binding proteins EIF4G1 [27] and NCBP1 (CBP80) [28], which function in translation initiation and may also be involved ... important in elucidating Rev function and viral RNA export, as well as the synthesis of viral proteins While some of the differentially expressed DEAD box proteins, beyond DDX1 and DDX3, may play a...

Báo cáo khoa học: Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis pot

... comprehensive proteomics analysis of 14-3-3-binding proteins under physiological conditions as compared with apoptosis stimulation, with the aim of increasing our knowledge of the role of 14-3-3 proteins ... changes in 14-3-3-binding patterns in HeLa cells during C2-ceramideinduced apoptosis With the aim of further analyzing the role of 14-3-3 proteins in apoptosis, an evaluation of the ability of proteins ... role of 14-3-3 proteins in C2-ceramide-induced apoptosis, probably through regulation of already known apoptosis- related 14-3-3-binding proteins, some of them most likely still to be identiﬁed 14-3-3-binding...

Báo cáo Y học: Transcriptional regulation of erythropoiesis Fine tuning of combinatorial multi-domain elements ppt

... myeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells Sixty percent of polycytemia vera patients have diminished expression of SHP-1 in CFU-E populations ... Ó FEBS 2002 Transcriptional regulation of erythropoiesis (Eur J Biochem 269) 3615 of these key transcriptional regulators of the erythropoietic process and notes at least part of their multi-element ... Acetylcholinesterase, a potential hematopoiesis/ erythropoiesis regulator A case study for a downstream regulator may be that of acetylcholinesterase (AChE) Primarily known to hydrolyze acetylcholine...

Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt

... 6075 p53, p73 and HIPK2 in apoptosis N Bitomsky & T G Hofmann Fig Regulation of DNA damage- induced cell death by p53 and HIPK2 Genotoxic stress-induced DNA damage facilitates activation of the DNA ... (2009) 607 4–6 083 ª 2009 The Authors Journal compilation ª 2009 FEBS N Bitomsky & T G Hofmann p53, p73 and HIPK2 in apoptosis Fig Regulation of DNA damage- induced cell death by the p73 pathway ... apoptotic p53, p73 and HIPK2 in apoptosis signalling routes of the DDR regulated mainly from the cell nucleus and the key molecules p53, p73 and homeodomain-interacting protein kinase (HIPK2) Multiple...

Báo cáo khoa học: Regulation of secretases by all-trans-retinoic acid pot

... levels is mainly achieved by modulation of secretases, namely by the induction of a-secretase activity, by inhibition of b -secretases and ⁄ or c -secretases, or by a combination of both This study provided ... Regulation of secretases by retinoic acid A Koryakina et al use of several potential PKC activators, such as phorbol esters Therefore, an assessment of the action of RA(s) in AD ... FEBS 2647 Regulation of secretases by retinoic acid A A Koryakina et al B Fig ATRA treatment activated PKCs and caused increased secretion of sAPPa in IMR-32 cells (A) Phosphorylation of PKC was...

Báo cáo khoa học: Regulation of DNp63a by tumor necrosis factor-a in epithelial homeostasis docx

... of DNp63a by TNF-a was attenuated by inhibition of NF-jB, suggesting that activation of NF-jB may be involved in the regulation of the degradation of DNp63a Interestingly, knockdown of DNp63a expression ... function of DNp63a for epidermal stem cell proliferation, we were interested to know whether factors involved in maintaining epidermal homeostasis affect DNp63a expression We were particularly interested ... signaling cascade TNFRI can also activate other signaling cascades, including the JNK pathway To determine whether NF-jB or JNK signaling is involved in the degradation of DNp63a, we utilized inhibitors...

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