Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
... 11 3 6 .1. 4 Mutagenesis 11 3 6 .1. 5 6.2 HCT 116 and E1 cell lines 11 2 Transfection 11 4 Cell-based assays 11 5 6.2 .1 6.2.2 Wound healing 11 5 6.2.3 ... Stathmin- 1 1. 2 .1 The Stathmin family 1. 2.2 STMN1 in microtubule regulation 10 1. 2.3 STMN1 in cell cycle regulation 12 1. 2.4 STMN1 in cancer 14 ... Conclusion and future work 10 7 Chapter Materials and methods 11 0 6 .1 Cell lines and constructs 11 2 6 .1. 1 6 .1. 2 Preparation of whole cell lysate 11 2 6 .1. 3 STMN1 KD and...
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Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot
... the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α in the presence of interleukin-1β ... the work by Yudoh and colleagues adds further experimental evidence for the suggested role of HIF-1 in protecting chondrocytes from cell death induced by pro-inflammatory cytokines Finally, Yudoh ... HIF-1 is of pivotal importance in cartilage development and homeostasis Furthermore, given the decreased oxygen levels and presence of inflammatory mediators during the course of OA, a causal role...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... staining for phenotypic markers in chondrocyte-like cells from human intervertebral discs Immunohistochemical staining for collagen phenotypic markers in chondrocyte-like cells from human intervertebral ... Suda A: Cathepsin G in degenerating and healthy discal tissue Clin Exp Rheumatol 1999, 17:197-204 Gruber HE, Hanley EN Jr: Analysis of aging and degeneration of the human intervertebral disc Comparison ... every other day Assessment of re-differentiated state in alginate To ensure that the phenotype of cells treated with IL-1 were similar to the phenotype of cells within the IVDs in vivo, the cell...
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báo cáo khoa học: " Overexpression of Pim-1 in bladder cancer" pdf
... understand of the clinical significance of Pim-1 Figure Expression profile of Pim-1 in bladder cancer cell lines A Expression profile of Pim-1 in bladder cancer cell lines Cell lysate from five bladder ... Pim-1 in bladder cancer cell lines In order to further demonstrate the role and function of Pim-1 in bladder cancer, the expression level of Pim-1 was validated in bladder cancer cell lines using ... further classified into Noninvasive (Tis, Ta and T1) and invasive (≥T2) groups The data (Table 2) shows that the staining intensity of Pim-1 is increased in invasive bladder carcinoma samples (95%)...
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báo cáo khoa học: "T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer" pps
... although analyses of T cell subsets in the lymph nodes of breast cancer patients have been performed [20], the effect of these T cell subsets on colorectal cancer patient outcome had not been explored ... were included in this study Stage II patients were chosen because they have no tumour metastases in lymph nodes The number of lymph nodes retrieved from patients for staging is indicated in Table ... 20 Page of 20 10 10 0 recurring non recurring patient outcome control recurring non recurring control patient outcome Figure No association between CD4+ or CD8+ cells and patient outcome Between...
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Báo cáo y học: " The role of endothelin-1 in hyperoxia-induced lung injury in mice" docx
... demonstrate the presence of such opposite changes in the responsiveness of the airway and tissue compartments in the presence of oxygen toxicity Indeed, expression of the hyperoxia-induced changes in the ... in larger mammals [9,45] and in mice [46] Conclusion In summary, the results of the present study yield evidence of the involvement of ET-1 in the lung function changes induced by hyperoxia The ... stimuli In fact, the apparent hyperreactivity of the lung is attributed to the presence of the enhanced responsiveness of the lung parenchyma and not to the elevated reactivity of the airways As...
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Báo cáo y học: " Role of endothelin-1 in lung disease" potx
... injury by inducing expression of cytokines including tumor necrosis factor and IL-6 and IL-8 [149] These cytokines may in turn stimulate the production of many inflammatory mediators, leading to lung ... synthase in the lung [148] ARDS is also characterized by the presence of inflammatory cells in the lung Since ET-1 may act as an immune modulator, an increase in ET-1 may contribute to lung injury ... medial layer of the arteries, decreasing in intensity in the peripheral circulation [84,85] ETB receptors are also found in the media of the pulmonary vessels, increasing in intensity in the distal...
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CHARACTERIZING ROLES OF ANNEXIN 1 IN BREAST CANCER DEVELOPMENT BY MASS SPECTROMETRY BASED QUANTITATIVE PROTEOMICS
... tagging for relative and absolute quantification IAA Iodoacetamide ICAT Isotope-coded affinity tagging K0R0 12 C 614 N2-lysine and 12 C 614 N4-arginine K8R10 13 C 615 N2-lysine and 13 C 615 N4-arginine ... Annexin 1. 2 .1: Structure of ANXA1 ANXA1 is one of the members of the annexin superfamily of 13 members (A1-A13) All members of this superfamily have the same principal property of binding to negatively-charged ... System, Singapore on 30 January 2 013 This work was presented as a poster in Proteomics Forum held in Berlin, Germany from 17 – 21 March 2 013 xvii Chapter 1: Introduction 1. 1: Breast cancer Breast cancer...
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Elucidation of the physiologic role of TRIP br2 in cell cycle regulation and cancer pathogenesis
... 2000) CDK protein levels remain stable during the cell cycle, in sharp contrast to their activating proteins, the cyclins The oscillatory expression of most cyclin proteins during cell cycle progression ... C-terminus of TRIP- Br2, which includes the putative C-terminal NES of TRIP- Br2, stabilized TRIP- Br2 in G2/M phase 189 Figure 30E Inhibition of nuclear export of TRIP- Br2 by LMB restores its stability in ... include the cyclin-dependent kinases (CDKs), a family of serine/threonine protein kinases that are activated at specific points of the cell cycle To date, nine CDKs have been identified and, of these,...
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THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
... 11 6 11 9 4 .1 The role of Annexin- 1 in the regulation of inflammatory stress 11 9 response 4.2 Conclusion 14 4 4.3 Limitations of the study 14 5 4.4 Future work 14 6 Bibliography 14 8 Summary Annexin- 1 ... for investigation of the basis of the inflammatory stress response The aims of this study are thus, 1) To determine the role of ANXA1 in the regulation of the inflammatory response upon induction ... (ANXA1) 27 1. 6 .1 Functions of ANXA1 29 1. 6 .1. 1 ANXA1 in inflammation 29 1. 6 .1. 2 ANXA1 in cellular proliferation, differentiation and apoptosis 31 1.6 .1. 3 ANXA1 in cancer 33 1. 6 .1. 4 ANXA1 in leukocyte...
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The role of prion protein in breast cancer cell metabolism
... of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer metabolism ... higher in normal breast cell line (MCF10A) than breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast cancer cell lines Up-regulation of p53 in breast cancer cell lines ... highest in terms of mortality rate (WHO, 2008), while according to the Singapore Cancer Registry, in 17 women will develop breast cancer in her lifetime in Singapore The risk of getting breast cancer...
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The role of caspase 1 in a murine model of influenza pneumonitis, and studies on cell death inhibitors in vitro
... function upstream of the effector caspases in apoptosis and are known as initiator caspases A phylogenetically distinct group of 13 caspases (caspase- 1, caspase- 4, caspase- 5, caspase- 11 and caspase- 12 ) ... caspase- 1 to an influenza A/ Puerto Rico/8/34 (H1N1) virus infection of RAW264.7 murine macrophages, in vitro To investigate the role of caspase- 1 in pulmonary inflammation and cell death and its contribution ... known as PYCARD, which consists of an N-terminal PYD domain and a C-terminal caspase activation and recruitment domain (CARD) that is necessary for the binding of caspase- 1 to the inflammasome (Martinon...
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Báo cáo y học: " The role of γδ T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice" pps
... attenuated in the γδ T cell deficient mice Our findings are consistent with a role of γδ T cells in determining the magnitude of the inflammatory response to acute epithelial injury and in maintaining ... hyperresponsiveness and exhibit an attenuated inflammatory response The contribution of γδ T cells to epithelial regeneration in the intestine is not evident in the airways Competing interests The author(s) ... single exposure to chlorine We hypothesized that γδ T- cells were involved in modulating airway responses to methacholine and the repair of airway epithelium after acute chlorine gas exposure The γδ...
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the role of fgfr3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice
... The role of FGFR3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice Mona Foth Submitted in fulfilment of the requirements for the Degree of PhD ... at the signalling downstream Thirdly, we examined the role of the most common mutation in FGFR3, S249C, in the urothelium and in tumour progression and invasion by subjecting Fgfr3 mutant mice ... signalling in the early stages of non-invasive urothelial carcinoma as well as in tumour progression of established neoplasms in mice Given the wide availability of inhibitors specific to FGF signalling,...
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Dual functions of AP 1 in neuronal cell death and differentiation
... of c-Jun, c-Fos and ATF2 29 1. 3 .1. 3 Regulation of AP- 1 activity by its interacting proteins 30 1. 3.2 Role of AP- 1 in cell proliferation and differentiation 31 1.3.2 .1 Role of AP- 1 in ... AP- 1 in cell proliferation 31 1.3.2 .1. 1 AP- 1 is an important regulator in cell proliferation 31 1.3.2 .1. 2 Mechanisms of AP- 1 modulation of cell proliferation 33 1. 3.2 .1. 3 AP- 1 is a ... cyclin D1 p16 p 21 JunD G1 S G2 M G0 Fig 1. 12 Effects of AP- 1 proteins on cell cycle regulation AP- 1 proteins control cell cycle progression by regulating the expression of key components of the cell...
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