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Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx

Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx

... on the 3Â-end processing step (not shown) The effect of peptides on the strand-transfer reaction When the effects of the various peptides on the strandtransfer step of the IN enzymatic reaction ... group of peptides is attributable to their effect on the turnover number of IN, and suggest a different mode of action from that of the rst group The third group of peptides, which included IN-4 and ... resembles that of INS [56] To convert some of these peptides into efcient antiHIV drugs, it is essential to elucidate their mode of action and their effects on the kinetic parameters of the 3Â-end...
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GRIMM’S FAIRY TALES-THE ADVENTURES OF CHANTICLEER AND PARTLET (PART 1)

GRIMM’S FAIRY TALES-THE ADVENTURES OF CHANTICLEER AND PARTLET (PART 1)

... pin and needle, who were fast asleep, and seizing them by the heads, stuck one into the landlord’s easy chair and the other into his handkerchief; and, having done this, they crept away as softly ... had laid by the way, and said they would give him the duck, who was in the habit of laying one every day: so at last he let them come in, and they bespoke a handsome supper, and spent the evening ... yard, heard them coming, and jumping into the brook which ran close by the inn, soon swam out of their reach An hour or two afterwards the landlord got up, and took his handkerchief to wipe his...
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Tài liệu Module 1: The Microsoft .NET Platform and XML pptx

Tài liệu Module 1: The Microsoft .NET Platform and XML pptx

... 12 Module 1: The Microsoft NET Platform and XML Lesson: XML as a W3C Standard ! Comparing XML and HTML ! W3C and the Process of Creating Standards ! W3C XML Technologies ! Applications and XML ... familiar with the various NET sites on http://www .microsoft. com and http://msdn .microsoft. com Module 1: The Microsoft NET Platform and XML Overview ! XML in the NET Platform ! XML as a W3C Standard ... developed and implemented ! Determine which XML processors are installed 2 Module 1: The Microsoft NET Platform and XML Lesson: XML in the NET Platform ! What Is the NET Platform? ! Standards...
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(1) how learners approach learning, both in and out of classrooms, and (2) the kinds of strategies and cognitive processing they use in second language acquisition

(1) how learners approach learning, both in and out of classrooms, and (2) the kinds of strategies and cognitive processing they use in second language acquisition

... learning problem Learners are generally aware of the strategies they use and can identify what they consist of if they are asked to pay attention to what they are doing/ thinking Strategies involve ... for the significance of language learning strategies in language teaching Firstly, by examining the strategies used by second language learners during the language learning process, educators and ... powerful impact of learning strategies on the learning and teaching of foreign and second language Good choice and use of learning strategies would help learners become more independent and autonomous...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx

Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx

... side-chains are important for the GABA transport activity 1- Deoxymannojirimycin inhibits the GABA- uptake of GAT1 In order to gain further insight into the role of the terminal structures of the N-glycans ... N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 to GABA Transport of GABA by GAT1 across the cell membrane ... trimming of their N-oligosaccharides strongly affected their GABAuptake activity These indicate that the terminal structure of the oligosaccharides facilitate efficient GABA- uptake activity of the...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf

Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf

... the arabinogalactans from potato, onion and soy was determined as described [21] Onion arabinogalactan consists of 99% D-galactose and 0.3% L -arabinose and is predominantly linear Potato arabinogalactan ... arabinogalactan consists of 86% D-galactose and 6.6% L -arabinose, while soy arabinogalactan consists of 57% D-galactose and 38% L -arabinose Methylation analysis demonstrated that a substantial amount ... transgalactooligosaccharides listed in Materials and methods Purification and characterization of GALA Hydrolysis of arabinogalactans To obtain an A niger transformant that produces increased levels of b-1,4-endogalactanase, ...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx

Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx

... FACS analysis of the internalization of the full-length Tat protein construct and the Tat CPP Differences in the mechanisms of internalization between the Tat peptide and the Tat fused protein ... at the surface of the Tat- containing recombinant proteins and call other reasons to explain the differences in the mechanism of internalization between the CPP peptide and the Tat- containing proteins ... alter the uptake of the Tat CPP These biochemical evidences con®rmed a pathway for the entry of the Tat peptide unrelated to the HS proteoglycan receptors Internalization of the Tat CPP did not...
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Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx

Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx

... attached to Thr3 enhances binding affinity of glycopeptides to the antibody [18] Conventional pepscan analysis however, does not allow easy analysis of the contribution of the carbohydrate portion To ... TSAPDTRPAPGST and the antibody SM3 was determined by Dokurno et al [19] They report a significant contribution of Arg4 to binding by analyzing the surface of the residues covered by the protein They also ... between ˚ the peptide and the non binding bottom of the Fab is 173 A2 which corresponds to about 36% of the interaction of the full peptide with the binding cavity of SM3 The sizes of the surfaces...
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Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt

Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt

... linked to, but distinct from, apoptosis [9,10] Beclin 1, a class III phosphatidylinositol 3-kinaseinteracting protein [11], plays a role in promoting autophagy [12] Beclin contains a Bcl-2- binding ... response to nutrient deprivation Autophagy is strongly upregulated in response to nutrient deprivation [19,29] To examine the autophagic response to starvation in HL-1 cells, GFP–LC3expressing cells ... Beclin control of the autophagic response to nutrient deprivation requires a functional Bcl-2 ⁄ -XL-binding domain We next investigated the control of Beclin and its binding partner, Bcl-2, on autophagic...
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Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf

Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf

... Allowing two substitutions Allowing two substitutions Allowing one substitution AAAGACATG AAAGACAGG AAAGAGATT AAAGAGATG AAAGACATA AAAGACATA AAAGAGAAC AAAGACATA AAAGAAAAG AAACAGATG AAAGAAAAG AAAGAAAAG ... EMSA Result Average Kd (nM) AAAGACATG AGAGACATG AAGGACATG AAATACATG AAAGCCATG AAAGAGATG AAAGACCTG AAAGACACG AAAGACATA + ND ND – – + ND ND ND + – – – – + – + – 0.25 1.5 p=0.01 60_HI 60M_HI Fig The ... namely AGAGACATG (P2), AAGGACATG (P3), AAATACATG (P4), AAAGCCATG (P5), AA AGAGATG (P6), AAAGACCTG (P7), AAAGACACG 3896 Cloning of the Hippi pDED domain and N-terminal domain of Hippi in the bacterial...
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Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc

Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc

... a-actinin, either in direct contact or in a complex including the two proteins In conclusion, our study proves the interaction between a-actinin and calpain and locates binding motifs within regions ... to the origin of interactions [9,10,12,27] with the targets, the stability of complexes in the resting stage [3,48] and the activation state [7,33] of the binding calpain The topology of the interface ... to interact with Calp1 This indicates the presence of a calpain binding site in the C-terminal domain of smooth muscle a-actinin Involvement of the C-terminal domain of ask in Calp1 binding In...
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Báo cáo khoa học: Plasmodium falciparum merozoite surface protein 1 Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte pdf

Báo cáo khoa học: Plasmodium falciparum merozoite surface protein 1 Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte pdf

... (fraction 11 ) The floating membranes from such a Triton X -10 0 extract of parasitized erythrocytes were enriched in the 19 -kDa C-terminal fragments of MSP -1 and in the erythrocytic, GPI-linked CD59 The ... (387– 413 and 11 00 11 87) within the sequences of blocks 5 16 of the two dimorphic forms The comparison could not be extended to the a-O-GlcNAc sites because the MSP -1 proteins of Thai-K1 and Wellcome ... solubilized proteins Fraction 11 is the gradient pellet containing whole parasites and remnants of the parasitophorous membranes (5 10 , 17 and 19 kDa), but only the [3H]GlcN-labelled 19 -kDa band is...
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