... degeneration there is a change in cell phenotype resulting in decreased matrix production, particularly proteoglycan synthesis, and an increase in degradation of IVD matrix by locally produced matrix ... de-stabilisation of the motion segment and the ingrowth of blood vessels and nerves resulting in generation of Here we demonstrate the synthesis and localisation of CDMP and CDMP within human IVDs ... Stimulation of mature canine intervertebral disc by growth factors Spine 1991, 16:253-260 Li J, Yoon ST, Hutton WC: Effect of bone morphogenetic protein- 2 (BMP-2) on matrix production, other BMPs, and...