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CHAPTER 2 DRUGS BASE d ON a SUBSTI TUTED BENZENE RING

CHAPTER 2   DRUGS BASE d ON a SUBSTI TUTED BENZENE RING

CHAPTER 2 DRUGS BASE d ON a SUBSTI TUTED BENZENE RING

... to afford (36-5) Base catalyzed of that product with rhodanine (36-6) leads to aldol condensation to afford (36-7) Catalytic hydrogenation then reduces the double bond to afford the antidiabetic ... comparable pKAs Treatment with sodium azide and hydrochloric acid leads to 1,3 addition of the elements of hydrazoic acid 2. 3 ARYLSULFONIC ACID DERIVATIVES 65 to the nitrile and the formation ... secondary amine duloxetine (23 -5) [23 ] 60 DRUGS BASED ON A SUBSTITUTED BENZENE RING N-demethylation is a well-recognized drug metabolism transform that more often than not leads to the inactivation...
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báo cáo hóa học:

báo cáo hóa học: " Methyl salicylate 2-O-b-D-lactoside, a novel salicylic acid analogue, acts as an antiinflammatory agent on microglia and astrocytes" docx

... Iannitelli DAE, Cataldi A, Zara S, Nasuti C, Di Stefano A: Ibuprofen and Glutathione Conjugate as a Potential Therapeutic Agent for Treating Alzheimer’s Disease Arch Pharm (Weinheim) 2010 Ray B, Lahiri ... effect of ascorbic acid and acetylsalicylic acid on prostaglandin E2 release in primary rat microglia J Neurochem 2003, 86:173-178 14 Candelario-Jalil E, de Oliveira AC, Graf S, Bhatia HS, Hull ... the data and wrote the manuscript; XL performed cell culture, western blot analysis, ELISA assay and NO measurements; RL and LS helped in performing NO measurements All authors read and approved...
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H.D ÔN THI TN TOÁN 12 (2)

H.D ÔN THI TN TOÁN 12 (2)

... Ph.trình tiếp tuyến y= 12( x+2) – =12x + 16  f '(x ) = 12  c/ Ta có tung độä y = –8 ⇔ f(x )= -8 ⇔ x =-8 ⇒ x =-2 ⇒ f’(x ) =12 ⇒ Phương trình tiếp tuyến là: y= 12( x+2) – = 12x + 16 b/ Ta có x0= -2 ⇒ 0 ... biến thi n -∞ x y/ y +∞ -1 + +∞ + -∞ Điểm đặc biệt: A(0;-2), B(1; 0), C(-2;6), D(-3;4) y Đồ thò: -8 -6 -4 -2 -2 x -4 -6 -8 Chủ đề II: MỘT SỐ BÀI TOÁN LIÊN QUAN TỚI KHẢO SÁT HÀM SỐ I/ Bài toán ... ơn tập Tốn 12 x + 2.71− x − = i) (TN – 2007) j) Dạng Logarit hóạ Bài Giải phương trình a) 2x - = d) x−2 = 5x b) 3x + = 5x – 2 −5 x + 22 x + − 9.2 x + = c) 3x – = e) x.8 x −1 x 5x − x +12 f) 52x...
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Chapter 2: Pressure Distribution in a Fluid

Chapter 2: Pressure Distribution in a Fluid

... B x B Ans 2.5 Atlanta, Georgia, has an average altitude of 1100 ft On a U.S standard day, pressure gage A reads 93 kPa and gage B reads 105 kPa Express these readings in gage or vacuum pressure, ... pressure in the air space: pair 10500 Pa Ans Chapter Pressure Distribution in a Fluid 65 2.11 In Fig P2.11, sensor A reads 1.5 kPa (gage) All fluids are at 20C Determine the elevations Z in ... is appropriate Chapter Pressure Distribution in a Fluid 63 Solution: We can find atmospheric pressure by either interpolating in Appendix Table A. 6 or, more accurately, evaluate Eq (2.27) at...
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Tài liệu Chapter 2: Motion Along a Straight Line docx

Tài liệu Chapter 2: Motion Along a Straight Line docx

... vertical axis at x = xo v = v0 + at The v(t) versus t plot is a straight line with Slope = a and Intercept = vo The acceleration a is a constant (2-9) Free Fall Close to the surface of the earth all ... displacement Δx as in the case of vavg) savg total distance = ∆t Note: The average velocity and the average speed for the same time interval Δt can be quite different Instantaneous Velocity The average ... described by the algebraic sign of Δx Note: The actual distance for a trip is irrelevant as far as the displacement is concerned Consider as an example the motion of an object from an initial position...
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Tài liệu Activity 7.2: Determining the Impact of Technology on a Windows DNA Design docx

Tài liệu Activity 7.2: Determining the Impact of Technology on a Windows DNA Design docx

... Activity 7.2: Determining the Impact of Technology on a Windows DNA Design Exercise 1: Determining Technology Implications ! Determine technology implications Participate in small groups as assigned ... Determining the Impact of Technology on a Windows DNA Design 51 Write your answers in the table below User Interface User Services Business Services Data Access Data Store Communication Operating Systems ... by the instructor Identify the level of impact — high, medium, or low — that each technology type would have on the given layer of a Windows DNA design Write your answers in the grid provided After...
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iec 60332-2 tests on electric cables under fire conditions - test on a single small vertical insu

iec 60332-2 tests on electric cables under fire conditions - test on a single small vertical insu

... 332: - Tests on electric cables under fire conditions Part 1: Test on a single vertical insulated wire or 33 2-1 (1979) cable Part 2: Test on a single small vertical insulated copper 33 2-2 (1989) ... Part 1: Tests Part 2: General and construction requirements Tests on oil-filled and gas-pressure cables and their accessories 14 1-1 (1976) Part : Oil-filled, paper-insulated, metal-sheathed cables ... 4A4 4A7 L 0029047 O - - INTERNATIONAL ELECTROTECHN I C A L COMMISSION TESTS ON ELECTRIC CABLES UNDER FIRE CONDITIONS P a r t 2: T e s t on a single small vertical insulated copper w i r e or cable...
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Tài liệu Using Samba-2. Installing Samba on a Unix System-P1 pptx

Tài liệu Using Samba-2. Installing Samba on a Unix System-P1 pptx

... Binary or Source? Precompiled packages are also available for a large number of Unix platforms These packages contain binaries for each of the Samba executables as well as the standard Samba documentation ... Installation Directories Directory Description /usr/local /samba Main tree /usr/local /samba/ bin Binaries /usr/local /samba/ lib smb.conf, lmhosts, configuration files, etc /usr/local /samba/ man Samba documentation ... Configure a makefile Compile the server code Install the server files Create a Samba configuration file Test the configuration file Start the Samba daemons Test the Samba daemons 2.1 Downloading...
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Tài liệu Using Samba-2. Installing Samba on a Unix System-P2 pdf

Tài liệu Using Samba-2. Installing Samba on a Unix System-P2 pdf

... /usr/local /samba swat stream tcp nowait.400 /usr/local /samba/ bin/swat root swat And that's pretty much it for the installation Before you can start up Samba, however, you need to create a configuration ... installed all the files Congratulations! You now have Samba on your system! 2.3.1 Final Installation Steps There are a couple of final steps to perform Specifically, add the Samba Web Administration ... correctly There are three ways to start: • By hand • As stand-alone daemons • From inetd 2.5.1 Starting the Daemons by Hand If you're in a hurry, you can start the Samba daemons by hand As root, simply...
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Tài liệu Lab 6.2.8 Password Recovery Procedure on a Catalyst 2900 Series Switches ppt

Tài liệu Lab 6.2.8 Password Recovery Procedure on a Catalyst 2900 Series Switches ppt

... host and switch configurations Step Reset the console password a Have a classmate change the console and VTY passwords on the switch Save the changes to the startup-config file and reload the ... labs in CCNA and CCNA it is necessary to start with an unconfigured switch Use of a switch with an existing configuration may produce unpredictable results These instructions allow preparation ... now reloaded Change the old unknown passwords as follows: ALSwitch#configure terminal ALSwitch(config)#no enable secret ALSwitch(config)#enable password Cisco ALSwitch(config)#line console ALSwitch(config-line)#password...
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Tài liệu Lab 6.2.8 Password Recovery Procedure on a Catalyst 2900 Series Switches docx

Tài liệu Lab 6.2.8 Password Recovery Procedure on a Catalyst 2900 Series Switches docx

... switch configurations Step Reset the console password a Have a classmate change the console and VTY passwords on the switch Save the changes to the startup-config file and reload the switch b ... section, and contact the Cisco Technical Assistance Center (TAC) for password recovery Note: This section is also applicable for those Catalyst 2800 switches that not have the Mode button in ... configuration file is now reloaded Change the old unknown passwords as follows: ALSwitch#configure terminal ALSwitch(config)#no enable secret ALSwitch(config)#enable password Cisco ALSwitch(config)#line...
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Tài liệu C++ Lab 2 Sending the output to a printfile Data Types: Chapter 2 ppt

Tài liệu C++ Lab 2 Sending the output to a printfile Data Types: Chapter 2 ppt

... problem What are the known information about this programming assignemnt? There are ten dollars in a quarter roll There are five dollars in a dime roll There are two dollars in a nickel roll And there ... indicates the beginning of the main int dollar, quarterR, dimeR, nickelR, pennyR, remainder; Variables that are used in the main are declared There are six variables of type integer These variable names ... change -> "; Displays the prompt to the user cin >> dollar; Waits for the user to type in a value at the keyboard When a value is entered, that value is stored in the memory location referred to...
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Báo cáo khoa học:

Báo cáo khoa học: "PDT 2.0 Requirements on a Query Language" pptx

... often are) represented by one node on the tectogrammatical layer and new nodes without an analytical counterpart may appear on the tectogrammatical layer It is necessary that the query language addresses ... than on the tectogrammatical layer Nevertheless, they appear also on the tectogrammatical layer and their contribution to the requirements on the query language has already been mentioned The only ... accessing lower layers with non-1:1 relation Afterwards, we add some requirements on a query language set by the annotation of the lower layers – the analytical layer and the morphological layer During...
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