... MCF-10 mammary epithelial cells, weanalyzed the effect of DPA, EPA, and DHA on acti-vation of Jak2 and Stat5. Whereas DPA and EPAactivated Jak2 and Stat5, DHA did not induce Jak2 and Stat5 phosphorylation ... PUFA and partic-ularly an n-3 DPA and EPA. An increase in n-3 DPA and EPA, and perhaps other n-3 PUFAs, stimulatesJak2 and Stat5 activation, and induces b-casein expres-sion and gland differentiation. ... transgenicmouse, fat-1 can convert n-6 to n-3 fatty acids and Table 1. Analyses of fatty acid ratio and relative contents of n-3 PUFAs EPA, DPA, and DHA in mammary glands. Whole inguinal mammary fat...