The androgen receptor centric transcriptional network in prostate cancer

... is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... limited number of cytokines that inhibit the adhesiveness, growth and migration of cancer cells The most intriguing finding of the present study was that the function of MDA-7 in prostate cancer ... Cite this article as: Ablin et al.: Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer Journal of Translational Medicine 2011 9:49 Submit your...

... substantial loss in nicotinic receptors in cortex and striatum According to the growing amount of findings, accumulation of amyloid plaques which are the baseline indicator in the brain for AD is interfered ... in response to acute nicotine exposure It furthermore suggests the strong synchronization of hippocampal neural network in the mid phase (gamma oscillation segment) in response to acute nicotine ... needed in these cases [24] In the current study, we have investigated the effect of nicotine on the complexity of the neurons and the activity of the gamma oscillations in the Schaffer CA1 cell line...

... is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... limited number of cytokines that inhibit the adhesiveness, growth and migration of cancer cells The most intriguing finding of the present study was that the function of MDA-7 in prostate cancer ... Cite this article as: Ablin et al.: Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer Journal of Translational Medicine 2011 9:49 Submit your...

... analyzed whether treatment with the Akt-inhibitor ErPC3 would increase the short- time antineoplastic effects of ionizing radiation in the prostate cancer cell lines Combined treatment with ErPC3 and ... reduced the number of viable LNCaP, PC3 and DU145 cells as determined by the WST-1 test In PC3 and DU145 cells the antineoplastic effects of the combination treatment could mainly be attributed to the ... in the levels of Bcl-2 in both cell lines Moreover, ErPC3treatment decreased the levels of Mcl-1 in LNCaP cells Thus, in LNCaP cells the down-regulation of the two anti -apoptotic Bcl-2 proteins...

... Artificial neural networks (ANNs) are attractive analytical tools in medicine due to their ability to learn from historical examples, analyze non-linear data and being able to generalize a model to independent ... in a preclinical study in prostate cancer xenografts, and suggest that the combination of functional MRI parameters, in addition to standard clinical parameters, increases the power of predicting ... be to apply the same approach in a clinical setting, including parameters from functional MRI, as well as standard clinical parameters, from PCa patients receiving ADT and/ or RT treatment In...

... article as: Vranova et al.: The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques Radiation ... and GU toxicity observed in patients during their last inspection are shown In the cohort of patients included in the WP group, pretreatment GI toxicity of grade was found in the history of patients ... Sonmez S, Yavuz A: Comparison of rectal volume definition techniques and their influence on rectal toxicity in patients with prostate cancer treated with 3D conformal radiotherapy: a dose-volume...

... http://www.ro-journal.com/content/6/1/123 Page of 11 Figure Example of the contouring of the penile bulb, based on the guidelines suggested by the steering committee The projection of the PB contour on the more ... imaging technique for most radiotherapy Institutes where access to MRI for planning is still lacking Although the well documented limitation of CT images in the delineation of the penile bulb ... assess inter-observer variation in contouring PB on CT images, as this technique still represents the routine practice for most institutes in Europe, although the use of MRI for prostate planning...

... during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression of cell cycle controlling ... with genistein 10 μM and irradiation with Gy together, the effects of genistein on survival in these cell lines seem to be independent of ER- and p53-expression In contrast, low concentrations of ... after incubation with genistein concentrations of 15 – 30 μM in FCS-containing media [41] In this study the NF-κB activity was investigated, too An inhibition of radiationinduced activation of NF-κB...

... To our Figure Inhibition of trypsin-induced cyclooxidase-2 (COX-2) expression by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in human synoviosarcoma cells Human synoviosarcoma ... Inhibition of trypsin-induced nuclear factor (NF)-B activation by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in synovial cells Human primary synovial cells or synoviosarcoma ... study showed higher expression levels of PAR-2 in human primary synovial cells than in chondrocytes [12] However, the role of PAR-2 in synovial cells has not been well investigated Therefore in the...

... virus- receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody Retrovirology 2010, 7:38 Page 13 of 13 ... the virus- receptor interaction may not simply be a modulation of binding affinity, rather it could represent a shift in the way the Env and receptor interact The two modes of interaction may be ... derived in vivo escaped neutralising antibody by the acquisition of mutations in the V5 loop region We therefore generated chimaeric envs in which a fragment encompassing the V4 and V5 loops of the...

... association of XMRV infection with higher grade tumors [7] Contrary to the initial study, Singh’s study found viral antigen-positive cells primarily in malignant prostatic epithelium, independently of the ... out of 201 non-PCa (Figure 4D) sera marginally reduced the XMRV infectivity (over 80% block of XMRV infectivity at a 10-fold dilution) However, by Western blot probing cell lysates from XMRV- infected ... below the flow data, respectively The percent neutralization was calculated as the reciprocal of infectivity, with a maximum infectivity being determined by incubation of the virus with an uninfected...