... Before treatment, hypofrontality was the most common (85%) finding, whereas after treatment hypofrontality was mostly cleared. However, in some areas like temporal and caudate, hyperfrontality was ... induced. Negative symptoms showed linkage to hypofrontality in both groups before and after treatment, and both positive and negative symptoms were improved more with Clozapine therapy than with classical ... order; general psychopathology, positive and negative symptoms. This finding shows the priority of positive symptom improvement to negative symptom by both treatments. Second, corresponding with...