... responsible for the pilot study, participated in the design of the trial and was responsible for coordination of trial activities and trial procedures RN conceived of the study, participated in the trial ... investigator-initiated, randomized, multi-center, double-blind, parallel-group, placebo-controlled, phase clinical trial It focused on the potential of Swedish snus to reduce smoking and increase quit ... chemical composition of snus, the epidemiology of snus use in Sweden, health effects of nicotine and snus versus cigarette smoking, how to use the study products, the need for adequate nicotine...