Functional role of low density lipoprotein receptor related protein 5 and 6 in alzheimers disease
Functional role of low density lipoprotein receptor related protein 5 and 6 in alzheimers disease
... through binding to low- density lipoprotein receptor- related protein 5/ 6 in SH-SY5Y cells Manuscript in preparation Zhang L, Bahety P, Ee PL Protective role of Wnt signaling co-receptors LRP5 /6 against ... APOLIPOPROTEIN E4 DISRUPTS NORMAL MITOCHONDRIAL DYNAMICS THROUGH BINDING TO LOWDENSITY LIPOPROTEIN RECEPTOR- RELATED PROTEIN 5/ 6 IN SHSY5Y CELLS 75 5....
Báo cáo y học: "Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases" pps
... available on the autoimmunity to LRP2 in humans Therefore, we have investigated the autoimmunity to LRP2 in systemic autoimmune diseases, focusing on prevalence, autoepitope distribution, clinical significance, ... Tohma S, Inoue T, Yamamoto K, Nishioka K, Kato T: Autoantibodies to T cell costimulatory molecules in systemic autoimmune diseases J Immunol 1999, 1 62: 4 328 -...
Báo cáo khoa học: Binding areas of urokinase-type plasminogen activator– plasminogen activator inhibitor-1 complex for endocytosis receptors of the low-density lipoprotein receptor family, determined by site-directed mutagenesis doc
... bound 64 10% of all complexes, and the binding of variant complexes always varied less than 20% from the binding of the wild-type complex Binding of the uPAPAI-1 complex to the receptors was ... between the uPA PAI-1 complex and the endocytosis receptors In the model of the complex between PAI-1 and the uPA SPD, constructed from the 3D struc...
Báo cáo y học: "Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats" potx
... Landsberger et al.: Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats Critical ... lipoprotein receptor-1 resulted in a reduction of endotoxininduced intestinal leukocyte adhesion Therefore, this receptor may represent a nove...
Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
... resulting in the accumulation of both unmodified cholesteryl esters and glycated apoB in the cells The rate of removal of the latter species is slow, with only 20–30% of the glycated protein being ... although the concentrations of these materials present in the artery wall, and in atherosclerotic lesions, are unknown The role of glycation and...
Báo cáo khoa học: Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats ppt
... controls Protective effect of dietary curcumin, capsaicin and their combination on iron -induced LDL oxidation in vivo and copper -induced LDL oxidation in vitro Oxidation of LDL observed in iron(II) ... Manjunatha and K Srinivasan Protective effect of dietary curcumin, capsaicin and their combination on iron -induced LDL oxidation in viv...
Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf
... further investigate the role of the SEA domain in cleavage of membrane-tethered mucins we carried out site-directed mutagenesis of the FRPG ⁄ SVVV site and evaluated hybrid mucins in which the SEA ... previously The fragments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR The remaining portions of the polylinker intr...
Báo cáo khoa học: Functional analysis of two divalent metal-dependent regulatory genes dmdR1 and dmdR2 in Streptomyces coelicolor and proteome changes in deletion mutants ppt
... regulators in S coelicolor Fig Comparative alignment of domains (DNA–protein interaction), (dimerization and metal binding) and (containing a nonconserved amino acid stretch), of the Streptomyces coelicolor ... on DNAÆprotein interaction and of domain in the protein dimerization and metal binding (see the Discussion) There are important differences between DmdR1 and...
Báo cáo khoa học: Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis doc
... portfolio of cell ECM interaction assays indicated roles for DP9 in cell adhesion, in vitro wound healing, cell migration and apoptosis, and for DP8 in wound healing, cell migration and apoptosis enhancement ... be to retain expressing cells in the tumor and in sites of expression in the injured liver It would be interesting to localize the D...
Báo cáo khoa học: " An Investigation of the Ability of the Glutaraldehyde Test to Distinguish between Acute and Chronic Inflammatory Disease in Horses" ppsx
... of the reliability of the glutaraldehyde test to determine the level of gamma globulin in the serum of foals and the suitability of this test in practice for the control of colostrum intake in ... adding equal amounts of fresh blood and glutaraldehyde in a test tube, mixing by slowly turning the test tube and visually observing and not...
Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx
... half-time for binding to the Characterization of the binding of PCSK9 to intact cells Fig Nonlinear regression and Scatchard analyses of binding- inhibition data (A) Inhibition of [125I]TC-PCSK9 (2.5 ... binding to HepG2 cells To determine whether the kinetics of binding of PCSK9 to HepG2 cells can be described as a simple bimolecular reaction, the...
Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... FNIII domains of gp130 are therefore assumed to be arranged in such a way that the C-terminal parts of the membrane-proximal domain D6 are positioned in close vicinity to each other In analogy, ... correct spacing and orientation of the cytoplasmic parts of the receptors for signalling An exchange of gp130 D6 with a domain that does not allow interactions...
Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf
... endomorphins on huLDL oxidation Table Kinetic parameters for the Cu2+-induced peroxidation of LDL and its inhibition by endomorphins and GSH The reaction conditions and the initial concentration of the ... the control the inhibition period the rate of the absorbance increase became faster, which is close to the original rate of propagation, demonstrating the ex...
Báo cáo khoa học: Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation Quercetin as an effective antioxidant against pro-oxidant effects of urate potx
... also be involved in the pro-oxidant action of urate Interestingly, at high Cu2+ concentration, in the presence of 0.5 lM quercetin and 10 lM urate, the LDL oxidation measured in terms of MDA and ... suppose that in the absence of quercetin the prooxidant activity of urate masks its antioxidant activity as mentioned above, whereas, in the presence of...
Báo cáo Y học: Anti- and pro-oxidant effects of urate in copper-induced low-density lipoprotein oxidation pdf
... study [57], the already observed pro-oxidant activity of urate [58] It is unlikely that the pro-oxidant activity of urate is due to the reaction of urate with O2 , as little urate is destroyed in ... relating Cu2+ redox change to the initiation of LPO in LDL are not yet clearly established [40] In the presence of pre-existing traces of hydroperoxides both Cu2+ a...
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