... low-molecular-weight heparin and N-acetyl heparin promotean increase in FSAP activity rather than inhibitingit. Thus, polyanion binding to SERPINs, over and above their binding to FSAP, plays a decisive role in ... negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease Lars Muhl1, Sebastian P. Galuska1, Katariina Oăoărni2, Laura Hernandez-Ruiz3, Luminita-CorneliaAndrei-Selmer4, ... potential for binding to and activating FSAP.The heparin homologues N-acetyl heparin, de-N-sul-fated heparin and N-acetyl-de-O-sulfated heparin, which have the same size but reduced negative charge,neither...