... Review Rasburicase represents a new tool for hyperuricemia in tumor lysis syn-drome and in gout Lisa Cammalleri and Mariano Malaguarnera Dept of Senescence, Urological and Neurological Sciences, ... monophosphate (GMP), the purinic nucleotides useful for DNA and RNA synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid. Hypoxanthine and guanine ... it may cause. A rapid and massive raise of uric acid, during tumor lysis syn-drome (TLS), and also a lower and chronic hyperuricemia, as in gout, mainly damage the kidney. To prevent or treat...