... 20 × 25 × 400b 320 c 300b 29 0b 26 5 24 5 21 5 20 5 — 305 — 120 130 70 185 26 5 65 24 0 100 120 127 80 300 27 0 150 24 0 20 0 22 5 455 155 155 28 0 — 22 5 — 26 5 155 125 145 140 — 70 — 85 50 60 90 110 185 29 5 ... class of enzymes in humans is the dehydrogenase responsible for the metabolism of ethanol In contrast to the major 67 1 ,2 1 ,2 1 ,2 6,7 1A 2A 2B 2C 2F 1 1 ,2 2E 17,18,19 8,9,10 1 ,2 Human 1 ,2 Rabbit 2D ... coenzyme A as a cofactor and require the formation of a thioester with the carboxylic acid group, either of acetate or of the xenobiotic The thioester then reacts with an amine, either on the xenobiotic...